DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nhe2 and Slc9a1

DIOPT Version :9

Sequence 1:	NP_001137851.1	Gene:	Nhe2 / 35376	FlyBaseID:	FBgn0040297	Length:	1322	Species:	Drosophila melanogaster
Sequence 2:	NP_058677.1	Gene:	Slc9a1 / 20544	MGIID:	102462	Length:	820	Species:	Mus musculus

Alignment Length:	706	Identity:	306/706 - (43%)
Similarity:	443/706 - (62%)	Gaps:	70/706 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 WRGMFSKRTLLICALALILGSAQARPNTSAVGVAPRKVSQDIVDAVTQLNLGQSAPIDAVDVG-L 151
            |.|::......|....|::        .:.||:.|...|..:..:.|...:..|.|.....:| :
Mouse     5 WSGVWGFHPPRIFPSLLVV--------VALVGLLPVLRSHGLQHSPTASTIRGSEPPRERSIGDV 61

  Fly   152 DPTPSARVPRPEPLKSGDENAKG---DEGHKMER--YPLSSVDFARVKTPFIIGIWILSASIAKI 211
            ...||..:.||:     |.|...   :.|.|..|  :|:..:|:..|:|||.|.:|||.|.:.||
Mouse    62 TTAPSEPLHRPD-----DHNLTNLIIEHGGKPSRKAFPVLDIDYPHVRTPFEISLWILLACLMKI 121

  Fly   212 GFHMTPKLHLIFPESCLLIVVGVVIGVVLYFCTDVAVSP--LTPNTFFFYMLPPIILDAGYFMPN 274
            |||:.|.:..|.||||||||||:::|.::   ..|..:|  |..:.||.::|||||||||||:|.
Mouse   122 GFHVIPTISSIVPESCLLIVVGLLVGGLI---KGVGETPPFLQSDVFFLFLLPPIILDAGYFLPL 183

  Fly   275 RLFFDNLGTILLMAVVGTIFNIATIGGSLYACGKMGIYGES-ETPGLMDVFLFASLISAVDPVAV 338
            |.|.:||||||:.|||||::|...:||.|||...:|  ||. ...||:|..||.|:|||||||||
Mouse   184 RQFTENLGTILIFAVVGTLWNAFFLGGLLYAVCLVG--GEQINNIGLLDTLLFGSIISAVDPVAV 246

  Fly   339 LAVFEEIHVNEILYIVVFGESLLNDAVTVVMYHMME---SYNEIGLDKIIAQDIASGVGSFFVVA 400
            ||||||||:||:|:|:||||||||||||||:||:.|   ||:.:|:     .||..|..||||||
Mouse   247 LAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFASYDSVGI-----SDIFLGFLSFFVVA 306

  Fly   401 LGGTAIGIIWGFLTGLVTRFTDHVRVIEPIFIFVMAYLAYLNAEIFHMSGILAITFCGITMKNYV 465
            |||..:|:::|.:....:|||.|:|||||:|:|:.:|:|||:||:||:|||:|:...|:.|:.||
Mouse   307 LGGVFVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYV 371

  Fly   466 ESNISQKSHTTVKYALKMLSSSAETIIFMFLGVATVNNMHVWNTWFVVLTIAFCSVFRVIGVILL 530
            |:|||.|||||:||.|||.||.:||:||:||||:||...|.||..||:.|:.||.:.||:||::|
Mouse   372 EANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHQWNWTFVISTLLFCLIARVLGVLVL 436

  Fly   531 SALANRFRLHKLSRVDQFVMSYGGLRGAVAFALVLLVDENVVKQKNMFVTTTIAVIYFTVFLQGI 595
            :...|:||:.||:..|||:::|||||||:||:|..|:|:......::|:|..|.||:||||:||:
Mouse   437 TWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDKKHFPMCDLFLTAIITVIFFTVFVQGM 501

  Fly   596 TIKPLVKILNVKRANKRKPTMNERIHERFMDHLMAGIEDIVGKTGNYNVRDKFKRFDNRFIRPLL 660
            ||:|||.:|.||:..:.|.::||.||.:|:|||:.|||||.|..|:::.:||..||:.::::..|
Mouse   502 TIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFNKKYVKKCL 566

  Fly   661 IRDLKGAEPKIIETYSKLTMRDAMEV-----MRRNPSTIGQMTGTESMSALF-RNYTNNYIGGSP 719
            |...:..||::|..|.|:.|:.|:|:     |.:.||.:    .|.||..:. :..|::.|  .|
Mouse   567 IAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSAV----STVSMQNIHPKAVTSDRI--LP 625

  Fly   720 SLTNLDNTCSRNLDMAELDYNPSKKDLTDARIHHLLAEELKPYRRHRRLSYSRHAV 775
            :|:                     || .:..|..:|...|:..|:..| ||:||.:
Mouse   626 ALS---------------------KD-KEEEIRKILRSNLQKTRQRLR-SYNRHTL 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nhe2	NP_001137851.1	b_cpa1	189..704	CDD:273294	268/525 (51%)
Nhe2	NP_001137851.1	Na_H_Exchanger	199..602	CDD:279355	224/408 (55%)
Slc9a1	NP_058677.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..74		8/38 (21%)
		b_cpa1	99..664	CDD:273294	284/599 (47%)
		Na_H_Exchanger	109..507	CDD:279355	223/407 (55%)
		Interaction with TESC. /evidence=ECO:0000250\|UniProtKB:P19634	507..549		20/41 (49%)
		Interaction with CHP2. /evidence=ECO:0000250\|UniProtKB:P19634	519..549		16/29 (55%)
		NEXCaM_BD	606..704	CDD:293250	18/78 (23%)
		Interaction with CALM1. /evidence=ECO:0000250\|UniProtKB:P19634	637..820		8/23 (35%)
		Interaction with TESC. /evidence=ECO:0000250\|UniProtKB:P19634	637..820		8/23 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	748..820
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848709
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000129
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101278
Panther	1	1.100	-	-	O	PTHR10110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.740