DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nhe2 and Slc9a5

DIOPT Version :9

Sequence 1:NP_001137851.1 Gene:Nhe2 / 35376 FlyBaseID:FBgn0040297 Length:1322 Species:Drosophila melanogaster
Sequence 2:NP_620213.1 Gene:Slc9a5 / 192215 RGDID:620473 Length:898 Species:Rattus norvegicus


Alignment Length:1065 Identity:366/1065 - (34%)
Similarity:519/1065 - (48%) Gaps:231/1065 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   143 PIDAVDVGLDPTPSARVPRPEPLKSGDENAKGDEGHKMERYPLSSVDFARVKTPFIIGIWILSAS 207
            |:..|....:||     ..|.||  |:     ..|..:.|:     .:..|:.|:::.:|||.||
  Rat    13 PLAGVGATEEPT-----QEPGPL--GE-----PPGLALFRW-----QWHEVEAPYLVALWILVAS 60

  Fly   208 IAKIGFHMTPKLHLIFPESCLLIVVGVVIGVVLYFCTDVAVSPLTPNTFFFYMLPPIILDAGYFM 272
            :|||.||::.|:..:.|||||||::|:.:|.::......|...|.|.|||.::||||:||:||||
  Rat    61 LAKIVFHLSRKVTSLVPESCLLILLGLALGGIVLAVAKKAEYQLEPGTFFLFLLPPIVLDSGYFM 125

  Fly   273 PNRLFFDNLGTILLMAVVGTIFNIATIGGSLYACGKMGIYGESETPGLMDVFLFASLISAVDPVA 337
            |:||||||||.||..|||||::|..|.|.:|:...:.|:.......||:|..||.||||||||||
  Rat   126 PSRLFFDNLGAILTYAVVGTLWNAFTTGVALWGLQQAGLVAPRVQAGLLDFLLFGSLISAVDPVA 190

  Fly   338 VLAVFEEIHVNEILYIVVFGESLLNDAVTVVMYHMMESYNEIGLDKIIAQDIASGVGSFFVVALG 402
            |||||||:||||.|:|:||||||||||||.|:|.:..|:.|:|...:.|.|...||.|.|||:||
  Rat   191 VLAVFEEVHVNETLFIIVFGESLLNDAVTAVLYKVCNSFVEMGSANVQATDYLKGVASLFVVSLG 255

  Fly   403 GTAIGIIWGFLTGLVTRFTDHVRVIEPIFIFVMAYLAYLNAEIFHMSGILAITFCGITMKNYVES 467
            |.|:|:::.||..|.||||..||:|||:.:|::||.|||.||:..:|.|||:|.||:..|.|||:
  Rat   256 GAAVGLVFAFLLALTTRFTKRVRIIEPLLVFLLAYAAYLTAEMASLSAILAVTMCGLGCKKYVEA 320

  Fly   468 NISQKSHTTVKYALKMLSSSAETIIFMFLGVATVNNMH-VWNTWFVVLTIAFCSVFRVIGVILLS 531
            |||.||.|.|||.:|.|:|||||:|||.||::.|::.. .|::..|:.|:.|...||.:||:|.:
  Rat   321 NISHKSRTAVKYTMKTLASSAETVIFMLLGISAVDSSKWAWDSGLVLGTLFFILFFRALGVVLQT 385

  Fly   532 ALANRFRLHKLSRVDQFVMSYGGLRGAVAFALVLLVDENVVKQKNMFVTTTIAVIYFTVFLQGIT 596
            .:.|:|||..|.::||.||||||||||||||||:|:|...|..|:.||.|||.|::|||.:||:|
  Rat   386 WVLNQFRLAPLDKIDQVVMSYGGLRGAVAFALVILLDRTKVPAKDYFVATTIVVVFFTVIVQGLT 450

  Fly   597 IKPLVKILNVKRANKRKPTMNERIHERFMDHLMAGIEDIVGKTGNYNVRDKFKRFDNRFIRPLLI 661
            ||||||.|.|||::..|||:|:.:||...||::|.:||:||..|.:..||::::||.:::..||:
  Rat   451 IKPLVKWLRVKRSDYHKPTLNQELHEHTFDHILAAVEDVVGHHGYHYWRDRWEQFDKKYLSQLLM 515

  Fly   662 RDLKGA---EPKIIETYSKLTMRDAMEVMRRNPSTIGQMTGTESMSALFRNYTNNYIGGSPSLTN 723
            |  :.|   ..:|.:.|.:|.:|||:..:.:....:.. .|....|...||..     ...|:||
  Rat   516 R--RSAYRIRDQIWDVYYRLNIRDAISFVDQGGHVLSS-AGLTLPSMPSRNSV-----AETSVTN 572

  Fly   724 L-----DNTCSRNLDMAELDYNPSKKDLTDARIHHLLAEELKPYRRHRRLSYSRHAVDDRDLSTQ 783
            |     ...|   ||:..:|...|.:|..||.:||||...|...||..:.|.|||.:.:.....|
  Rat   573 LLRESGSGAC---LDLQVIDTVRSGRDREDAVMHHLLCGGLYKPRRRYKASCSRHFISEDAQERQ 634

  Fly   784 VNYKMQMNFRR---MFNDRKH---------------HKRSKRGASNKEAKENVKQNHVSFHDFQQ 830
            .....|.|.:|   .|...||               ||: |.|.:|.||........:.|.|...
  Rat   635 DKEVFQQNMKRRLESFKSTKHNICFTKSKPRPRKTGHKK-KDGVANPEATNGKPPRDLGFQDTAA 698

  Fly   831 NGTTKQLTNGTESSSNHSRKKSYRKRHTHNSLNKYRRLEIAEECQQNPNEINVVGPSDDWDDGLT 895
            ...|.:.....||.|:.:.|:.                                      |:|:.
  Rat   699 VILTVESEEEEESESSETEKED--------------------------------------DEGII 725

  Fly   896 FTAKSSPDSDRANNNSLIAHIQNLPGFDASKARIVVQHYAPKADDNPDTDIESPEQAIGPTAAEL 960
            |.|:::  |:......:...::..|                           ||.          
  Rat   726 FVARAT--SEVLQEGKVSGSLEVCP---------------------------SPR---------- 751

  Fly   961 ILPWRRDRSYQSIVAEHPIPEEDRNLSRESDGERRVATPTATESQLPWKR-QGD-------ECTD 1017
            |:|                                 .:||..|.:||||. |||       |.|.
  Rat   752 IIP---------------------------------PSPTCAEKELPWKSGQGDLAVYVSSETTK 783

  Fly  1018 AVQQNEFPAW---ASNKEYLAYNSPSATFLGGINK-------PKQPKSVIGLFRRESSSSKAGSV 1072
            .|..:....|   .|:.|.||  ||..|....:.:       |::|:                  
  Rat   784 IVPVDMQTGWNQSISSLESLA--SPPCTQPPTLTRLPPHPLVPEEPQ------------------ 828

  Fly  1073 GVGSTGAMDSAASGSETMVVSMSSQPPNAPSTSIHNPRLDKRSQSISSSSLGAGAHQ-----LGP 1132
                             :.:.:||.|   .|:....|.|.|..:|.|.||......|     :|.
  Rat   829 -----------------VPLDLSSDP---RSSFAFPPSLAKAGRSRSESSADIPQQQELQPLMGH 873

  Fly  1133 EGHS--GPFPVTASHRRNVRRGSML 1155
            :.|:  .|.|..:.......||..|
  Rat   874 KDHTHLSPGPANSHWCIQFNRGGRL 898

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nhe2NP_001137851.1 b_cpa1 189..704 CDD:273294 257/518 (50%)
Na_H_Exchanger 199..602 CDD:279355 220/403 (55%)
Slc9a5NP_620213.1 b_cpa1 43..632 CDD:273294 283/599 (47%)
Na_H_Exchanger 52..457 CDD:279355 221/404 (55%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 660..692 7/32 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 801..888 24/126 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166352298
Domainoid 1 1.000 487 1.000 Domainoid score I371
eggNOG 1 0.900 - - E1_COG0025
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H31247
Inparanoid 1 1.050 579 1.000 Inparanoid score I993
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000129
OrthoInspector 1 1.000 - - otm45826
orthoMCL 1 0.900 - - OOG6_101278
Panther 1 1.100 - - O PTHR10110
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X654
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1312.790

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