Protein Alignment Nhe2 and nhx-1

DIOPT Version :10

• Sequence 1: NP_001137851.1
• Gene: Nhe2 / 35376
• FlyBaseID: FBgn0040297
• Length: 1322
• Species: Drosophila melanogaster
• Sequence 2: NP_510622.3
• Gene: nhx-1 / 181680
• WormBaseID: WBGene00003729
• Length: 514
• Species: Caenorhabditis elegans
• Alignment Length: 510
• Identity: 213/510 - (41%)
• Similarity: 320/510 - (62%)
• Gaps: 5/510 - (0%)

  Fly   185 LSSVDFARVKTPFIIGIWILSASIAKIGFHMTPKLHLIFPESCLLIVVGVVIGVVLYFCTDVAVS 249
            |:.:.:.|.:||.::|:|:|....||||||..|:....||||.:|||:|:..|..:|....|.:.
 Worm     4 LAVMQWNRPETPTLLGLWLLLIVGAKIGFHRMPRARHFFPESAVLIVLGLFAGFTIYELWTVDLF 68

  Fly   250 PLTPNTFFFYMLPPIILDAGYFMPNRLFFDNLGTILLMAVVGTIFNIATIGGSLYACGKMGIYGE 314
             |.|:.||.|:||||:|:|||||||:.|..|:.||.|.||.||:.||......::|.  ...|..
 Worm    69 -LHPDLFFLYLLPPIVLEAGYFMPNKAFISNITTISLFAVAGTVMNIFLTSCFIFAF--QNFYDF 130

  Fly   315 SETPGLMDVFLFASLISAVDPVAVLAVFEEIHVNEILYIVVFGESLLNDAVTVVMYHMMESYNEI 379
            :.|  ::|..||:::||||||||||:||||||||::|||.||||||||||||||:||...|...|
 Worm   131 NIT--IVDTLLFSTVISAVDPVAVLSVFEEIHVNKLLYITVFGESLLNDAVTVVLYHSFHSMVRI 193

  Fly   380 GLDKIIAQDIASGVGSFFVVALGGTAIGIIWGFLTGLVTRFTDHVRVIEPIFIFVMAYLAYLNAE 444
            |...:|.||....:.:||:|:.||..:|:::..:..|..:::.:|.|::||....:.|:|||.:|
 Worm   194 GQAHLIYQDYTMSMMNFFLVSGGGILVGVVFAVVAALGVKWSSNVSVLQPIICITVPYMAYLCSE 258

  Fly   445 IFHMSGILAITFCGITMKNYVESNISQKSHTTVKYALKMLSSSAETIIFMFLGVATVNNMHVWNT 509
            |.|:||||.|..||:.||:||..::.:::..||||.||.|||..|.|||:|||.:..:..|.|:.
 Worm   259 IVHVSGILGIVVCGLCMKSYVTGSMEERADITVKYTLKTLSSCCEAIIFVFLGFSIFSKDHKWDF 323

  Fly   510 WFVVLTIAFCSVFRVIGVILLSALANRFRLHKLSRVDQFVMSYGGLRGAVAFALVLLVDENVVKQ 574
            .|.::|:..|...|.:.|..|:.:||::|:.|:|..||.:|::||||||:.|.|||.:|..||..
 Worm   324 GFAIVTVITCFAARFLVVFTLTWVANKWRMQKISLRDQTIMAFGGLRGAICFGLVLTIDGEVVPA 388

  Fly   575 KNMFVTTTIAVIYFTVFLQGITIKPLVKILNVKRANKRKPTMNERIHERFMDHLMAGIEDIVGKT 639
            |.:.::||:.||.||||:||..|||||..||||..|....::.:...|...:..|.|:|.|:|..
 Worm   389 KPIMISTTLIVIVFTVFIQGTMIKPLVSFLNVKIDNAYDKSLFQSCIEHSFEDTMCGVEAIIGAH 453

  Fly   640 GNYNVRDKFKRFDNRFIRPLLIRDLKGAEPKIIETYSKLTMRDAMEVMRRNPSTI 694
            |.|..::|..:::.:|:.|.|.|.......::::..:.:|..:..|.:.:..|.:
 Worm   454 GQYYWKNKVDKWNAQFLEPALTRQDMNRGRRLLKKLTDMTTDEQREALLQEESAM 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe2	NP_001137851.1	Na_H_Exchanger	189..704	CDD:470090	212/506 (42%)
nhx-1	NP_510622.3	Na_H_Exchanger	28..486	CDD:470090	203/462 (44%)