Protein Alignment Nhe2 and nhx-9

DIOPT Version :9

• Sequence 1: NP_001137851.1
• Gene: Nhe2 / 35376
• FlyBaseID: FBgn0040297
• Length: 1322
• Species: Drosophila melanogaster
• Sequence 2: NP_001023628.1
• Gene: nhx-9 / 178126
• WormBaseID: WBGene00003736
• Length: 667
• Species: Caenorhabditis elegans
• Alignment Length: 689
• Identity: 257/689 - (37%)
• Similarity: 411/689 - (59%)
• Gaps: 82/689 - (11%)

  Fly   197 FIIGIWILSASIAKIGFHMTPKLHLIFPESCLLIVVGVVIGVVLYFCTDVAVSPLTPNTFFFYML 261
            ::|.:|:|.||:|||.|::...:....|:|.|||:||:.:|.:|: .|.::.:.|..:|||.|:|
 Worm    42 YVITVWLLIASLAKILFNLMKPISKWCPDSSLLIIVGLALGWILH-QTSLSGATLDSHTFFLYLL 105

  Fly   262 PPIILDAGYFMPNRLFFDNLGTILLMAVVGTIFNIATIGGSLYACGKMGIYGESETPGLMDVFLF 326
            ||||.|||||||||..|:|..::|:.:|.|||:|...|||||....:..::..|.|  ..::.:|
 Worm   106 PPIIFDAGYFMPNRALFENFDSVLVFSVFGTIWNTFAIGGSLLLMAQYDLFTMSFT--TFEILVF 168

  Fly   327 ASLISAVDPVAVLAVFEEIHVNEILYIVVFGESLLNDAVTVVMYHMMESYNEIGLDKIIAQDIAS 391
            ::||||||||||:||||||||||.|:|.||||:|.||.||||:|.|.:|:..||.:.:...|.|:
 Worm   169 SALISAVDPVAVIAVFEEIHVNEFLFINVFGEALFNDGVTVVLYQMFKSFALIGSENLSVLDYAT 233

  Fly   392 GVGSFFVVALGGTAIGIIWGFLTGLVTRFTDHVRVIEPIFIFVMAYLAYLNAEIFHMSGILAITF 456
            |..|||||||||.|:|||:.....|.|::|..||::.|:||||:.|:|||.||:..:|.|:||..
 Worm   234 GGLSFFVVALGGAAVGIIFAIAASLTTKYTYDVRILAPVFIFVLPYMAYLTAEMVSLSSIIAIAI 298

  Fly   457 CGITMKNYVESNISQKSHTTVKYALKMLSSSAETIIFMFLGVATVNNMHVWNTWFVVLTIAFCSV 521
            ||:.||.|::.|::|.:..:|||..|||:.|:||:||||||::|:::.|.::.:|:..|:.||.:
 Worm   299 CGMLMKQYIKGNVTQAAANSVKYFTKMLAQSSETVIFMFLGLSTISSQHHFDLYFICATLFFCLI 363

  Fly   522 FRVIGVILLSALANRFRLHKLSRVDQFVMSYGGLRGAVAFALVLLVDENVVKQKNMFVTTTIAVI 586
            :|.||:::...:.||||..|...||||:|||||||||:|:.||:.:..::. .|.||:|.|||||
 Worm   364 YRAIGIVVQCYILNRFRAKKFEMVDQFIMSYGGLRGAIAYGLVVSIPASIT-AKPMFITATIAVI 427

  Fly   587 YFTVFLQGITIKPLVKILNVKRANKRKPTMNERIHERFMDHLMAGIEDIVGKTGNYNVRDKFKRF 651
            |||||||||||:|||..|.:|:..:|.|||.|.::.:::|::|:|:|||.|:.|:|...:.|:||
 Worm   428 YFTVFLQGITIRPLVNFLKIKKKEERDPTMVESVYNKYLDYMMSGVEDIAGQKGHYTFIENFERF 492

  Fly   652 DNRFIRPLLIRDLKGAE---PKIIETYSKLTMRDAMEVMRRNPSTIGQMTGTESMSALFRNYTNN 713
            :.:.|:|:|:|..|...   ..|:..|.|:|:.||:::.:
 Worm   493 NAKVIKPVLMRHQKRESFDASSIVRAYEKITLEDAIKLAK------------------------- 532

  Fly   714 YIGGSPSLTNLDNTCSRNLDMAELDYNPSKKDLTDARIHHLLAEELKPYRRHRRLSYSRHAVDDR 778
                          ...|:....|:...||     .|:..:|.:::.          ::..:..:
 Worm   533 --------------VKNNIQNKRLERIKSK-----GRVAPILPDKIS----------NQKTMTPK 568

  Fly   779 DLSTQVNYKMQMNFRRMFN------DRKHHKRSKRGA--SNKEAKENVKQNHVSFHDFQQN---- 831
            ||..:...:...|...::.      |||.|:.::...  ::.:.:::::.::::....:.|
 Worm   569 DLQLKRFMESGENIDSLYTLFSDLLDRKLHEMNRPSVQITDVDGQDDIQDDYMAEVGSRSNLSAM 633

  Fly   832 -GTTKQLTNGTESSSNHSRKKSYRKRHTHNSLNKYRRLE 869
             .:|:||.:.|...|.        :|.:...||..||.:
 Worm   634 FRSTEQLPSETPFHSG--------RRQSTGDLNATRRAD 664

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe2	NP_001137851.1	b_cpa1	189..704	CDD:273294	233/509 (46%)
		Na_H_Exchanger	199..602	CDD:279355	202/402 (50%)
nhx-9	NP_001023628.1	Na_H_Exchanger	44..443	CDD:279355	202/402 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	406	1.000	Domainoid score	I358
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2218
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000129
OrthoInspector	1	1.000	-	-		otm14083
orthoMCL	1	0.900	-	-		OOG6_101278
Panther	1	1.100	-	-	O	PTHR10110
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2680
SonicParanoid	1	1.000	-	-		X654
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.890