Protein Alignment Nhe2 and nhx-2

DIOPT Version :9

• Sequence 1: NP_001137851.1
• Gene: Nhe2 / 35376
• FlyBaseID: FBgn0040297
• Length: 1322
• Species: Drosophila melanogaster
• Sequence 2: NP_495614.4
• Gene: nhx-2 / 174242
• WormBaseID: WBGene00003730
• Length: 644
• Species: Caenorhabditis elegans
• Alignment Length: 617
• Identity: 252/617 - (40%)
• Similarity: 386/617 - (62%)
• Gaps: 31/617 - (5%)

  Fly   175 DEGHKMERYPLSSVDFARVKTPFIIGIWILSASIAKIGFHMTPKLHLIFPESCLLIVVGVVIGVV 239
            :|.....|||::..::..||.|..|.:|::.||||||.|::.|.|:.:||:|.|||::|::||::
 Worm    28 EEKEYPSRYPIAYFEWENVKIPMTICLWLIGASIAKIIFNLIPHLNELFPDSALLIMIGLIIGII 92

  Fly   240 LYFCTDVAVSP----LTPNTFFFYMLPPIILDAGYFMPNRLFFDNLGTILLMAVVGTIFNIATIG 300
            ...   :.|:.    |....|..|:|||::.|||||||.|.||||.|:||..|::||.|||..|.
 Worm    93 FKL---IGVNKNAFFLESEVFMLYLLPPLVFDAGYFMPARQFFDNFGSILCFAMIGTSFNIVAIA 154

  Fly   301 GSLYACGKMGIYGESETPGLMDVFLFASLISAVDPVAVLAVFEEIHVNEILYIVVFGESLLNDAV 365
            .||:|....|:: ..||| ||.:.||.|:.:.||||||:.:|||:.|||:|:|.|||||||||.|
 Worm   155 LSLWAISLTGLF-SVETP-LMHMLLFGSVAADVDPVAVIVIFEELKVNEVLFIAVFGESLLNDGV 217

  Fly   366 TVVMYHMMESYNEIGLDKIIAQDIASGVGSFFVVALGGTAIGIIWGFLTGLVTRFT--DHVRVIE 428
            .||:|.|..:::|||.:.:|..|..:|..||.|||.||..||:::.|||.|||||.  :.|:|:.
 Worm   218 AVVLYRMFLTFSEIGTENLITSDYINGGVSFLVVAFGGIGIGLLFAFLTSLVTRFARDEEVKVLN 282

  Fly   429 PIFIFVMAYLAYLNAEIFHMSGILAITFCGITMKNYVESNISQKSHTTVKYALKMLSSSAETIIF 493
            .:||.::.|..||..|:|.:|.|:||.|||..|:.|...|:...:....:..:|:||.::||:||
 Worm   283 SVFILILPYTCYLCGELFGLSSIMAIVFCGAAMRQYCRENVDPDTVKATESFIKVLSLASETVIF 347

  Fly   494 MFLGVATVNNMHVWNTWFVVLTIAFCSVFRVIGVILLSALANRFRLHKLSRVDQFVMSYGGLRGA 558
            :|||::||::.|.|:|.|:|||:.||.::|.:||:::....|::||:|.::||||:|:|||||||
 Worm   348 VFLGLSTVSSNHHWDTSFIVLTVVFCLIYRTLGVVVMCYFLNKYRLNKYTKVDQFIMAYGGLRGA 412

  Fly   559 VAFALVLLVDENVVKQKNMFVTTTIAVIYFTVFLQGITIKPLVKILNVKRANKRKPTMNERIHER 623
            :|:.||:.:.: .:..||||||:.|.||||||||||||:||:.:.|.|::.|.....|.|.|:..
 Worm   413 IAYGLVVAIPD-FIPGKNMFVTSCIIVIYFTVFLQGITLKPIAEFLQVEKKNVHSKNMIEHIYSE 476

  Fly   624 FMDHLMAGIEDIVGKTGNYNVRDKFKRFDNRFIRPLLI--RDLKGAE-PKIIETYSKLTMRDAME 685
            .:|..|||:|||.|..|::.:||.:...:|.::||:|:  .::|..: .|::..|..|...||.:
 Worm   477 LIDTTMAGMEDIAGFKGHHWIRDSWNALNNNYLRPILVNKNNMKEMDKTKLVRKYKHLVDEDAKK 541

  Fly   686 VMRRNPSTIGQMTGTESMSALFRNYTNNYIGGSPSLTNLDNT--CSRNLDMAELDYNPSKKDLTD 748
            :.|.:.::  .|..|:::....|:.||..|.|..|.:.:|.|  ...|..:...| :.|...:|.
 Worm   542 IARGDLNS--NMVFTKALIEHTRSRTNTMIDGVSSTSKIDFTKHMKENFGVTVYD-DHSTVPMTP 603

  Fly   749 ARIHHLLAEELKPYRRHRRLSYS-RHAVDDRD 779
            .   ||..|..:       :.|| |..::|.|
 Worm   604 T---HLFQETTE-------VEYSVRSEINDND 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe2	NP_001137851.1	b_cpa1	189..704	CDD:273294	228/523 (44%)
		Na_H_Exchanger	199..602	CDD:279355	195/408 (48%)
nhx-2	NP_495614.4	Na_H_Exchanger	103..455	CDD:279355	174/354 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2218
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000129
OrthoInspector	1	1.000	-	-		otm14083
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X654
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.820