Protein Alignment Nhe2 and SLC9A6

DIOPT Version :9

• Sequence 1: NP_001137851.1
• Gene: Nhe2 / 35376
• FlyBaseID: FBgn0040297
• Length: 1322
• Species: Drosophila melanogaster
• Sequence 2: NP_001036002.1
• Gene: SLC9A6 / 10479
• HGNCID: 11079
• Length: 701
• Species: Homo sapiens
• Alignment Length: 679
• Identity: 183/679 - (26%)
• Similarity: 292/679 - (43%)
• Gaps: 168/679 - (24%)

  Fly   173 KGDEGHKMERYPLSSVDFARVKTPFIIGIWILSASIAKIGFHMTPKLHLIFPESCLLIVVGVVIG 237
            :.:|.|:.:...|  :.|..:.|..|:.||:.....|:.       ||    |:.|.::.|:::|
Human    62 QAEESHRQDSANL--LIFILLLTLTILTIWLFKHRRARF-------LH----ETGLAMIYGLLVG 113

  Fly   238 VVLYF--------------CTDVAVSPLT------------------------------------ 252
            :||.:              | :|..||.|
Human   114 LVLRYGIHVPSDVNNVTLSC-EVQSSPTTLLVNVSGKFYEYMLKGEISSHELNNVQDNEMLRKVT 177

  Fly   253 --PNTFFFYMLPPIILDAGYFMPNRLFFDNLGTILLMAVVGTIFNIATIGGSLYAC-GKMGIYGE 314
              |..||..:|||||..|||.:..|.||.|||:||..|.:||..:...||..:|.| ..|.:.|
Human   178 FDPEVFFNILLPPIIFYAGYSLKRRHFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVTG- 241

  Fly   315 SETPG---LMDVFLFASLISAVDPVAVLAVFEEIHVNEILYIVVFGESLLNDAVTVVMYHMMESY 376
             :..|   ..|..||.:::||.|||.|||:|.|:.|:..||.::||||:|||||.:|:...:.:|
Human   242 -QLAGDFYFTDCLLFGAIVSATDPVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAY 305

  Fly   377 NEIGLDKIIAQDIAS---GVGSFFVVALGGTAIGIIWGFLTGLVTRFTD--HVRVIEPIFIFVMA 436
            ...| |.....|:.:   .:|.|..:..|..|:|...|.:|.|||:||.  ..:::|....|:|:
Human   306 QPAG-DNSHTFDVTAMFKSIGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMS 369

  Fly   437 YLAYLNAEIFHMSGILAITFCGITMKNYVESNISQKSHTTVKYALKMLSSSAETIIFMFLGVA-- 499
            :..:|.||.:..:|::|:.|||||..:|..:|:|.:|....|...::|:..||..||.::|:.
Human   370 WSTFLLAEAWGFTGVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLF 434

  Fly   500 TVNNMHVWNTWFVVLTIAFCSVF--RVIGVILLSALANRFRLHKLSRVDQFVMSYGGLRGAVAFA 562
            |..| ||:|..|||  .||.::|  |...:..||.|.|..|..|:....|.:|.:.|||||:|||
Human   435 TFQN-HVFNPTFVV--GAFVAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFA 496

  Fly   563 LVLLVDENVVKQKNMFVTTTIAVIYFTVFLQGITIKPLVKILNVK------------RANKRKPT 615
            |.  :.:.....:.|..:||:.:::|||::.|.....::..|:::            ..|:|:.|
Human   497 LA--IRDTATYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDSDQEHLGVPENERRTT 559

  Fly   616 MNERIHERFMDHLMAGIEDIVGKTGNYNVRDKFKRFDNRFIRPLLI------------------- 661
            ..|   ..::..:.            ||       ||:.:::|||.
Human   560 KAE---SAWLFRMW------------YN-------FDHNYLKPLLTHSGPPLTTTLPACCGPIAR 602

  Fly   662 -----------RDLKGAEPKIIETYSKLTMRDAMEVMRRNPSTIG---QMTGTESMSALFRNYT- 711
                       ..||..:..:|.....:::......:...|:|..   :..|..|..||.|...
Human   603 CLTSPQAYENQEQLKDDDSDLILNDGDISLTYGDSTVNTEPATSSAPRRFMGNSSEDALDRELAF 667

  Fly   712 ---NNYIGGS----------PSLTNLDNT 727
               ...|.|:          |.|..||||
Human   668 GDHELVIRGTRLVLPMDDSEPPLNLLDNT 696

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe2	NP_001137851.1	b_cpa1	189..704	CDD:273294	169/624 (27%)
		Na_H_Exchanger	199..602	CDD:279355	147/467 (31%)
SLC9A6	NP_001036002.1	NhaP2	93..583	CDD:330436	156/531 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000129
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810