Protein Alignment Nhe2 and slc9a2

DIOPT Version :10

• Sequence 1: NP_001137851.1
• Gene: Nhe2 / 35376
• FlyBaseID: FBgn0040297
• Length: 1322
• Species: Drosophila melanogaster
• Sequence 2: XP_004911848.1
• Gene: slc9a2 / 101732511
• XenbaseID: XB-GENE-22069122
• Length: 791
• Species: Xenopus tropicalis
• Alignment Length: 772
• Identity: 316/772 - (40%)
• Similarity: 456/772 - (59%)
• Gaps: 104/772 - (13%)

  Fly    97 LLICALALILGSAQARPNTSAVGVAPRKVSQDIVDAVTQLNLGQSAPIDAVDVGLDPTPSARVPR 161
            |:.|.:..:|...||..:.|:.|     .|..|..:...:.:|::
 Frog    16 LVSCVIPFVLFIPQALASVSSSG-----TSSAITSSKNDVTVGET-------------------- 55

  Fly   162 PEPLKSGDENAKGDEGHKMERYPLSSVDFARVKTPFIIGIWILSASIAKIGFHMTPKLHLIFPES 226
                                |..:.::|:..|:.||.|.:|||.||:||||||:..|||.|.|||
 Frog    56 --------------------RLSVFTLDYPHVQIPFEITLWILLASLAKIGFHLYQKLHTIVPES 100

  Fly   227 CLLIVVGVVIGVVLYFCTDVAVSPLTPNTFFFYMLPPIILDAGYFMPNRLFFDNLGTILLMAVVG 291
            ||||:||:|:|.:::...:.:...:..:.||.|:||||:||||||:|.|.||||.|||...||||
 Frog   101 CLLILVGLVLGGIMFGVNEKSPPAMKTDVFFLYLLPPIVLDAGYFLPTRPFFDNAGTIFWYAVVG 165

  Fly   292 TIFNIATIGGSLYACGKMGIYGESETPGLMDVFLFASLISAVDPVAVLAVFEEIHVNEILYIVVF 356
            |::|...||.||:...::..:|.:.. .|:...||.||||||||||||||||.|||||.|||:||
 Frog   166 TLWNAIGIGISLFGICQIEAFGLTNI-SLLQCLLFGSLISAVDPVAVLAVFENIHVNEQLYILVF 229

  Fly   357 GESLLNDAVTVVMYHMMESYNEIGLDKIIAQDIASGVGSFFVVALGGTAIGIIWGFLTGLVTRFT 421
            ||||||||||||:|::.:|:.|  :..|...|:.||:...|:|.:||..||||:||:....||||
 Frog   230 GESLLNDAVTVVLYNLFKSFCE--MKTIETSDVFSGIAILFLVGIGGFFIGIIFGFVAAFTTRFT 292

  Fly   422 DHVRVIEPIFIFVMAYLAYLNAEIFHMSGILAITFCGITMKNYVESNISQKSHTTVKYALKMLSS 486
            .::|||||:|:|:.:||:||.||:||:|||:|||.|.::||.|||.|:||||:||:||.:|||||
 Frog   293 RNIRVIEPLFVFLYSYLSYLTAEMFHLSGIVAITTCAVSMKKYVEENVSQKSYTTIKYFMKMLSS 357

  Fly   487 SAETIIFMFLGVATVNNMHVWNTWFVVLTIAFCSVFRVIGVILLSALANRFRLHKLSRVDQFVMS 551
            .:||:||:|:||:||...|.||..||..|:.||..:|..||.:|:.|.|.||...|:..|||:::
 Frog   358 VSETLIFIFMGVSTVGQNHEWNWAFVCFTLFFCLFWRAAGVFILTQLINFFRTIPLTMKDQFIIA 422

  Fly   552 YGGLRGAVAFALVLLVDENVVKQKNMFVTTTIAVIYFTVFLQGITIKPLVKILNVKRANKRKPTM 616
            |||||||:.||||.|:.::|..:||:|:|..|.||:||||:|||||:|||:.||||||:|::..:
 Frog   423 YGGLRGAICFALVFLLPDSVFPRKNLFITAVIVVIFFTVFIQGITIRPLVEFLNVKRADKKQQII 487

  Fly   617 NERIHERFMDHLMAGIEDIVGKTGNYNVRDKFKRFDNRFIRPLLIRDLKGAEP--KIIETYSKLT 679
            :|.||.||:||:.||:|||.|..|:...:||||:||.:|:|.|||::   .||  .|:..|.||.
 Frog   488 SEEIHSRFLDHVKAGVEDICGHWGHNYCKDKFKKFDEKFLRKLLIKE---NEPTSSIVSLYKKLE 549

  Fly   680 MRDAMEVMRRNPSTIGQMTGTESMSALFRNYTNNYIGGSPSLTNLDNTCSRNLDMAELDYNPSK- 743
            ::.|:|:..         ||               :...|||::|..            |...|
 Frog   550 IKQAIEMAE---------TG---------------LSRDPSLSSLST------------YEKQKV 578

  Fly   744 KDLTDARIH---HLLAEELKPYR-RHRRLSYSRHAVDDRDLSTQVNYKMQMNFRRMFNDRKHHKR 804
            |.|:...::   .:|.:.|  |: |.|.|||:||.:..   .|......::..||..:.|:..|:
 Frog   579 KPLSPTEVNDMRDMLTKNL--YQIRQRTLSYNRHNLAG---GTSEKQAKEILIRRRHSMRESLKK 638

  Fly   805 ----SKRGASNKEAKENVKQNHVSFHDFQQNGTTKQLTNG-TESSSNHSRKKSYRKR 856
                |:|.|:..:|:......|....:......|...|.| ::|.|::|.:.::..|
 Frog   639 SSLNSRRAATVHQARYLSLPGHTKLFEGPTGKKTTSFTVGDSDSDSSYSTQLNFHPR 695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe2	NP_001137851.1	Na_H_Exchanger	189..704	CDD:470090	270/516 (52%)
slc9a2	XP_004911848.1	b_cpa1	63..618	CDD:273294	289/601 (48%)