DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nhe2 and slc9a2

DIOPT Version :9

Sequence 1:	NP_001137851.1	Gene:	Nhe2 / 35376	FlyBaseID:	FBgn0040297	Length:	1322	Species:	Drosophila melanogaster
Sequence 2:	XP_004911848.1	Gene:	slc9a2 / 101732511	XenbaseID:	XB-GENEPAGE-22069121	Length:	791	Species:	Xenopus tropicalis

Alignment Length:	772	Identity:	316/772 - (40%)
Similarity:	456/772 - (59%)	Gaps:	104/772 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 LLICALALILGSAQARPNTSAVGVAPRKVSQDIVDAVTQLNLGQSAPIDAVDVGLDPTPSARVPR 161
            |:.|.:..:|...||..:.|:.|     .|..|..:...:.:|::
Frog    16 LVSCVIPFVLFIPQALASVSSSG-----TSSAITSSKNDVTVGET-------------------- 55

  Fly   162 PEPLKSGDENAKGDEGHKMERYPLSSVDFARVKTPFIIGIWILSASIAKIGFHMTPKLHLIFPES 226
                                |..:.::|:..|:.||.|.:|||.||:||||||:..|||.|.|||
Frog    56 --------------------RLSVFTLDYPHVQIPFEITLWILLASLAKIGFHLYQKLHTIVPES 100

  Fly   227 CLLIVVGVVIGVVLYFCTDVAVSPLTPNTFFFYMLPPIILDAGYFMPNRLFFDNLGTILLMAVVG 291
            ||||:||:|:|.:::...:.:...:..:.||.|:||||:||||||:|.|.||||.|||...||||
Frog   101 CLLILVGLVLGGIMFGVNEKSPPAMKTDVFFLYLLPPIVLDAGYFLPTRPFFDNAGTIFWYAVVG 165

  Fly   292 TIFNIATIGGSLYACGKMGIYGESETPGLMDVFLFASLISAVDPVAVLAVFEEIHVNEILYIVVF 356
            |::|...||.||:...::..:|.:.. .|:...||.||||||||||||||||.|||||.|||:||
Frog   166 TLWNAIGIGISLFGICQIEAFGLTNI-SLLQCLLFGSLISAVDPVAVLAVFENIHVNEQLYILVF 229

  Fly   357 GESLLNDAVTVVMYHMMESYNEIGLDKIIAQDIASGVGSFFVVALGGTAIGIIWGFLTGLVTRFT 421
            ||||||||||||:|::.:|:.|  :..|...|:.||:...|:|.:||..||||:||:....||||
Frog   230 GESLLNDAVTVVLYNLFKSFCE--MKTIETSDVFSGIAILFLVGIGGFFIGIIFGFVAAFTTRFT 292

  Fly   422 DHVRVIEPIFIFVMAYLAYLNAEIFHMSGILAITFCGITMKNYVESNISQKSHTTVKYALKMLSS 486
            .::|||||:|:|:.:||:||.||:||:|||:|||.|.::||.|||.|:||||:||:||.:|||||
Frog   293 RNIRVIEPLFVFLYSYLSYLTAEMFHLSGIVAITTCAVSMKKYVEENVSQKSYTTIKYFMKMLSS 357

  Fly   487 SAETIIFMFLGVATVNNMHVWNTWFVVLTIAFCSVFRVIGVILLSALANRFRLHKLSRVDQFVMS 551
            .:||:||:|:||:||...|.||..||..|:.||..:|..||.:|:.|.|.||...|:..|||:::
Frog   358 VSETLIFIFMGVSTVGQNHEWNWAFVCFTLFFCLFWRAAGVFILTQLINFFRTIPLTMKDQFIIA 422

  Fly   552 YGGLRGAVAFALVLLVDENVVKQKNMFVTTTIAVIYFTVFLQGITIKPLVKILNVKRANKRKPTM 616
            |||||||:.||||.|:.::|..:||:|:|..|.||:||||:|||||:|||:.||||||:|::..:
Frog   423 YGGLRGAICFALVFLLPDSVFPRKNLFITAVIVVIFFTVFIQGITIRPLVEFLNVKRADKKQQII 487

  Fly   617 NERIHERFMDHLMAGIEDIVGKTGNYNVRDKFKRFDNRFIRPLLIRDLKGAEP--KIIETYSKLT 679
            :|.||.||:||:.||:|||.|..|:...:||||:||.:|:|.|||::   .||  .|:..|.||.
Frog   488 SEEIHSRFLDHVKAGVEDICGHWGHNYCKDKFKKFDEKFLRKLLIKE---NEPTSSIVSLYKKLE 549

  Fly   680 MRDAMEVMRRNPSTIGQMTGTESMSALFRNYTNNYIGGSPSLTNLDNTCSRNLDMAELDYNPSK- 743
            ::.|:|:..         ||               :...|||::|..            |...|
Frog   550 IKQAIEMAE---------TG---------------LSRDPSLSSLST------------YEKQKV 578

  Fly   744 KDLTDARIH---HLLAEELKPYR-RHRRLSYSRHAVDDRDLSTQVNYKMQMNFRRMFNDRKHHKR 804
            |.|:...::   .:|.:.|  |: |.|.|||:||.:..   .|......::..||..:.|:..|:
Frog   579 KPLSPTEVNDMRDMLTKNL--YQIRQRTLSYNRHNLAG---GTSEKQAKEILIRRRHSMRESLKK 638

  Fly   805 ----SKRGASNKEAKENVKQNHVSFHDFQQNGTTKQLTNG-TESSSNHSRKKSYRKR 856
                |:|.|:..:|:......|....:......|...|.| ::|.|::|.:.::..|
Frog   639 SSLNSRRAATVHQARYLSLPGHTKLFEGPTGKKTTSFTVGDSDSDSSYSTQLNFHPR 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nhe2	NP_001137851.1	b_cpa1	189..704	CDD:273294	270/516 (52%)
Nhe2	NP_001137851.1	Na_H_Exchanger	199..602	CDD:279355	223/402 (55%)
slc9a2	XP_004911848.1	b_cpa1	63..618	CDD:273294	289/601 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000129
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010