Protein Alignment Nhe2 and slc9a5

DIOPT Version :10

• Sequence 1: NP_001137851.1
• Gene: Nhe2 / 35376
• FlyBaseID: FBgn0040297
• Length: 1322
• Species: Drosophila melanogaster
• Sequence 2: XP_002931737.2
• Gene: slc9a5 / 100497776
• XenbaseID: XB-GENE-484916
• Length: 887
• Species: Xenopus tropicalis
• Alignment Length: 1048
• Identity: 380/1048 - (36%)
• Similarity: 543/1048 - (51%)
• Gaps: 214/1048 - (20%)

  Fly   162 PEPLKSGD-----ENAKGDEGHKMERYPLSSVDFARVKTPFIIGIWILSASIAKIGFHMTPKLHL 221
            |.||.||.     |:| ..||.::.|:     ::..|:.|:::.:|||.||:|||.||::.|:..
 Frog    12 PAPLVSGTPTEYREDA-APEGFQVVRW-----EWHTVQAPYLVAVWILVASLAKIVFHLSRKVTT 70

  Fly   222 IFPESCLLIVVGVVIGVVLYFCTDVAVSPLTPNTFFFYMLPPIILDAGYFMPNRLFFDNLGTILL 286
            :.|||||||::|:.:|.::......|...|.||.||.::||||:||:|||||:||||||:|.||:
 Frog    71 VVPESCLLIILGLALGGIVLAIAQRAQFQLEPNMFFLFLLPPIVLDSGYFMPSRLFFDNIGAILM 135

  Fly   287 MAVVGTIFNIATIGGSLYACGKMGIYGESETPGLMDVFLFASLISAVDPVAVLAVFEEIHVNEIL 351
            .||||||:|....|.:|:....:|:.......||||..||.|||||||||||||||||:||||.|
 Frog   136 YAVVGTIWNSFATGAALWGVKLVGLMDSQVNAGLMDFLLFGSLISAVDPVAVLAVFEEVHVNETL 200

  Fly   352 YIVVFGESLLNDAVTVVMYHMMESYNEIGLDKIIAQDIASGVGSFFVVALGGTAIGIIWGFLTGL 416
            :|:||||||||||||||:|.:..|:.|:|.:.:...|...||||||||::||||||:::.||..|
 Frog   201 FIIVFGESLLNDAVTVVLYKVFNSFVEMGPENVKPMDYLKGVGSFFVVSIGGTAIGLVFAFLLAL 265

  Fly   417 VTRFTDHVRVIEPIFIFVMAYLAYLNAEIFHMSGILAITFCGITMKNYVESNISQKSHTTVKYAL 481
            :||||..||:|||:|||::.|||:|.||:..:|.|||:||||:..|.|||:|||.||.|||||.:
 Frog   266 ITRFTKRVRIIEPLFIFLIVYLAHLTAEMVSLSSILAVTFCGLCCKKYVEANISNKSRTTVKYTM 330

  Fly   482 KMLSSSAETIIFMFLGVATVN-NMHVWNTWFVVLTIAFCSVFRVIGVILLSALANRFRLHKLSRV 545
            |.|:||:|||||:|||::.|: :..:|:|..|:.|:.|...||.:||||.:.:.|||||..|.::
 Frog   331 KTLASSSETIIFIFLGISAVDTSKWMWDTALVLSTLIFILTFRAVGVILQTCVLNRFRLLPLDKI 395

  Fly   546 DQFVMSYGGLRGAVAFALVLLVDENVVKQKNMFVTTTIAVIYFTVFLQGITIKPLVKILNVKRAN 610
            ||.||||||||||||||||:|:|.:.||.|:.||.|||.|::|||..||:|||||||.|.|||.:
 Frog   396 DQVVMSYGGLRGAVAFALVILLDGSKVKAKDYFVATTIVVVFFTVMFQGLTIKPLVKWLKVKRCD 460

  Fly   611 KRKPTMNERIHERFMDHLMAGIEDIVGKTGNYNVRDKFKRFDNRFIRPLLIRDLKGA---EPKII 672
            ..|||:||.:||...||:||.:|||||..|.::.|||:::||.:::...|:|  |.|   :.:|.
 Frog   461 HHKPTLNEELHEHAFDHIMAAVEDIVGHHGYHHWRDKWEQFDKKYLSQWLMR--KSAYRIKDEIW 523

  Fly   673 ETYSKLTMRDAM-------EVMRRNPSTIGQMTGTESMSALFRNYTNNYIGGSPSLTNL--DNTC 728
            |...||.:|||:       .::..:..::..|....|||             ..|:|||  :|..
 Frog   524 EVCYKLNIRDALTLADQGGHIVSPDRLSLPSMPSRASMS-------------ETSVTNLLRENGS 575

  Fly   729 SRNLDMAELDYNPSKKDLTDARIHHLLAEELKPYRRHRRLSYSRHAVDDRDLSTQVNYKMQMNFR 793
            ...||:..:|...|.||..||.:||:|...|...||..:..||||.:...:.:.|.....|.|.:
 Frog   576 KACLDLQAIDTVRSGKDKEDAVMHHVLRGSLYKTRRRCKAHYSRHFMTPDEQARQEKEVFQQNMK 640

  Fly   794 R---MFNDRKHHKRSKRGASNKEAKENVKQNHVSFHDFQQNGTTKQLTNGTESSSNHSRKKSYRK 855
            |   .|...||:..|.:..:.|:.::.           ::|.....|.||.|:..:.....|
 Frog   641 RRLESFKSTKHNICSSKSRAKKDGRKK-----------RRNSLEVDLRNGRENKISWQSTAS--- 691

  Fly   856 RHTHNSLNKYRRLEIAEECQQNPNEINVVGPSDDWDDGLTFTAKSSPDSDRANNNSLIAHIQNLP 920
                        :.:..:.::..:.|.|     :.|:|:||.|:::.:.              |.
 Frog   692 ------------IVVTADSEEESSNIEV-----EEDEGITFVARATDEI--------------LQ 725

  Fly   921 GFDASKARIVVQHYAPKADDNPDTDIESPEQAIGPTAAELILPWRRDRSYQSIVAEHPIPEEDRN 985
            |..||....:.|               ||                           |.:|
 Frog   726 GVKASSMLGICQ---------------SP---------------------------HIVP----- 743

  Fly   986 LSRESDGERRVATPTATESQLPWKRQGDECTDAVQQNEFPAWASNKEYLAYNSPSATFLGGINKP 1050
                       .:||..|..||||.:.||.|..:                  |..:|.:..::..
 Frog   744 -----------PSPTLAEKVLPWKTEPDENTVCI------------------SSESTKIVPVDLQ 779

  Fly  1051 KQPKSVIGLFRRESSSSKAGSVGVGSTGAMDSAASGSETMVVSMSSQPPNAPSTSIHNPRLDKRS 1115
            |..|..|       ||.::    :||...:|               .|.:|.:..:   |.|.||
 Frog   780 KSWKQSI-------SSLES----IGSPPVLD---------------MPQDASAKCL---RQDVRS 815

  Fly  1116 QSI------------SSSSLGAGAHQLGPEGHSGPFPVTASHRRNVRRGSMLELSGDTIPEESSY 1168
            .|:            .|:|.|...     ..|..|.||.....:     .::...|.|.....:.
 Frog   816 PSVLQTLPETCSCFPFSNSTGQNV-----TVHLDPMPVQEQELQ-----PLMPRGGGTSVSPLAS 870

  Fly  1169 QHGHSKSL 1176
            :|.|||.|
 Frog   871 RHSHSKRL 878

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe2	NP_001137851.1	Na_H_Exchanger	189..704	CDD:470090	273/525 (52%)
slc9a5	XP_002931737.2	Na_H_Exchanger	38..626	CDD:470090	298/602 (50%)