DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nhe2 and slc9a6

DIOPT Version :9

Sequence 1:	NP_001137851.1	Gene:	Nhe2 / 35376	FlyBaseID:	FBgn0040297	Length:	1322	Species:	Drosophila melanogaster
Sequence 2:	XP_002932638.3	Gene:	slc9a6 / 100497414	XenbaseID:	XB-GENE-6048314	Length:	707	Species:	Xenopus tropicalis

Alignment Length:	783	Identity:	204/783 - (26%)
Similarity:	324/783 - (41%)	Gaps:	206/783 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 PQIAP--AKRNSSCTSSDWRGMFSKRTLLICALALILGSAQARPNTSAVGVAPRKVSQDIVDAVT 134
            |.:||  |.:..|.....|       |:|:..|||.|..|.|:.:.             |.:.||
Frog    25 PVMAPLVAMKPGSRGRKAW-------TMLLLLLALALDRAGAQDSV-------------IEEIVT 69

  Fly   135 QLNLGQSAPIDAVDVGLDPTPSARVPRPEPLKSGDENAKGDEGHKMERYPLSSVDFARVKTPFII 199
            :..:..|...|:.::                                      :.|..:.|..|:
Frog    70 EKQVEASHRQDSANL--------------------------------------LVFILLLTLTIL 96

  Fly   200 GIWILSASIAKIGFHMTPKLHLIFPESCLLIVVGVVIGVVLYF--------------CTDVAVSP 250
            .||:......:.       ||    |:.|.::.|::.||||.:              | ::..||
Frog    97 TIWLFKHRRFRF-------LH----ETGLAMIYGLIAGVVLRYGIHVPSDVNNVTMSC-ELQTSP 149

  Fly   251 LT--------------------------------------PNTFFFYMLPPIILDAGYFMPNRLF 277
            .|                                      ...||..:|||||..|||.:..|.|
Frog   150 ATLLVNVSGKFYEYMLKGEISSKALNNVQDNDMLRKVTFDTEVFFNILLPPIIFYAGYSLKRRHF 214

  Fly   278 FDNLGTILLMAVVGTIFNIATIGGSLYACGKMGIYGESETPGLM-------DVFLFASLISAVDP 335
            |.|:|:||..|.:||..:...||..||.|.|:     .:..|.:       |...|.::|||.||
Frog   215 FRNMGSILAYAFLGTAISCLVIGALLYGCVKL-----MKVTGTLDGDFYFTDCLFFGAIISATDP 274

  Fly   336 VAVLAVFEEIHVNEILYIVVFGESLLNDAVTVVMYHMMESYNEIGLDKIIAQDIAS---GVGSFF 397
            |.|||:|.|:||:..||.::||||:|||||.:|:...:.:|...| |.....||.:   .:|.|.
Frog   275 VTVLAIFHELHVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAG-DNSHTFDITAMFKCIGMFL 338

  Fly   398 VVALGGTAIGIIWGFLTGLVTRFTD--HVRVIEPIFIFVMAYLAYLNAEIFHMSGILAITFCGIT 460
            .:..|..|:|...|.:|.|||:||.  ...::|....|:|::..:|.||....:|::|:.|||||
Frog   339 GIFSGSFAMGAATGVVTSLVTKFTKLREFPLLETGLFFLMSWSTFLLAEACGYTGVVAVLFCGIT 403

  Fly   461 MKNYVESNISQKSHTTVKYALKMLSSSAETIIFMFLGVA--TVNNMHVWNTWFVVLTIAFCSVF- 522
            ..:|..:|:|.:|....|...::|:..||..||.::|:|  |..| ||:|..|:|  .||.:||
Frog   404 QAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLALFTFQN-HVFNPTFIV--GAFLAVFL 465

  Fly   523 -RVIGVILLSALANRFRLHKLSRVDQFVMSYGGLRGAVAFALVLLVDENVVKQKNMFVTTTIAVI 586
             |...:..||.|.|..|.:|:....|.:|.:.|||||:||||.  :.:.....:.|..:||:.::
Frog   466 GRAANIYPLSFLLNLGRKNKIGSNFQHMMMFAGLRGAMAFALA--IRDTATYARQMMFSTTLLIV 528

  Fly   587 YFTVFLQGITIKPLVKILNVK------------RANKRKPTMNERIHERFMDHLMAGIEDIVGKT 639
            :|||::.|.....::..::::            ..|:|:.|..|   ..::..|.
Frog   529 FFTVWVFGGGTTAMLSCMHIRVGVDSEIDQMAIPENERRSTKAE---SAWIFRLW---------- 580

  Fly   640 GNYNVRDKFKRFDNRFIRPLLIRD---LKGAEPKIIETYSK-LTMRDA---MEVMRRNPSTI--- 694
              ||       ||:.:::|||...   |....|......:: ||...|   .|.::.:.|.:
Frog   581 --YN-------FDHNYLKPLLTHSGPPLTATLPSCCGPLARCLTSPQAYENQEQLKDDDSDLILN 636

  Fly   695 -GQMTGTESMSALFRNYTNNYIGGSPSLTNLDNTCSRNLDMAELDYNPSKKDLTDARIHHLLAEE 758
             |.::.|...|.:....||       ||......|:.  |..:.|....:.:|. .|...|:.||
Frog   637 DGDISLTYGDSTISTEDTN-------SLRRGTGNCAE--DALDRDLTCGEHELV-LRGTRLVMEE 691

  Fly   759 LKP 761
            .:|
Frog   692 SEP 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nhe2	NP_001137851.1	b_cpa1	189..704	CDD:273294	171/605 (28%)
Nhe2	NP_001137851.1	Na_H_Exchanger	199..602	CDD:279355	147/470 (31%)
slc9a6	XP_002932638.3	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000129
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910