Protein Alignment Nhe2 and slc9a1

DIOPT Version :10

• Sequence 1: NP_001137851.1
• Gene: Nhe2 / 35376
• FlyBaseID: FBgn0040297
• Length: 1322
• Species: Drosophila melanogaster
• Sequence 2: XP_002934703.2
• Gene: slc9a1 / 100496739
• XenbaseID: XB-GENE-484313
• Length: 771
• Species: Xenopus tropicalis
• Alignment Length: 836
• Identity: 315/836 - (37%)
• Similarity: 468/836 - (55%)
• Gaps: 129/836 - (15%)

  Fly    98 LICALALILGSAQARPNTSAVGVAPRKVSQDIVDAVTQLNLGQSAPIDAVDVGLDPTPSARVPRP 162
            ::..:.|:...|...|.:...|:.                       ||.||.
 Frog    15 ILTLIPLVFSEASYPPESGHPGIT-----------------------DAYDVF------------ 44

  Fly   163 EPLKSGDENAKGDEGH--KMERYPLSSVDFARVKTPFIIGIWILSASIAKIGFHMTPKLHLIFPE 225
            |.......|...:.||  |.:.:|:..:|:.|::.||.|.:|||.||:.|:|||:.|.|..:.||
 Frog    45 EDTHHDSTNHSHEGGHHGKKKAFPVLDLDYTRIRMPFEIALWILLASLMKLGFHVIPTLSGVVPE 109

  Fly   226 SCLLIVVGVVIGVVLYFCTDVAVSP--LTPNTFFFYMLPPIILDAGYFMPNRLFFDNLGTILLMA 288
            ||||||||:::|.::   ..|..:|  |..:.||.::|||||||||||:|.|.|.:||||||:.|
 Frog   110 SCLLIVVGLLVGGLI---KAVGETPPVLKSDVFFLFLLPPIILDAGYFLPLRPFSENLGTILMFA 171

  Fly   289 VVGTIFNIATIGGSLYACGKMGIYGES-ETPGLMDVFLFASLISAVDPVAVLAVFEEIHVNEILY 352
            |:||::|...:|..|:|..::|  ||. ...||:...||.|:|||||||||||||||||:|::|:
 Frog   172 VIGTLWNAFFMGSLLFAVCQIG--GEDLRNVGLLANLLFGSIISAVDPVAVLAVFEEIHINDLLH 234

  Fly   353 IVVFGESLLNDAVTVVMYHMMESYNEIGLDKIIAQDIASGVGSFFVVALGGTAIGIIWGFLTGLV 417
            |:||||||||||||||:||:.|.:  ..|::|..:||:.|..||.||||||..:|:::|.:....
 Frog   235 ILVFGESLLNDAVTVVLYHLFEEF--AALEQITFRDISLGFLSFLVVALGGVFVGLVYGIIAAFT 297

  Fly   418 TRFTDHVRVIEPIFIFVMAYLAYLNAEIFHMSGILAITFCGITMKNYVESNISQKSHTTVKYALK 482
            :|||.|:|||||:|:|:.:|:|||:||:||:|||:|:...|:.|:.|||:|||.|||||:||.||
 Frog   298 SRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIAAGVVMRPYVEANISHKSHTTIKYFLK 362

  Fly   483 MLSSSAETIIFMFLGVATVNNMHVWNTWFVVLTIAFCSVFRVIGVILLSALANRFRLHKLSRVDQ 547
            |.||.:||:||:||||:||...|.||..:|:.|:.||.|.||:||:.|:...|:||:.||:..||
 Frog   363 MWSSVSETLIFIFLGVSTVAGPHKWNWPYVISTLIFCFVARVLGVLGLTWFINKFRIVKLTPKDQ 427

  Fly   548 FVMSYGGLRGAVAFALVLLVDENVVKQKNMFVTTTIAVIYFTVFLQGITIKPLVKILNVKRANKR 612
            |:::|||||||:||:|..|:|:|.. .:.||:|..|.||:||||:||:||:|||::|.||:..:.
 Frog   428 FIIAYGGLRGAIAFSLGYLLDDNHF-PREMFLTAIITVIFFTVFVQGMTIRPLVELLAVKKKQES 491

  Fly   613 KPTMNERIHERFMDHLMAGIEDIVGKTGNYNVRDKFKRFDNRFIRPLLIRDLKGAEPKIIETYSK 677
            |.::||.||.:|:|||:.|||||.|..|:::.:||..||:..:::..||...:..||::|..|.|
 Frog   492 KRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFNKTYVKKCLIAGERSTEPQLIAFYHK 556

  Fly   678 LTMRDAMEVMR-----RNPSTIGQMTGTESMSALFRNYTNNYIGGSPSLT-NLDNTCSRNLDMAE 736
            :.|:.|:|::.     :.|||:    .|.||         ..|...|.|: .:..|.|:.
 Frog   557 MEMKQAIELVESGGIGKIPSTV----STVSM---------QNIQPKPKLSERIIPTLSKG----- 603

  Fly   737 LDYNPSKKDLTDARIHHLLAEELKPYRRHRRLSYSRHAVDDRDLSTQVNYKMQMNFRRMFNDRKH 801
                      .:..|..:|...|:..|:..| ||:||.:.........|   ||..||    :|.
 Frog   604 ----------KEEEIRKILRTNLQKTRQRLR-SYNRHTLVADPYEEAWN---QMLLRR----QKA 650

  Fly   802 HKRSKRGA-----------SNKEAKENVKQNHVSFHDFQQNGTTKQLTNGTESSSNHSRKKSYRK 855
            |:..:|..           |...::..|..:.:::.....:.....:|....|..:
 Frog   651 HQMEQRVTNYLTVPAHKLDSPTMSRARVGSDPLAYEPKPDSENIPTITIDPASPES--------- 706

  Fly   856 RHTHNSLNKYRRLEIAEECQQNPNEINVV-----GPSDDWDDGLTFTAKSSPDSDR 906
                        ::...|.|:...|..:.     .||...||  .|..:.||:|.|
 Frog   707 ------------VDTVNETQEEEEEAGITMTVKEPPSPGADD--VFIPQESPNSQR 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe2	NP_001137851.1	Na_H_Exchanger	189..704	CDD:470090	262/522 (50%)
slc9a1	XP_002934703.2	b_cpa1	73..637	CDD:273294	277/600 (46%)