DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nhe2 and slc9a1

DIOPT Version :9

Sequence 1:	NP_001137851.1	Gene:	Nhe2 / 35376	FlyBaseID:	FBgn0040297	Length:	1322	Species:	Drosophila melanogaster
Sequence 2:	XP_002934703.2	Gene:	slc9a1 / 100496739	XenbaseID:	XB-GENE-484313	Length:	771	Species:	Xenopus tropicalis

Alignment Length:	836	Identity:	315/836 - (37%)
Similarity:	468/836 - (55%)	Gaps:	129/836 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 LICALALILGSAQARPNTSAVGVAPRKVSQDIVDAVTQLNLGQSAPIDAVDVGLDPTPSARVPRP 162
            ::..:.|:...|...|.:...|:.                       ||.||.
Frog    15 ILTLIPLVFSEASYPPESGHPGIT-----------------------DAYDVF------------ 44

  Fly   163 EPLKSGDENAKGDEGH--KMERYPLSSVDFARVKTPFIIGIWILSASIAKIGFHMTPKLHLIFPE 225
            |.......|...:.||  |.:.:|:..:|:.|::.||.|.:|||.||:.|:|||:.|.|..:.||
Frog    45 EDTHHDSTNHSHEGGHHGKKKAFPVLDLDYTRIRMPFEIALWILLASLMKLGFHVIPTLSGVVPE 109

  Fly   226 SCLLIVVGVVIGVVLYFCTDVAVSP--LTPNTFFFYMLPPIILDAGYFMPNRLFFDNLGTILLMA 288
            ||||||||:::|.::   ..|..:|  |..:.||.::|||||||||||:|.|.|.:||||||:.|
Frog   110 SCLLIVVGLLVGGLI---KAVGETPPVLKSDVFFLFLLPPIILDAGYFLPLRPFSENLGTILMFA 171

  Fly   289 VVGTIFNIATIGGSLYACGKMGIYGES-ETPGLMDVFLFASLISAVDPVAVLAVFEEIHVNEILY 352
            |:||::|...:|..|:|..::|  ||. ...||:...||.|:|||||||||||||||||:|::|:
Frog   172 VIGTLWNAFFMGSLLFAVCQIG--GEDLRNVGLLANLLFGSIISAVDPVAVLAVFEEIHINDLLH 234

  Fly   353 IVVFGESLLNDAVTVVMYHMMESYNEIGLDKIIAQDIASGVGSFFVVALGGTAIGIIWGFLTGLV 417
            |:||||||||||||||:||:.|.:  ..|::|..:||:.|..||.||||||..:|:::|.:....
Frog   235 ILVFGESLLNDAVTVVLYHLFEEF--AALEQITFRDISLGFLSFLVVALGGVFVGLVYGIIAAFT 297

  Fly   418 TRFTDHVRVIEPIFIFVMAYLAYLNAEIFHMSGILAITFCGITMKNYVESNISQKSHTTVKYALK 482
            :|||.|:|||||:|:|:.:|:|||:||:||:|||:|:...|:.|:.|||:|||.|||||:||.||
Frog   298 SRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIAAGVVMRPYVEANISHKSHTTIKYFLK 362

  Fly   483 MLSSSAETIIFMFLGVATVNNMHVWNTWFVVLTIAFCSVFRVIGVILLSALANRFRLHKLSRVDQ 547
            |.||.:||:||:||||:||...|.||..:|:.|:.||.|.||:||:.|:...|:||:.||:..||
Frog   363 MWSSVSETLIFIFLGVSTVAGPHKWNWPYVISTLIFCFVARVLGVLGLTWFINKFRIVKLTPKDQ 427

  Fly   548 FVMSYGGLRGAVAFALVLLVDENVVKQKNMFVTTTIAVIYFTVFLQGITIKPLVKILNVKRANKR 612
            |:::|||||||:||:|..|:|:|.. .:.||:|..|.||:||||:||:||:|||::|.||:..:.
Frog   428 FIIAYGGLRGAIAFSLGYLLDDNHF-PREMFLTAIITVIFFTVFVQGMTIRPLVELLAVKKKQES 491

  Fly   613 KPTMNERIHERFMDHLMAGIEDIVGKTGNYNVRDKFKRFDNRFIRPLLIRDLKGAEPKIIETYSK 677
            |.::||.||.:|:|||:.|||||.|..|:::.:||..||:..:::..||...:..||::|..|.|
Frog   492 KRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFNKTYVKKCLIAGERSTEPQLIAFYHK 556

  Fly   678 LTMRDAMEVMR-----RNPSTIGQMTGTESMSALFRNYTNNYIGGSPSLT-NLDNTCSRNLDMAE 736
            :.|:.|:|::.     :.|||:    .|.||         ..|...|.|: .:..|.|:.
Frog   557 MEMKQAIELVESGGIGKIPSTV----STVSM---------QNIQPKPKLSERIIPTLSKG----- 603

  Fly   737 LDYNPSKKDLTDARIHHLLAEELKPYRRHRRLSYSRHAVDDRDLSTQVNYKMQMNFRRMFNDRKH 801
                      .:..|..:|...|:..|:..| ||:||.:.........|   ||..||    :|.
Frog   604 ----------KEEEIRKILRTNLQKTRQRLR-SYNRHTLVADPYEEAWN---QMLLRR----QKA 650

  Fly   802 HKRSKRGA-----------SNKEAKENVKQNHVSFHDFQQNGTTKQLTNGTESSSNHSRKKSYRK 855
            |:..:|..           |...::..|..:.:::.....:.....:|....|..:
Frog   651 HQMEQRVTNYLTVPAHKLDSPTMSRARVGSDPLAYEPKPDSENIPTITIDPASPES--------- 706

  Fly   856 RHTHNSLNKYRRLEIAEECQQNPNEINVV-----GPSDDWDDGLTFTAKSSPDSDR 906
                        ::...|.|:...|..:.     .||...||  .|..:.||:|.|
Frog   707 ------------VDTVNETQEEEEEAGITMTVKEPPSPGADD--VFIPQESPNSQR 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nhe2	NP_001137851.1	b_cpa1	189..704	CDD:273294	262/522 (50%)
Nhe2	NP_001137851.1	Na_H_Exchanger	199..602	CDD:279355	219/405 (54%)
slc9a1	XP_002934703.2	b_cpa1	73..637	CDD:273294	277/600 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000129
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10110
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100