DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9257 and MLEC

DIOPT Version :9

Sequence 1:	NP_610087.2	Gene:	CG9257 / 35375	FlyBaseID:	FBgn0032916	Length:	347	Species:	Drosophila melanogaster
Sequence 2:	NP_055545.1	Gene:	MLEC / 9761	HGNCID:	28973	Length:	292	Species:	Homo sapiens

Alignment Length:	328	Identity:	131/328 - (39%)
Similarity:	188/328 - (57%)	Gaps:	63/328 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 TWMSVLLVLVLM----------------GTFTAAEPLKVIYAVNAGGDEHTDLNGVQYDADPLKG 86
            |.:::|.:|:|:                |...|..|..||:||||||:.|.|::|:.:..|||:|
Human    10 TAVALLRLLLLLLPPAIRGPGLGVAGVAGAAGAGLPESVIWAVNAGGEAHVDVHGIHFRKDPLEG 74

  Fly    87 -VGIASDYGKHLLMIGRVQEHDEVLYRTERYHTTTFGYDLPSDGDGDYALIMKFCEVYFDAPQKK 150
             ||.|||||..|.:: |....|::||:||||:..||||::|...:|||.|::||.||||...|:|
Human    75 RVGRASDYGMKLPIL-RSNPEDQILYQTERYNEETFGYEVPIKEEGDYVLVLKFAEVYFAQSQQK 138

  Fly   151 VFDVLLNRKHTVVRQLDIYNEVGRGSAHDEIVYFKINNGRLNYEGEVSDVRNGRLRLDFIKGALD 215
            ||||.|| .|.||:.|||::.||..:|||||:...|..|:|:.:||||.. .|:|.::|:||..|
Human   139 VFDVRLN-GHVVVKDLDIFDRVGHSTAHDEIIPMSIRKGKLSVQGEVSTF-TGKLYIEFVKGYYD 201

  Fly   216 NPKINAFALLKGDISQVPRMHGTEATERIKPEGKLNAEQKKAQQVERVVRNQRDDIDEDDEDLDD 280
            |||:.|..::.|.:..||         :::|...|   :||                      ::
Human   202 NPKVCALYIMAGTVDDVP---------KLQPHPGL---EKK----------------------EE 232

  Fly   281 EEFEEELSE-QNVDKLGSDQPSLQSDTKRSYSGPRQPNPYSMDDSSILLPVFIAIGAFIPLLFCL 344
            ||.|||..| .|:.|        |::..|..||||.||||:.|:||::.|:.:|.|.|||.||||
Human   233 EEEEEEYDEGSNLKK--------QTNKNRVQSGPRTPNPYASDNSSLMFPILVAFGVFIPTLFCL 289

  Fly   345 CKL 347
            |:|
Human   290 CRL 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9257	NP_610087.2	Malectin	60..222	CDD:288557	83/162 (51%)
MLEC	NP_055545.1	Malectin	48..208	CDD:403043	83/162 (51%)
MLEC	NP_055545.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	221..265		21/76 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157090
Domainoid	1	1.000	165	1.000	Domainoid score	I3924
eggNOG	1	0.900	-	-		E1_KOG3593
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8823
Inparanoid	1	1.050	223	1.000	Inparanoid score	I3534
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49051
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006471
OrthoInspector	1	1.000	-	-		oto89057
orthoMCL	1	0.900	-	-		OOG6_106723
Panther	1	1.100	-	-	LDO	PTHR13460
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4166
SonicParanoid	1	1.000	-	-		X5440
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790