Protein Alignment l(2)05287 and NAN1

DIOPT Version :10

• Sequence 1: NP_610086.3
• Gene: l(2)05287 / 35374
• FlyBaseID: FBgn0284251
• Length: 1071
• Species: Drosophila melanogaster
• Sequence 2: NP_015199.1
• Gene: NAN1 / 855977
• SGDID: S000006047
• Length: 896
• Species: Saccharomyces cerevisiae
• Alignment Length: 735
• Identity: 155/735 - (21%)
• Similarity: 258/735 - (35%)
• Gaps: 217/735 - (29%)

  Fly     7 DRLELQFLAGG--------------NIVEHAPVFSPDGRFMFVRCLTKVQVYATSTGELTRVLDD 57
            ::.:|..::||              ||..    .|.|.|...:....:::||:..|.:..:.|..
Yeast     8 EQYKLSVVSGGKPALNNLSSVTGNKNIAR----LSQDQRNYIIPFNNQIKVYSVETRQCVKTLKF 68

  Fly    58 ATAPLIS----------------LELDLKQPD-----LLIGCTSTGELVRWNWRAGVLKKTVSLT 101
            |...|:|                |..|:..|.     |:...|:.|.::..|::..:::......
Yeast    69 ANNSLLSGIFLQEEENNESIVKILLGDITVPQQEDAHLITVFTNNGHVIVLNYKGKLVESPKHFK 133

  Fly   102 LGPGD-------------TILTCHLMDLYKGGDT-------ACAFVTAKG--KAGEQVKWFVV-- 142
            :...|             .|||.......|..::       |..|..||.  :...|.:|..|
Yeast   134 ISLADEKLANVFHSEGNYRILTTFKDPSQKAHNSLQSYRLYALTFDDAKKQFEVAHQAEWHNVIL 198

  Fly   143 -NTSTGEKI------DVNC--------------GLKLKLRVPLVDVGKGQFKYIVLAQGFYIYFV 186
             |.|:..|:      ||:.              ...:.|..||..:...|.:.:
Yeast   199 SNISSNGKLLAHMCKDVSTKDHEHKSISVVSLFDDSVNLSFPLGSILSSQTQSL----------- 252

  Fly   187 NYETWTFCRYKSAKQHTITCVKMSPCEMVAATADSEGQIFVWRDFEKKDSMTNTLFHWHHTEVTS 251
            :|.|    ||.|:     ..:.....::....|.....|....|.:.:      |..||...|.|
Yeast   253 SYNT----RYVSS-----MAIDNMGQQLAVGFASGVISIVSLADLQIR------LLKWHIDSVLS 302

  Fly   252 LAFSPSGVSIYSGGHECVLVKWTVASPGYRKYLPRMSSVIRHIVVSDDNEN----VLVCTEDNA- 311
            |:||..|..:.|||.|.|:..|.:.: ..:::|||::.:|....|.....|    :|..||:|:
Yeast   303 LSFSHDGSYLLSGGWEKVMSLWQLET-NSQQFLPRLNGIIIDCQVLGPQGNYYSLILQMTENNSN 366

  Fly   312 ----IQLISGSD-----------NIIKSTVQHF-----TYETKD-------------------KT 337
                ..|::.||           .:..||::|.     ...||:                   |:
Yeast   367 SDYQFLLLNASDLTSKLSINGPLPVFNSTIKHIQQPISAMNTKNSNSITSLNHSKKKQSRKLIKS 431

  Fly   338 GQSKFPLGLRLNPRTNTLVLNGRSGHLQFYSAYTKSLLYNLRVVDTNVHNE------EAN---HI 393
            .:..|...:.:||....|.....|. :|.:..| |:...|.:.:.:.|:|.      |.|   .|
Yeast   432 RRQDFTTNVEINPINKNLYFPHISA-VQIFDFY-KNEQVNYQYLTSGVNNSMGKVRFELNLQDPI 494

  Fly   394 IYNTRITRAAFNINWMATGEVY---NDLVNFAEVR--LKFWHYNERLQSYILNTEIELPHENGFK 453
            |.:.:.|:..   .||.|.|:.   |||::..::.  ||||..|:...::.|.|::..||  |..
Yeast   495 ITDLKFTKDG---QWMITYEIEYPPNDLLSSKDLTHILKFWTKNDNETNWNLKTKVINPH--GIS 554

  Fly   454 ---AIIFSNQFQVDNLR-CATAGEDNVVKVWCITDSENIYKRGTMWSCLAQTSYRNL----PIGS 510
               ..|..:...|:|.: |.||..:..:|.|.....|      :.| ||.:.|..|.    ...|
Yeast   555 VPITKILPSPRSVNNSQGCLTADNNGGLKFWSFDSHE------SNW-CLKKISLPNFNHFSNSVS 612

  Fly   511 LCFSQDGSLLAVGYGNTLALYDARNPRLPLQTLSCPPGLDGVISKAQLRLAQTPLNGARKEFTQQ 575
            |.:||||||:..|:.:.|.:.|                .|.......|...:|.     .|||..
Yeast   613 LAWSQDGSLIFHGFDDKLQILD----------------FDTFKKFESLENTKTV-----SEFTLD 656

  Fly   576 RQQLWALLKTLLNSNDENLI 595
            .:     ::|:...||.|||
Yeast   657 SE-----IQTVKLINDTNLI 671

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)05287	NP_610086.3	WD40	<25..314	CDD:441893	71/363 (20%)
		WD40	<201..535	CDD:441893	95/399 (24%)
		WD40 repeat	205..244	CDD:293791	4/38 (11%)
		WD40 repeat	249..285	CDD:293791	12/35 (34%)
		WD40 repeat	292..330	CDD:293791	12/62 (19%)
		WD40 repeat	343..389	CDD:293791	10/51 (20%)
		WD40 repeat	403..445	CDD:293791	14/46 (30%)
		WD40 repeat	452..480	CDD:293791	7/31 (23%)
		WD40 repeat	508..531	CDD:293791	10/22 (45%)
NAN1	NP_015199.1	WD40	<250..>353	CDD:441893	28/129 (22%)
		WD40 repeat	260..295	CDD:293791	5/45 (11%)
		WD40 repeat	300..326	CDD:293791	12/25 (48%)