DRSC/TRiP Functional Genomics Resources

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Protein Alignment l(2)05287 and WDR75

DIOPT Version :10

Sequence 1:NP_610086.3 Gene:l(2)05287 / 35374 FlyBaseID:FBgn0284251 Length:1071 Species:Drosophila melanogaster
Sequence 2:NP_115544.1 Gene:WDR75 / 84128 HGNCID:25725 Length:830 Species:Homo sapiens


Alignment Length:1076 Identity:251/1076 - (23%)
Similarity:399/1076 - (37%) Gaps:330/1076 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 DEDRLELQFLAGGNIVEHAPVFSPDGRFMFVRCLTK--VQVYATSTGELTRVLDDATAPLISLEL 67
            :|:.:.:....|..:.....|||.|.:::|  |::.  |:||:|.|.|...:|......:..::|
Human     3 EEENIRVVRCGGSELNFRRAVFSADSKYIF--CVSGDFVKVYSTVTEECVHILHGHRNLVTGIQL 65

  Fly    68 DLKQPDLLIGCTSTGELVRWNWRAGVLKKTVSLTLGPGDTILTCHLMDLYKGGDTACAFVTAKGK 132
            :......|..|:..|.:..|::..|:|.||.         |:.|.|..|         |..|:  
Human    66 NPNNHLQLYSCSLDGTIKLWDYIDGILIKTF---------IVGCKLHAL---------FTLAQ-- 110

  Fly   133 AGEQVKWFVVNTSTGEKIDVNCGLKLKL---------------------RVPLVDVGKGQFKYIV 176
             .|...:.:||.   ||.|:...:.:||                     :.|.......:..|:.
Human   111 -AEDSVFVIVNK---EKPDIFQLVSVKLPKSSSQEVEAKELSFVLDYINQSPKCIAFGNEGVYVA 171

  Fly   177 LAQGFY--IYFVNYE-----TWTFCRYKSAKQHTITCVKMSPCEMVAATADSEGQIFVWRDFEKK 234
            ..:.||  :||...:     |.:..|.|...::..|||...|.|...|:...:|:|.:||:|...
Human   172 AVREFYLSVYFFKKKTTSRFTLSSSRNKKHAKNNFTCVACHPTEDCIASGHMDGKIRLWRNFYDD 236

  Fly   235 DSMTNTLFHWHHTEVTSLAFSPSGVSIYSGGHECVLVKWTVASPGYRKYLPRMSSVIRHIVVSDD 299
            ...|.|..||||..|..||||.:|.|:.|||.|.|||:|..|:...:::|||:.:.|.||.||..
Human   237 KKYTYTCLHWHHDMVMDLAFSVTGTSLLSGGRESVLVEWRDATEKNKEFLPRLGATIEHISVSPA 301

  Fly   300 NENVLVCTEDNAIQLISGSDNIIKSTVQHFTYE--------TKDKTGQSKFPLGLRLNPRTNTLV 356
            .:  |.||        |.|||  |..:.|...|        .||:   |.| .||.::|||..||
Human   302 GD--LFCT--------SHSDN--KIIIIHRNLEASAVIQGLVKDR---SIF-TGLMIDPRTKALV 350

  Fly   357 LNGRSGHLQFYSAYTKSLLYNLRVVDTNVHNEEANHIIYNTRITRAAFNI--NWMATGEVYNDLV 419
            |||:.|||||||..:...||||.::.....|:   :.:....:|:|||..  ||:||.|...:..
Human   351 LNGKPGHLQFYSLQSDKQLYNLDIIQQEYIND---YGLIQIELTKAAFGCFGNWLATVEQRQEKE 412

  Fly   420 NFAEVRLKFWHYNERLQSYILNTEIELPHENGFKAIIFSNQFQVDNLRCATAGEDNVVKVWCITD 484
            ...|:::|.|.||::.|.:||||:|.:|||:...|:.|.|..:.:.....||.:|...|||.:||
Human   413 TELELQMKLWMYNKKTQGFILNTKINMPHEDCITALCFCNAEKSEQPTLVTASKDGYFKVWILTD 477

  Fly   485 SENIYKRGTMWSCLAQTSYRNLPIGSLCFSQDGSLLAVGYGNTLALYDARNPRLPLQTLSCPPGL 549
            ..:|||:...|:|....||......:.|||:|||||||.:...:.::|:                
Human   478 DSDIYKKAVGWTCDFVGSYHKYQATNCCFSEDGSLLAVSFEEIVTIWDS---------------- 526

  Fly   550 DGVISKAQLRLAQTPLNGARKEFTQQRQQLWALLKTLLNSNDENLIQQAKDLIVGPPAKAKLVSE 614
                                        ..|.|                                
Human   527 ----------------------------VTWEL-------------------------------- 531

  Fly   615 PDNTTKETVFKYIMKMPELGLHQKLQLLRRFGVECSVPLAHRQRLFQHLQQRAVIPQATKLRLRK 679
                                                                             
Human   532 ----------------------------------------------------------------- 531

  Fly   680 LEFRLHRLHTRHRYKAKQRLSHVNNRRQKFENLVPQDVMNLFSVLKLDESSKPKKEKTGKCKLNG 744
                                                                       ||..  
Human   532 -----------------------------------------------------------KCTF-- 535

  Fly   745 NSKPNTKAKKIPASAAPLQGLAQISHVQFGAGDQAHLVAVCTESRVL-IWNLLTLRLQAGLKLSV 808
                             .|...:|.|:.||....:..:...||:.:| .||||:..|:...||:|
Human   536 -----------------CQRAGKIRHLCFGRLTCSKYLLGATENGILCCWNLLSCALEWNAKLNV 583

  Fly   809 RQLAFDPLTNLMAVITKN---DELHVFQPNVPLPLYQRSNLPKTHGLAW---LPRRQPRQ-SSIN 866
            |.:..||.:..:|.|:::   .:|.||:|:.|.|||.:..:.: ..:.|   :||..|.. :|..
Human   584 RVMEPDPNSENIAAISQSSVGSDLFVFKPSEPRPLYIQKGISR-EKVQWGVFVPRDVPESFTSEA 647

  Fly   867 IDWQAQSTLLMLTHSQEIAYLALPGQSPSDDAPTPISFSQPAATDIILKHATF--GIHVIKPQQA 929
            ..|..:|....||.||.:  |....:|| ::..||.|....|...:......|  |.|..:..:.
Human   648 YQWLNRSQFYFLTKSQSL--LTFSTKSP-EEKLTPTSKQLLAEESLPTTPFYFILGKHRQQQDEK 709

  Fly   930 SGESLEKNGPLIVGREEHSAVNAFVNLSAHTMPAMSLICGEFVKSLLIPADSTSRHSSSAASDAA 994
            ..|:||.....:...|...|::..::..||.:|:.:.:|..||.|||:..::.|  :.....|..
Human   710 LNETLENELVQLPLTENIPAISELLHTPAHVLPSAAFLCSMFVNSLLLSKETKS--AKEIPEDVD 772

  Fly   995 LTNGVTVNGNGVGHQDSDGEHEDEELGEEARNTLDT 1030
            :..          .::|:...|:.:..|:.::|.:|
Human   773 MEE----------EKESEDSDEENDFTEKVQDTSNT 798

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)05287NP_610086.3 WD40 <25..314 CDD:441893 89/318 (28%)
WD40 <201..535 CDD:441893 129/343 (38%)
WD40 repeat 205..244 CDD:293791 13/38 (34%)
WD40 repeat 249..285 CDD:293791 16/35 (46%)
WD40 repeat 292..330 CDD:293791 13/37 (35%)
WD40 repeat 343..389 CDD:293791 22/45 (49%)
WD40 repeat 403..445 CDD:293791 17/43 (40%)
WD40 repeat 452..480 CDD:293791 7/27 (26%)
WD40 repeat 508..531 CDD:293791 10/22 (45%)
WDR75NP_115544.1 WD 1 4..43 10/40 (25%)
WD40 <20..316 CDD:441893 94/333 (28%)
WD 2 47..86 6/38 (16%)
WD40 repeat 61..99 CDD:293791 10/46 (22%)
WD 3 90..131 16/64 (25%)
WD 4 145..184 6/38 (16%)
WD40 repeat 159..194 CDD:293791 6/34 (18%)
WD 5 193..231 10/37 (27%)
WD40 repeat 206..242 CDD:293791 12/35 (34%)
WD40 <207..525 CDD:441893 128/336 (38%)
WD 6 237..276 20/38 (53%)
WD40 repeat 251..289 CDD:293791 18/37 (49%)
WD 7 279..318 16/50 (32%)
WD40 repeat 293..317 CDD:293791 13/35 (37%)
WD 8 324..362 19/41 (46%)
WD 9 376..423 12/49 (24%)
WD40 repeat 380..432 CDD:293791 16/54 (30%)
WD 10 430..474 16/43 (37%)
WD40 repeat 445..494 CDD:293791 16/48 (33%)
WD 11 487..525 14/37 (38%)
WD40 repeat 501..524 CDD:293791 10/22 (45%)
WD 12 529..569 12/214 (6%)
WD 13 574..611 11/36 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 763..806 7/48 (15%)

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