DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9259 and CG5644

DIOPT Version :9

Sequence 1:	NP_001260658.1	Gene:	CG9259 / 35372	FlyBaseID:	FBgn0032913	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_648274.1	Gene:	CG5644 / 39029	FlyBaseID:	FBgn0035948	Length:	459	Species:	Drosophila melanogaster

Alignment Length:	482	Identity:	104/482 - (21%)
Similarity:	169/482 - (35%)	Gaps:	158/482 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 TSDAPAGYLGSHLYLHVTLKLHNSEEVRQLTFFSKSAPV-------------------------- 79
            |..:..||.|::.|      ..|:|.:|||  ||:|..|
  Fly    19 TVSSAGGYDGTNQY------EENAEHLRQL--FSQSKLVSFSIAHIACSAGSSSGDNYMSVVKRV 75

  Fly    80 --------------GNE-------------SRMEYLEDFGVFEKEIAVYQNVLPDL--HKACAEV 115
                          |:|             ||.:.......|..||..|:::.|.|  |.. .::
  Fly    76 TISQAGKDQDPELAGSEIVTVIVKRQIASLSRRQLYRCEEAFSNEINAYRHLAPLLAAHSR-HQL 139

  Fly   116 APKCYYADKN----------LLIFENLADQGYRMGAGRDGLLTYEQLHCCL--KTLAAMHAGSII 168
            .|.|:.|:..          :::.::|...|:||   :|.|...|...|.|  |.||.:||.|:.
  Fly   140 FPVCHIAESQDRRDAEGGEPIIVLQDLKAMGFRM---KDRLAGLELSDCLLVMKKLAQLHAASLA 201

  Fly   169 QEQRTGQKIAQSQPKSVVENAYPSDVS-----------PEHMRMVNFQNACLVLKEFIKLIPKYQ 222
            .::......| .....:.|..|..:.:           .:.:..:...||...|...|:|:.:.:
  Fly   202 AQELESSSFA-FHADHLQEIVYCDEATDFYATILDTSVQQALESLGDANADDCLTTPIRLLEELR 265

  Fly   223 SKLDYVLENFTEKMSFIFEAVKTSDVYQNTILHGDLWANNIMFQYGRYGEVPLQCRLVDFQLARY 287
            :.|   .||...:::      .|:....:.|.|||||.|||||:     ..|.:....|.|..|.
  Fly   266 TNL---FENLKHEIN------ATAAAPNSVICHGDLWVNNIMFR-----SEPEEVIFFDLQAMRK 316

  Fly   288 APPVLDVLTVLTIPTSKEFRDAHLSELLAEYYRFMTEFLKR--ADLDIARFIPEQTFYESVQKFR 350
            :.|:.|:|..:...|.:..||.|...|||.|.:.::|.|:.  .|...|..:.|.....|:|:..
  Fly   317 SSPIFDILHFIYTSTRRPLRDVHTDTLLAAYSQALSEELRHQLEDTTAAERLEELCEAFSLQRLS 381

  Fly   351 S--VGLIESCLFCHLVILP---------PH---------------CTQKLTSSVDGFNDFFTNKR 389
            |  |..:...|...:.|||         |:               |||.|||.
  Fly   382 SDYVRQVHYGLAIGMWILPAVTFDPNNLPNLDVMSEQNLTGKEIKCTQMLTSE------------ 434

  Fly   390 IEICLEAFNTDELYRSRLVDMIEDFVD 416
                         |..|:.:::.:|.:
  Fly   435 -------------YHMRIRELVMEFYE 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9259	NP_001260658.1	PKc_like	57..328	CDD:304357	78/348 (22%)
CG9259	NP_001260658.1	APH	<252..325	CDD:279908	26/72 (36%)
CG5644	NP_648274.1	EcKinase	65..357	CDD:281023	69/310 (22%)
CG5644	NP_648274.1	P-loop_NTPase	<357..435	CDD:304359	18/102 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2AMXB
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11012
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X109
	4	3.910