Protein Alignment tadr and SLC7A3

DIOPT Version :9

• Sequence 1: NP_724308.2
• Gene: tadr / 35370
• FlyBaseID: FBgn0032911
• Length: 719
• Species: Drosophila melanogaster
• Sequence 2: NP_001041629.1
• Gene: SLC7A3 / 84889
• HGNCID: 11061
• Length: 619
• Species: Homo sapiens
• Alignment Length: 712
• Identity: 124/712 - (17%)
• Similarity: 237/712 - (33%)
• Gaps: 266/712 - (37%)

  Fly     5 SLLDVLCSGSGARLALGASVISYLIVYNEASAPSLLVGVVLATVYGAMAARCKTSLRSLQMPYVR 69
            |.||::..|.|:.|..|..|::..:..::| .||:::..::|.:...:|..|.... ..::|  |
Human    33 STLDLVALGVGSTLGAGVYVLAGEVAKDKA-GPSIVICFLVAALSSVLAGLCYAEF-GARVP--R 93

  Fly    70 ATNKFDFSCL-------FLAIWLDALATVCACAALARTLSACLDAMTGGLARILILGRNAPANEP 127
            :.:.:.:|.:       |...|...|:.|...|::||..|:..|.:.|......:.|..| .:.|
Human    94 SGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAWSSAFDNLIGNHISKTLQGSIA-LHVP 157

  Fly   128 -----WPDVLGVSVVFLVTGMFMLGLEHSRAFSLILTLGMFGLNAILSAV----GWWRGDMLAWS 183
                 :||...:.:|.|:||:..||...|...:.:.|    |:|.::...    |:.:||:..|.
Human   158 HVLAEYPDFFALGLVLLLTGLLALGASESALVTKVFT----GVNLLVLGFVMISGFVKGDVHNWK 218

  Fly   184 A-------------DSY---------FQPDGISSVFLGTALLTYSFPGDWPQQLRGGRFTATLIT 226
            .             |:|         |.|.|...:..|.|...|:|.|          |.....|
Human   219 LTEEDYELAMAELNDTYSLGPLGSGGFVPFGFEGILRGAATCFYAFVG----------FDCIATT 273

  Fly   227 GLVSTSLLLTAICLSTVVHYRSQEDYVAVPLFNILDENGFHKLVPASACML-------LLTSSAA 284
            |                  ..:|....::|:       |.  ::..|.|.|       .||....
Human   274 G------------------EEAQNPQRSIPM-------GI--VISLSVCFLAYFAVSSALTLMMP 311

  Fly   285 FLELFPE-------LY------------GIVVRLATSEWRILSK-----QISYESSESG------ 319
            :.:|.||       ||            |.:..|:||   :|..     ::.|..:|.|
Human   312 YYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTS---LLGSMFPMPRVIYAMAEDGLLFRVL 373

  Fly   320 --------NPVLAVFIAGSMCAMLAFACPLQHLSYTLAAGHMGGVFLRALYLLYIPYRPKYMAPS 376
                    .|::|..::|.:.|.:||...|..|...::.|.:....|.::.:|.:.|:|.....:
Human   374 ARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRYQPDQETKT 438

  Fly   377 SESSLSYSRLSTAPFAKSSSYSSAATSSSSRLKRSLWKIGLPKHSNLKKPKTKPRNKQELEKEWL 441
            .|              :......|.|:.|.:|  :||.:..|.:|
Human   439 GE--------------EVELQEEAITTESEKL--TLWGLFFPLNS-------------------- 467

  Fly   442 LLGEPTSPCPQREGRDVESTILSDGEPPPSDFEYPDKFDKSDSDTSTDIDAIVDEYREKIKVTTA 506
                                                                             
Human   468 ----------------------------------------------------------------- 467

  Fly   507 GPLERSVRVPTVSSWRV-----TIFAIVVIGLGIALCIAGLMMHWAPAALTG-----GIGVLIVT 561
                    :||..|.::     ::.|:::    .|||:  ::..|:...|:|     .:.||::.
Human   468 --------IPTPLSGQIVYVCSSLLAVLL----TALCL--VLAQWSVPLLSGDLLWTAVVVLLLL 518

  Fly   562 IMMGFI------PKYTGSV---INVSPVICGMSLLMGVILFSGCAIHSWPGLLIWLMAGLIL 614
            :::|.|      |:.:..:   :...|::..||:.:.:.|.......:|....:|::.|..:
Human   519 LIIGIIVVIWRQPQSSTPLHFKVPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFAI 580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tadr	NP_724308.2	2A0303	5..>209	CDD:273330	55/241 (23%)
SLC7A3	NP_001041629.1	2A0303	9..591	CDD:273330	124/712 (17%)
		AA_permease_C	539..589	CDD:290617	7/42 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810