DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tadr and SLC7A14

DIOPT Version :9

Sequence 1:	NP_724308.2	Gene:	tadr / 35370	FlyBaseID:	FBgn0032911	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	NP_066000.2	Gene:	SLC7A14 / 57709	HGNCID:	29326	Length:	771	Species:	Homo sapiens

Alignment Length:	699	Identity:	147/699 - (21%)
Similarity:	272/699 - (38%)	Gaps:	177/699 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LDVLCSGSGARLALGASVISYLIVYNEASAPSLLVGVVLATVYGAMAARC---------KTSLRS 62
            :|::..|.|:.:..|..|:|.|:. .|.:.|.::|..::|.|...::..|         ||:..:
Human    56 VDLISLGVGSCVGTGMYVVSGLVA-KEMAGPGVIVSFIIAAVASILSGVCYAEFGVRVPKTTGSA 119

  Fly    63 LQMPYVRATNKFDFSCLFLAIWLDALATVCACAALARTLSACLDA---------MTGGLARILIL 118
            ....||...   :|...|:. |...|..:...||.|..||:..|:         |...:..:..|
Human   120 YTYSYVTVG---EFVAFFIG-WNLILEYLIGTAAGASALSSMFDSLANHTISRWMADSVGTLNGL 180

  Fly   119 GRNAPANEPWPDVLGVSVVFLVTGMFMLGLEHSRAFSLILTL------------GMFGLNAILSA 171
            |:   ..|.:||:|.:.:..:||.:..||:::|..|:.:|.:            |:|.:|.
Human   181 GK---GEESYPDLLALLIAVIVTIIVALGVKNSIGFNNVLNVLNLAVWVFIMIAGLFFING---- 238

  Fly   172 VGWWRGDMLAWSADSYFQPDGISSVFLGTALLTYSFPG-----------DWPQQLRGGRFTATLI 225
             .:|        |:..|.|.|.|.|..|.|...|:|.|           ..|........||:|:
Human   239 -KYW--------AEGQFLPHGWSGVLQGAATCFYAFIGFDIIATTGEEAKNPNTSIPYAITASLV 294

  Fly   226 ---TGLVSTSLLLTAICLSTVVHYRSQEDYVAVPLFNILDENGFH--KLVPASACMLLLTSSAAF 285
               |..||.|::||.:    |.:|....:   .||..:...:||:  |.|.|...:..||.| ..
Human   295 ICLTAYVSVSVILTLM----VPYYTIDTE---SPLMEMFVAHGFYAAKFVVAIGSVAGLTVS-LL 351

  Fly   286 LELFPELYGIVVRLATSEWRILSKQISYESSESGNPVLAVFIAGSMCAMLAFACPLQHLSYTLAA 350
            ..||| :..::..:|..  .:|.:.:::.||.:..||:|..::|.:.|:||....|:.|...::.
Human   352 GSLFP-MPRVIYAMAGD--GLLFRFLAHVSSYTETPVVACIVSGFLAALLALLVSLRDLIEMMSI 413

  Fly   351 GHMGGVFLRALYLLYIPYRP--------KYMA----PSSESSLS-YSRLSTAPFAKSSSYSSAAT 402
            |.:....|.::.:|.:.|:|        |:::    ...|..|: ..:.:.:|.::...:|..||
Human   414 GTLLAYTLVSVCVLLLRYQPESDIDGFVKFLSEEHTKKKEGILADCEKEACSPVSEGDEFSGPAT 478

  Fly   403 SSSSRLKRSLWKIGLPKHSNLKKPKTKPRNKQELEKEWLLLGEPTSPCPQREGRDVESTILSDGE 467
            ::..  .::|..:|                    :.|.|:            |:..:||.
Human   479 NTCG--AKNLPSLG--------------------DNEMLI------------GKSDKSTY----- 504

  Fly   468 PPPSDFEYPDKFDKSDSDTSTDIDAIVDEYREKIKVTTAGPLERSVRV----------PTVSSWR 522
                :..:|: :...|..|..:.|...:.|..|:| ...||...::|:          ||.::..
Human   505 ----NVNHPN-YGTVDMTTGIEADESENIYLIKLK-KLIGPHYYTMRIRLGLPGKMDRPTAATGH 563

  Fly   523 -VTIFAIVVIGLGIALC---IAGL-----MMHWAPAALTGGIGVLIVTIMMGFI----------- 567
             |||..:::..|....|   |.|.     ...||         :|:|.:|:..|
Human   564 TVTICVLLLFILMFIFCSFIIFGSDYISEQSWWA---------ILLVVLMVLLISTLVFVILQQP 619

  Fly   568 --PKYTGSVINVSPVICGMSLLMGVILFSGCAIHSWPGLLIWLMAGLIL 614
              ||....:....|.:...::|:.:.|....:..:|....:|...||::
Human   620 ENPKKLPYMAPCLPFVPAFAMLVNIYLMLKLSTITWIRFAVWCFVGLLI 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tadr	NP_724308.2	2A0303	5..>209	CDD:273330	55/231 (24%)
SLC7A14	NP_066000.2	2A0303	48..677	CDD:273330	147/699 (21%)
		AA_permease_C	627..677	CDD:290617	7/42 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	736..771
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3710
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43243
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.860