DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tadr and slc7a14a

DIOPT Version :9

Sequence 1:	NP_724308.2	Gene:	tadr / 35370	FlyBaseID:	FBgn0032911	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	NP_001334618.1	Gene:	slc7a14a / 566270	ZFINID:	ZDB-GENE-070912-112	Length:	785	Species:	Danio rerio

Alignment Length:	788	Identity:	161/788 - (20%)
Similarity:	306/788 - (38%)	Gaps:	176/788 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SLLDVLCSGSGARLALGASVISYLIVYNEASAPSLLVGVVLATVYGAMAARC---------KTSL 60
            |.:|::..|.|:.:..|..|:|.|:. .|.:.|.::|..::|.|...::..|         ||:.
Zfish    54 STVDLVSLGVGSCVGTGMYVVSGLVA-KEMAGPGVIVSFIIAAVASILSGVCYAEFGVRVPKTTG 117

  Fly    61 RSLQMPYVRATNKFDFSCLFLAIWLDALATVCACAALARTLSACLDAMTG-GLARILI------- 117
            .:....||...   :|...|:. |...|..:...||.|..||:..|::.. .::..:|
Zfish   118 SAYTYSYVTVG---EFVAFFIG-WNLILEYLIGTAAGASALSSMFDSLANHSISGFMINHIGTLN 178

  Fly   118 -LGRNAPANEPWPDVLGVSVVFLVTGMFMLGLEHSRAFSLILTLGMFGLNAILSAVGWWRGDMLA 181
             ||:   ..:.:||:|.:.:..|||.:..||:::|..|:.:|.:    :|.::     |...|:|
Zfish   179 GLGK---GEQSYPDILALVIGILVTVIVALGVKNSVGFNNVLNV----INLVV-----WVFIMIA 231

  Fly   182 ---------WSADSYFQPDGISSVFLGTALLTYSFPG-----------DWPQQLRGGRFTATLIT 226
                     |. :..|.|.|.|.|..|.|...|:|.|           ..|........||:|:|
Zfish   232 GLFFVSGSNWD-EGRFLPYGWSGVMQGAATCFYAFIGFDIIATTGEEAKSPNTSIPYAITASLVT 295

  Fly   227 GL---VSTSLLLTAICLSTVVHYRSQEDYVAVPLFNILDENGFH--KLVPASACMLLLTSSAAFL 286
            .|   ||.|::||.:    |.:.....|   .||..:...:||.  |.:.|...:..||.| ...
Zfish   296 CLTAYVSVSVILTLM----VPYTEIDSD---APLMEMFSLHGFQTAKYIVAIGSIAGLTVS-LLG 352

  Fly   287 ELFPELYGIVVRLATSEWRILSKQISYESSESGNPVLAVFIAGSMCAMLAFACPLQHLSYTLAAG 351
            .||| :..::..:|..  .:|.:.:::.|:.:..|.:|..::|.:.|:||....|:.|...::.|
Zfish   353 SLFP-MPRVIYAMAGD--GLLFRFLAHVSTYTETPAVACVVSGFLSALLALLVSLRDLIEMMSIG 414

  Fly   352 HMGGVFLRALYLLYIPYRPK-----YMAPSSESS--------LSYSRLSTAPFAKSSSYSSAATS 403
            .:....|.::.:|.:.|:|:     ::...||.:        ....:.:.:|.::...|....|:
Zfish   415 TLLAYTLVSVCVLLLRYQPEGDIHGFVNFLSEQNSKRKEGVLAECEKEACSPVSEGDDYGGVPTN 479

  Fly   404 SSSRLKRSLWKIGLPKHSNLKKPKTKPRNKQELEKEWLLLGEP-----TSPCPQREGRDVESTIL 463
            :..                       .:|...|....:|:|:|     |:..|.....|:.|.|.
Zfish   480 TCG-----------------------AKNLPSLGDNEMLIGKPDKSTYTASHPNYGTVDMSSGIE 521

  Fly   464 SDGEPPPSDFEYPDKFDKSDSDTSTDIDAIVDE--YREKIKVTTAGPLERSVRVPTVSSWRVTIF 526
            |               |::||.....:..::..  |..:|::...|.::|    |||::.|:...
Zfish   522 S---------------DETDSAYLLKLKKLLGPRYYTMRIRLGLPGKMDR----PTVATGRIVTR 567

  Fly   527 AIVVIGLGIALCIAGLMMH----------WAPAALTGGIGVLIVTIMMGFI------PKYTGSVI 575
            .:|::.: :..|...|::.          ||...|.  :.:|::|:::..|      ||....:.
Zfish   568 CVVLLFI-LIFCFCSLIIFGSGQIADGQWWAVLLLV--VLLLVLTLLVFIIIQQPENPKRLPYMA 629

  Fly   576 NVSPVICGMSLLMGVILFSGCAIHSWPGLLIWLMAGLILVIRCDKYCCNCFEHTTIMNAQLIPSV 640
            ...|.:...::|:.|.|....:..:|....:|...|:::......:  |.....|....:...|.
Zfish   630 PCVPFVPASAMLVNVYLMLKLSTITWIRFGVWCFVGVLIYFGYGMW--NSTLEITAREEEAHAST 692

  Fly   641 SGKSNMGSASGSA-------SNLAGP------STSIRIPR----PPKGMGVVGLPQRINEHRXQS 688
            ..:.:||.....|       |...||      ....:.|:    .|:..|:    .|::.||..|
Zfish   693 YQRYDMGVDDNFAVDDDLYPSGDQGPFQNWGKGGQQKQPQQEQSEPQSDGL----DRLDNHRTSS 753

  Fly   689 ESSEEEGE 696
            .||....:
Zfish   754 SSSHSRAK 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tadr	NP_724308.2	2A0303	5..>209	CDD:273330	56/230 (24%)
slc7a14a	NP_001334618.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	715..785		11/51 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43243
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010