DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tadr and slc7a14b

DIOPT Version :9

Sequence 1:	NP_724308.2	Gene:	tadr / 35370	FlyBaseID:	FBgn0032911	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	XP_684639.2	Gene:	slc7a14b / 556696	ZFINID:	ZDB-GENE-091113-47	Length:	756	Species:	Danio rerio

Alignment Length:	809	Identity:	166/809 - (20%)
Similarity:	299/809 - (36%)	Gaps:	210/809 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LDVLCSGSGARLALGASVISYLIVYNEASAPSLLVGVVLATVYGAMAARC---------KTSLRS 62
            :|::..|.|:.:..|..|::.|:. .|.:.|.:::..::|.|...::..|         ||:..:
Zfish    54 VDLVSLGVGSCVGTGMYVVAGLVA-KEMAGPGVILSFIIAAVASILSGVCYAEFGVRVPKTTGSA 117

  Fly    63 LQMPYVRATNKFDFSCLFLAIWLDALATVCACAALARTLSACLDAMTG-GLARILI--------L 118
            ....||...   :|...|:. |...|..:...||.|..||:..|::.. .::|.:|        |
Zfish   118 YTYSYVTVG---EFVAFFIG-WNLILEYLIGTAAGASALSSMFDSLANHTISRYMINHLGTLNGL 178

  Fly   119 GRNAPANEPWPDVLGVSVVFLVTGMFMLGLEHSRAFSLILTL------------GMFGLNAILSA 171
            |:   ..|.:||:|.:.:..:||.:..||:::|.:|:.:|.:            |:|    .||.
Zfish   179 GK---GEESYPDLLALLIALVVTVIIALGVKNSVSFNNVLNVVNLVVWVFMVLAGLF----FLSG 236

  Fly   172 VGWWRGDMLAWSADSYFQPDGISSVFLGTALLTYSFPG-----------DWPQQLRGGRFTATLI 225
            ..|..|         .|.|.|.|.|..|.|...|:|.|           ..|........||:|:
Zfish   237 ANWEGG---------RFLPYGWSGVMQGAATCFYAFIGFDIIATTGEEAKSPDTSIPYAITASLV 292

  Fly   226 TGL---VSTSLLLTAICLSTVVHYRSQEDYVAVPLFNILDENGF--HKLVPASACMLLLTSSAAF 285
            |.|   ||.|::||.:     |.|...:.  ..||..:..::||  .|.:.|...:..||.| ..
Zfish   293 TCLTAYVSVSVILTLL-----VPYNLIDG--DAPLMEMFADHGFLAGKYIVAVGAVAGLTVS-LL 349

  Fly   286 LELFPELYGIVVRLATSEWRILSKQISYESSESGNPVLAVFIAGSMCAMLAFACPLQHLSYTLAA 350
            ..||| :..::..:|..  .:|.:.:|:.|..:..||:|..::||:.|:||....|:.|...::.
Zfish   350 GSLFP-MPRVIYAMAGD--GLLFRFLSFVSPHTETPVVACAVSGSLAALLALLVSLRDLIEMMSI 411

  Fly   351 GHMGGVFLRALYLLYIPYRPKYMAPSSESSLSYSRLSTAPFAKSSSYSSAATSSSSRLKRSLWKI 415
            |.:....|.::.:|.:.|:|                      ....::|..|......:|...::
Zfish   412 GTLLAYTLVSVCVLLLRYQP----------------------DRDGFTSFLTEEEEEERRRKEEM 454

  Fly   416 GLPKHSNLKKPKTKPRNKQELEKEWLLLGE--PTSPCPQREGRDVESTILSDGEPPPSDFEYPDK 478
            ......:|..|.                ||  ..:||..:.              .||..:....
Zfish   455 MAASEKDLNSPG----------------GEEYAENPCGAKN--------------LPSKGDNETL 489

  Fly   479 FDKSDS-------------DTSTDID-------AIVDEYREKIKVTTAGPLERSVRVP----TVS 519
            .:||||             :...::|       .::..:...|::....|.......|    ||:
Zfish   490 IEKSDSGGYQSENQGYGVGENGIEVDDSDGLFKRVLGSHYYTIRMRLGLPNVSDKPTPATGRTVT 554

  Fly   520 SWRVTIFAIVVIGLGIALCIAGL-----MMHWA--PAALTGGIGVLIVTIMMGFI-----PKYTG 572
            |. |.||.|:...|. .|.|.|.     ...||  |..||  |.||:||:::..:     ||...
Zfish   555 SC-VLIFFILTFFLW-TLVIYGFDRVSGGARWAILPFILT--IIVLMVTLLIIILRQPENPKKLP 615

  Fly   573 SVINVSPVICGMSLLMGVILFSGCAIHSWPGLLIWLMAGLILVIRCDKYCCNCFEHTTIMNAQLI 637
            .:....|.:...::|:.:.|....:..:|...::|...|:::......:           |:.|.
Zfish   616 YMAPCVPFVPTAAMLVNIYLMLKLSSITWVRFVVWCSLGVLIYFSYGMW-----------NSSLE 669

  Fly   638 PSVSGKSNMGSASGSASNLAGPSTSIRIPRPPKGMGVVGLPQRINEHRXQSESSEEEGEDLFH-- 700
            .|...::...|:..........|.::....||:        :...:.: |..::||.|   :|
Zfish   670 LSAREEAAHASSYQRYDTEVDDSFNVEEELPPE--------ENEEDGQYQGWAAEERG---YHYQ 723

  Fly   701 -------EDFNVRD-------FDEEDDED 715
                   :..|.|.       |:|.|:|:
Zfish   724 KQYQDEEQSHNYRSKGRTNKGFEELDNEE 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tadr	NP_724308.2	2A0303	5..>209	CDD:273330	55/231 (24%)
slc7a14b	XP_684639.2	2A0303	26..666	CDD:273330	148/710 (21%)
slc7a14b	XP_684639.2	AA_permease_C	616..666	CDD:290617	6/60 (10%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43243
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910