DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tadr and Slc7a14

DIOPT Version :9

Sequence 1:	NP_724308.2	Gene:	tadr / 35370	FlyBaseID:	FBgn0032911	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	NP_766449.1	Gene:	Slc7a14 / 241919	MGIID:	3040688	Length:	771	Species:	Mus musculus

Alignment Length:	700	Identity:	145/700 - (20%)
Similarity:	271/700 - (38%)	Gaps:	179/700 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LDVLCSGSGARLALGASVISYLIVYNEASAPSLLVGVVLATVYGAMAARC---------KTSLRS 62
            :|::..|.|:.:..|..|:|.|:. .|.:.|.::|..::|.|...::..|         ||:..:
Mouse    56 VDLISLGVGSCVGTGMYVVSGLVA-KEMAGPGVIVSFIIAAVASILSGVCYAEFGVRVPKTTGSA 119

  Fly    63 LQMPYVRATNKFDFSCLFLAIWLDALATVCACAALARTLSACLDAMTG-GLARILI--------L 118
            ....||...   :|...|:. |...|..:...||.|..||:..|::.. .::|.::        |
Mouse   120 YTYSYVTVG---EFVAFFIG-WNLILEYLIGTAAGASALSSMFDSLANHSISRWMVDTVGTLNGL 180

  Fly   119 GRNAPANEPWPDVLGVSVVFLVTGMFMLGLEHSRAFSLILTL------------GMFGLNAILSA 171
            |:   ..|.:||:|.:.:..:||.:..||:::|..|:.:|.:            |:|.:|.
Mouse   181 GK---GEESYPDLLALVIAVIVTIIVALGVKNSVGFNNVLNVLNLAVWVFIMIAGLFFING---- 238

  Fly   172 VGWWRGDMLAWSADSYFQPDGISSVFLGTALLTYSFPG-----------DWPQQLRGGRFTATLI 225
             .:|        |:..|.|.|.|.|..|.|...|:|.|           ..|........||:|:
Mouse   239 -KYW--------AEGQFLPHGWSGVLQGAATCFYAFIGFDIIATTGEEAKNPNTSIPYAITASLV 294

  Fly   226 ---TGLVSTSLLLTAICLSTVVHYRSQEDYVAVPLFNILDENGFH--KLVPASACMLLLTSSAAF 285
               |..||.|::||.:    |.:|....:   .||..:...:||:  |.|.|...:..||.| ..
Mouse   295 ICLTAYVSVSMILTLM----VPYYAIDTE---SPLMEMFVAHGFYAAKFVVAIGSVAGLTVS-LL 351

  Fly   286 LELFPELYGIVVRLATSEWRILSKQISYESSESGNPVLAVFIAGSMCAMLAFACPLQHLSYTLAA 350
            ..||| :..::..:|..  .:|.:.:::.||.:..||:|..::|.:.|:|:....|:.|...::.
Mouse   352 GSLFP-MPRVIYAMAGD--GLLFRFLAHVSSYTETPVVACIVSGFLAALLSLLVSLRDLIEMMSI 413

  Fly   351 GHMGGVFLRALYLLYIPYRP--------KYMA----PSSESSLSYSRLST-APFAKSSSYSSAAT 402
            |.:....|.::.:|.:.|:|        |:::    ...|..|:.....| :|.::...:||.||
Mouse   414 GTLLAYTLVSVCVLLLRYQPESDIDGFVKFLSEEHTKKKEGILADCEKETCSPVSEGEEFSSPAT 478

  Fly   403 SSSSRLKRSLWKIGLPKHSNLKKPKTKPRNKQELEKEWLLLGEPTSPCPQREGRDVESTILSDGE 467
            ::..                       .:|...|....:|:|:                    .:
Mouse   479 NTCG-----------------------AKNLPSLGDNEMLIGK--------------------SD 500

  Fly   468 PPPSDFEYPDKFDKSDSDTSTDIDAIVDEYREKIKVTTAGPLERSVRV----------PTVSSWR 522
            ....:..:|: :...|..|..:.|...:.|..|:| ...||...::|:          ||.::..
Mouse   501 KSAYNVNHPN-YGTVDMTTGIEADESENIYLIKLK-KLIGPRYYTMRIRLGLPGKMDRPTAATGH 563

  Fly   523 -VTIFAIVVIGLGIALC---------IAGLMMHWAPAALTGGIGVLIVTIMMGFI---------- 567
             |||..:::..|....|         |:| ...||         :|:|.:||..|
Mouse   564 TVTICVLLLFILMFIFCSFIIFGSEYISG-QSWWA---------ILLVVLMMLLISVLVFVILQQ 618

  Fly   568 ---PKYTGSVINVSPVICGMSLLMGVILFSGCAIHSWPGLLIWLMAGLIL 614
               ||....:....|.:...::|:.:.|....:..:|....:|...|:::
Mouse   619 PENPKKLPYMAPCLPFVPAFAMLVNIYLMLKLSTITWIRFAVWCFVGMLI 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tadr	NP_724308.2	2A0303	5..>209	CDD:273330	55/231 (24%)
Slc7a14	NP_766449.1	2A0303	43..677	CDD:273330	145/699 (21%)
Slc7a14	NP_766449.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	735..771
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3710
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43243
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.860