DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tadr and slc7a3b

DIOPT Version :9

Sequence 1:	NP_724308.2	Gene:	tadr / 35370	FlyBaseID:	FBgn0032911	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	XP_001342962.3	Gene:	slc7a3b / 100003376	ZFINID:	ZDB-GENE-120813-6	Length:	698	Species:	Danio rerio

Alignment Length:	707	Identity:	137/707 - (19%)
Similarity:	264/707 - (37%)	Gaps:	192/707 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LDVLCSGSGARLALGASVISYLIVYNEASAPSLLVGVVLATVYGAMAARCKTSLRSLQMPYVRAT 71
            ||::..|.||.|..|..|::..:. .|.:.|::::..::|.:...:|..|.... ..::|...:.
Zfish    87 LDLIALGVGATLGAGVYVLAGEVA-REKAGPAIVLSFLIAALSSVLAGLCYAEF-GARVPKTGSA 149

  Fly    72 NKFDFSCL-----FLAIWLDALATVCACAALARTLSACLDAMTGGLARILILGRNAPANEP---- 127
            ..:.:..:     |:..|...|:.|...|::||..||..|::   ||:.:.....|..:.|
Zfish   150 YVYSYVTVGEIWAFITGWNLILSYVIGTASVARAWSATFDSL---LAQKISTFFKAFMSFPDTQN 211

  Fly   128 ----WPDVLGVSVVFLVTGMFMLGLEHSRAFSLILTLGMFGLN-AILSAV---GWWRGDMLAW-- 182
                :|||..:.:|.|:||:...|:..|...:.|.|    |:| .:|:.|   |:.:||...|
Zfish   212 VLAKYPDVFALILVMLLTGLLAFGVSESALVNKIFT----GINLVVLTFVIISGFVKGDTANWNL 272

  Fly   183 SADSY--------------------FQPDGISSVFLGTALLTYSFPG---------DWPQQLRGG 218
            :.:.|                    |.|.|::.|..|.|...|:|.|         :....:|
Zfish   273 TVEDYINRTNITGAQKIEKEFGSGGFAPFGLNGVLSGAATCFYAFVGFDCIATTSEEAKNPMR-- 335

  Fly   219 RFTATLITGLVSTSLLL------TAICLSTVVHYRSQEDYVAVP-LFNILDENGFHKLVPASACM 276
                ::..|:|::.|:.      .:..|:.::.|...:.:..:| .|:.:.......:|...:..
Zfish   336 ----SIPIGIVASLLICFFAYFGVSAALTLMMPYYMLDKHSPLPQAFDYVGWGPARYIVSVGSLC 396

  Fly   277 LLLTSSAAFLELFPELYGIVVRLATSEWRILSKQISYESSESGNPVLAVFIAGSMCAMLAFACPL 341
            .|.||....:...|.     |..|.:|..:|.:.:|....::..|.||..::|.:.|::||...|
Zfish   397 ALSTSLLGSMFPMPR-----VIYAMAEDGLLFRFLSRMHKKTKTPALATLVSGIVAALMAFLFDL 456

  Fly   342 QHLSYTLAAGHMGGVFLRALYLLYIPYRPKYMAPSSESSLSYSRLSTAPFAKSSSYSSAATSSSS 406
            ..|...::.|.:....|.|:.:|.:.|:|             |||.          ||.|
Zfish   457 DALVDLMSIGTLLAYTLVAVCVLILRYQP-------------SRLG----------SSGA----- 493

  Fly   407 RLKRSLWKIGLPKHSNLKKPKTKPRNKQELEKEWLLLGEPTSPCPQREGRDVESTILSDGEPPPS 471
                                ..||...|.||.:.::              ||:|     |:
Zfish   494 --------------------DVKPVELQRLEAKAVM--------------DVDS-----GD---- 515

  Fly   472 DFEYPDKFDKSDSDTSTDIDAIVDEYREKIKVTTAGPLERSVRVPTVSSWRVTIFA-------IV 529
              ||           |.|::.|..:.|..|::.    ::....|||..|..:...|       ..
Zfish   516 --EY-----------SQDMETIPLKKRFSIRML----VQPICDVPTKISGIIVYSACGTISVLFT 563

  Fly   530 VIGLGIALCIAGLMM-HWAPAALTGGIGVL--IVTIMMGFIPKYTGSV---INVSPVICGMSLLM 588
            ::.|.:::|:..:.| |.....|...:.||  :..:::...|:...::   :.:.|::..:|:.:
Zfish   564 LLCLVLSVCLEQVAMGHPLFICLVVLLSVLSTVCIVVIWRQPQSKEALTFKVPLLPILPLISIFV 628

  Fly   589 GVILFSGCAIHSWPGLLIWLMAGLILVIRCDKYCCNCFEHTTIMNAQLIPSVSGKSN 645
            .:.|....:..:|....:|:..|.::      |......|          |..||:|
Zfish   629 NIYLMMQMSGATWIRFAVWMAIGFLI------YFAYGIRH----------SSEGKNN 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tadr	NP_724308.2	2A0303	5..>209	CDD:273330	56/240 (23%)
slc7a3b	XP_001342962.3	2A0303	57..665	CDD:273330	134/701 (19%)
slc7a3b	XP_001342962.3	AA_permease_C	613..663	CDD:290617	8/65 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810