DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG9265 and HSD17B12

DIOPT Version :10

Sequence 1:NP_610081.3 Gene:CG9265 / 35369 FlyBaseID:FBgn0032910 Length:399 Species:Drosophila melanogaster
Sequence 2:NP_057226.1 Gene:HSD17B12 / 51144 HGNCID:18646 Length:312 Species:Homo sapiens


Alignment Length:190 Identity:54/190 - (28%)
Similarity:98/190 - (51%) Gaps:14/190 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    89 ALITGGGNGLGRLLAERLGKMGTKVVIWDINKKGIAE-TVQIVEEAGGYCKGYVVDISKKEEVYK 152
            |::||..:|:|:..||.|.|.|.|||:...:|..:.: :.:|.|:.....:...||.: .|::| 
Human    53 AVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFA-SEDIY- 115

  Fly   153 AADVIRDEVG--DITLLINNAGVVSGL--HLLDTP--DHLIERSFNVNVMAHFWTTKAFLPKMIE 211
              |.|:..:.  :|.:|:||.|:....  :.||.|  |::|::..|:|:::....|:..||.|:|
Human   116 --DKIKTGLAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCKMTQLVLPGMVE 178

  Fly   212 NDRGHIATIASLAGHVGISKLVDYCASKFAAVGFDEALRLELEVLGHTNIRTTCICPFFI 271
            ..:|.|..|:|.:|.:.:..|..|.|:|.....|.:.|..|....|   :....:.|:|:
Human   179 RSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKG---VFVQSVLPYFV 235

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG9265NP_610081.3 17beta-HSDXI-like_SDR_c 88..328 CDD:187598 54/190 (28%)
HSD17B12NP_057226.1 17beta-HSD1_like_SDR_c 50..289 CDD:187614 54/190 (28%)
Di-lysine motif 308..312
Blue background indicates that the domain is not in the aligned region.

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