Protein Alignment CG9265 and HSD17B3

DIOPT Version :10

• Sequence 1: NP_610081.3
• Gene: CG9265 / 35369
• FlyBaseID: FBgn0032910
• Length: 399
• Species: Drosophila melanogaster
• Sequence 2: NP_000188.1
• Gene: HSD17B3 / 3293
• HGNCID: 5212
• Length: 310
• Species: Homo sapiens
• Alignment Length: 274
• Identity: 65/274 - (23%)
• Similarity: 115/274 - (41%)
• Gaps: 54/274 - (19%)

  Fly    89 ALITGGGNGLGRLLAERLGKMGTKVVIWDINKKGIAETVQIVE--------EAGGYCKGYVVDIS 145
            |:|||.|:|:|:..:..|.|.|..||:       |:.|::.:|        ..|...|....|.:
Human    51 AVITGAGDGIGKAYSFELAKRGLNVVL-------ISRTLEKLEAIATEIERTTGRSVKIIQADFT 108

  Fly   146 KKEEVYKAADVIRDEVG--DITLLINNAGVVSGL---HLLDTPDHLIERSFNVNVMAHFWTTKAF 205
             |:::|   :.|::::.  :|.:|:||.|::..|   |.|:.||. |:...:.|:.:....|:..
Human   109 -KDDIY---EHIKEKLAGLEIGILVNNVGMLPNLLPSHFLNAPDE-IQSLIHCNITSVVKMTQLI 168

  Fly   206 LPKMIENDRGHIATIASLAGHVGISKL-----VDYCASKFAAVGFDEALRLELEVLGHTNIRTTC 265
            |..|....:|.|..|:|     ||:..     ..|.|||.....|.:||:.|.:.   ..:....
Human   169 LKHMESRQKGLILNISS-----GIALFPWPLYSMYSASKAFVCAFSKALQEEYKA---KEVIIQV 225

  Fly   266 ICPFFIQATGMFDDVNARWVPTLNPNDVADRVIAAIRKNEKLAVIPGFL------KVLLSFKWTF 324
            :.|:.: :|.|        ...||.|.:.......::::.....|.|..      ::|..|....
Human   226 LTPYAV-STAM--------TKYLNTNVITKTADEFVKESLNYVTIGGETCGCLAHEILAGFLSLI 281

  Fly   325 P-WGCVGGLLKRLV 337
            | |....|..:||:
Human   282 PAWAFYSGAFQRLL 295

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9265	NP_610081.3	17beta-HSDXI-like_SDR_c	88..328	CDD:187598	62/263 (24%)
HSD17B3	NP_000188.1	17beta-HSD1_like_SDR_c	48..284	CDD:187614	61/261 (23%)