DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Itgbn and itgb7

DIOPT Version :9

Sequence 1:	NP_001303333.1	Gene:	Itgbn / 35368	FlyBaseID:	FBgn0010395	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	XP_001337949.3	Gene:	itgb7 / 797491	ZFINID:	ZDB-GENE-100728-2	Length:	755	Species:	Danio rerio

Alignment Length:	781	Identity:	236/781 - (30%)
Similarity:	376/781 - (48%)	Gaps:	106/781 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 CRHADSCERCLSAHLECAWCTDKEYQVG-----YRCLSRRQLLNYNCSETDIYE-NQPVLDVLQD 91
            |::..||..|:.:. .|||||...:...     .||.|.:.|.:..|.:..:.. .:..||.:::
Zfish    28 CQNQPSCSECIRSP-GCAWCTQMNFLKSGESNERRCDSPKSLKDRGCEDVRVINPGKHPLDYVKN 91

  Fly    92 KPLKDYETSDQAVQVTPQRAYLKLVKGNTQRMKLSYRTARNNPLDLYVLMDLTWTMRDDKKTLEE 156
            ..|.:  .|...||:.||...:||..|......:.::.|:..|:|||.||||:::|:||.:.::.
Zfish    92 NDLSN--DSYNVVQLKPQNVNIKLRVGVPYEFTVEFKRAQGYPIDLYYLMDLSYSMQDDLEQIKT 154

  Fly   157 LGAQLSQTLKNLTGNYRLGFGSFADKPTLPMI--LPQHRENPCAAERATCEPTYGYRHQLSLTDD 219
            ||.::.:.||::|...|:|||||.||..||.:  ||..|:|||.....||:..:.:::.|.||.|
Zfish   155 LGQKILKKLKDITETVRIGFGSFVDKEMLPYVSQLPPRRKNPCPNRINTCQKAFMFQNVLPLTSD 219

  Fly   220 IPAFTSAVANSKITGNLDNLEGGLDALMQVIVCTKEIGWKEQARKVVILVTDGFMHLAGDGLLAG 284
            ...|...|:...|:||||:.|.||||:||..||..:|.|....| :::..:|...|:||||.|.|
Zfish   220 GREFEREVSKQNISGNLDSPEAGLDAIMQAAVCKDKIKWGNVTR-ILVYTSDDTFHMAGDGRLGG 283

  Fly   285 IIQRNDKQCHLNKAGEYTGSLNYDYPSLEEIYRELLRRKINVIFAVTEEVVSSYWELSALMKEIS 349
            ....::.|||.|..|.|.|.. |||||:..:.|.|....|.:|||||||:..:|..||||:.: |
Zfish   284 AFLPHNGQCHFNDMGSYIGKA-YDYPSVGHVSRVLQDNNIQLIFAVTEEIYPAYKALSALIPQ-S 346

  Fly   350 YVDILSADSSNILELIKKSYESLIKRTQF-ADNSPDFIDMAYYTDCGGQFPS--LQKRNYCNNVT 411
            .|.:|..||||:::||.::|.:|...... .:.:|..:.::|.:.|.....:  .:::..|..:.
Zfish   347 VVGVLKKDSSNVVDLISEAYGNLSSTLVLEQEGAPAELMVSYRSKCKDNQAANEWREKGECQGIK 411

  Fly   412 LGK---QIDFYVDVTLKKYPDNQVYTHKIRVEETSLSEFMDLDVELQRPCPCQETPDPENEEGRF 473
            ..|   |:.......||   :.|::    |::...:||.:.:.|:.:..|.|...     |:...
Zfish   412 HEKITFQVRLNATACLK---EPQIF----RIKMQGISEEVKITVDTECQCDCGAA-----EKSSE 464

  Fly   474 LCDYKGYLYCGMCECDEGWTGTYCNCPTDATNVTSNEA--LLQKCRQPFSDKSTSELVCSNHGDC 536
            .|::||.|.||||.||||:.|..|:|      |..|:.  :|..||     .:...||||..|.|
Zfish   465 HCNHKGDLSCGMCSCDEGYLGQNCSC------VQQNDTIKMLDSCR-----PNNRSLVCSGQGSC 518

  Fly   537 DCGTCLCDPGYTGPFCEC-------RECLDCDEKLADCFCGQCVCKYGWSGSKCNCDGDTDACVG 594
            :||.|:|...|:|.:|||       |..:.|:.| ..|.||:|.|:..::||.|.|....|.|..
Zfish   519 ECGNCVCRNEYSGKYCECDPDSCEKRNGVRCNGK-GKCECGKCECRDRYTGSACECSPSQDKCKN 582

  Fly   595 PTGEICSERGTCQCEECQCEEPYLGKFCEIDPEKDNKLCLFYEPCVTCLIEQKQGMGVCENLTEI 659
            ..| :||.:|.|.|..|.|:...:|.:|....:    .|..::.|:.|.:|   |.|.|
Zfish   583 DWG-LCSGQGECVCNRCHCKPGVIGDYCSAFMD----ACELFKDCLACHLE---GSGSC------ 633

  Fly   660 CSSLDRQETYPYNFVHELDPEQDQC----LVRLVNKHGIQCDSFFVYQVIDHSNFLTIQA-VDCE 719
                           ||      :|    :..|...|.:.|    :|:.:.:|..|.... |:.:
Zfish   634 ---------------HE------RCFNATVKHLEGTHELSC----IYKHVSYSVELKASGEVNVK 673

  Fly   720 PPDY-------VALVGYISAFTLLIGLLIIFIILWYIRAKDAREYAKFEEDQKNSVRQE--NPIY 775
            ..|.       ..::|...:..::.|::||.|....:...|.|||..|.:.|..:..:|  ||::
Zfish   674 YADLPHTVDKTAVIIGSSVSGIIITGIIIIIIYRLLLELYDYREYQSFVKMQNQTQWKEAQNPLF 738

  Fly   776 R 776
            :
Zfish   739 K 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Itgbn	NP_001303333.1	INB	38..460	CDD:197563	142/435 (33%)
		EGF_2	524..552	CDD:285248	12/27 (44%)
		Integrin_b_cyt	748..785	CDD:285884	9/31 (29%)
itgb7	XP_001337949.3	vWFA	33..454	CDD:320736	141/433 (33%)
itgb7	XP_001337949.3	Integrin_b_cyt	709..750	CDD:312304	9/31 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1226
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100678
Panther	1	1.100	-	-	O	PTHR10082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.780