DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Itgbn and itgb3a

DIOPT Version :9

Sequence 1:	NP_001303333.1	Gene:	Itgbn / 35368	FlyBaseID:	FBgn0010395	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	NP_001032312.1	Gene:	itgb3a / 564266	ZFINID:	ZDB-GENE-071207-1	Length:	785	Species:	Danio rerio

Alignment Length:	820	Identity:	255/820 - (31%)
Similarity:	382/820 - (46%)	Gaps:	109/820 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LWIYLVFLIAEISHSDADSIDDQC--RHADSCERCLSAHLECAWCTDKEYQVGYRCLSRRQL--- 69
            :|:.::.||:....|:.      |  |...:|:.|||.|..||||:.:.:|.|...|||..|
Zfish     8 VWMPVLLLISIAKGSNI------CTSRGVSTCKECLSIHPTCAWCSQEVFQKGGSALSRCDLKDN 66

  Fly    70 ----------LNYNCSETDIYENQPVLDVLQDKPLKDYETSDQAVQVTPQRAYLKLVKGNTQRMK 124
                      :.:..|...|.||.|:.|       |...:.....|:.||:..|.|...::::..
Zfish    67 IIQSGCSGKFIEFPVSSVKIVENIPLSD-------KAGGSGSDITQIQPQKIQLTLRPDDSRKFT 124

  Fly   125 LSYRTARNNPLDLYVLMDLTWTMRDDKKTLEELGAQLSQTLKNLTGNYRLGFGSFADKPTLPMIL 189
            ::.:...:.|:|||.|||:|.|||.:.:||..||..|:..|:.:|.|.|:|||:|.||...|.:.
Zfish   125 VTVKQVADYPVDLYYLMDMTNTMRKNLQTLYTLGNNLAGALRGVTSNLRMGFGAFVDKTVSPYMY 189

  Fly   190 ---PQHRENPCAAERATCEPTYGYRHQLSLTDDIPAFTSAVANSKITGNLDNLEGGLDALMQVIV 251
               |:...|||......|.|.:|||:.||||:.:..||..|...|::.|.|:.|||.||:.|.:|
Zfish   190 TYPPEVITNPCYKTSEFCPPQFGYRNVLSLTEQVERFTEEVKKQKVSRNRDSPEGGFDAIFQAVV 254

  Fly   252 CTKEIGWKEQARKVVILVTDGFMHLAGDGLLAGIIQRNDKQCHLNKAGEYTGSLNYDYPSLEEIY 316
            |..:|||:..|..:::..||...|.|.|..|:||:|.:|.:||:|...||..:...||||:..|.
Zfish   255 CKDKIGWRSDASHLLVFTTDDISHSALDARLSGIVQPHDGECHINDQNEYDKTTILDYPSVGTIT 319

  Fly   317 RELLRRKINVIFAVTEEVVSSYWELSALMKEISYVDILSADSSNILELIKKSYESLIKRTQF-AD 380
            .::....||:|||||..|...|...|.|:.. |.|..|:.||||:::||.:.|..:..:.:. ..
Zfish   320 DKISENNINLIFAVTSNVAPLYRNYSELIPG-STVGTLTKDSSNVVQLILELYAKIRSKVELELL 383

  Fly   381 NSPDFIDMAYYTDC--GGQFPSLQKRNYCNNVTLGKQIDFYVDVTLKKYP--DNQVYTHKIRVEE 441
            |.||.:.::....|  ....|.::.   |:.:.:|..:.|.::..|...|  .:|.:|    |:.
Zfish   384 NVPDELSLSVTATCLDDEVIPGVRS---CDGLKIGDMVSFSIEAKLHGCPKQKSQTFT----VKP 441

  Fly   442 TSLSEFMDLDVELQRPCPCQETPDPEN---EEGRFLCDYKGYLYCGMCECDEGWTGTYCNCPTDA 503
            ....:.:.:.|:....|.||:...|.:   .||      .|.|.||.|.||.|..|:.|.|
Zfish   442 IGFKDALQVTVDFACDCTCQQNSVPASPYCHEG------NGTLECGTCLCDPGRLGSRCEC---- 496

  Fly   504 TNVTSNEALLQKCRQPFSDKSTSELVCSNHGDCDCGTCLCDPG----YTGPFCECRE--CLDCDE 562
                 :|:..:..:|.....|.....||..|||.||.|.|...    ..||||||.:  |.....
Zfish   497 -----SESEYKPTQQDSCSPSPEARTCSGRGDCVCGQCACRSSNFGKVWGPFCECDDFSCPRSKG 556

  Fly   563 KL----ADCFCGQCVCKYGWSGSKCNCDGDTDACVGPTGEICSERGTCQCEECQCEEP-YLGKFC 622
            :|    .:||||.|.|..||||..|:|...||.|:|..|.:||.||.|.|..|.|.:| ..|..|
Zfish   557 QLCSGNGECFCGSCHCGSGWSGESCDCSTRTDTCMGSGGLMCSGRGHCVCGVCNCTQPGAYGSTC 621

  Fly   623 EIDPEKDNKLCLFYEPCVTCLIEQKQGMGVCE-NLTEIC-------SSLDRQETYPYNFVHELDP 679
            :..|...: .|...:.||.|. ..|:|.|:.| |...:|       ..|...||...|..::
Zfish   622 DKCPTCPD-ACTIKKECVECK-HYKRGGGLFEKNCNHVCRDEIVLVEELGFFETNAVNCSYK--- 681

  Fly   680 EQDQCLVRLVNKHGIQCDSFFVYQVIDHSNFL-TIQAVDCEPPDYV-----ALVGYISAFTLLIG 738
            ::|.|:           .:|..|:.....:.| .::..||.....|     |:||.|    ||:|
Zfish   682 DEDDCV-----------QNFQYYEDASGKSLLYLVKEPDCPKGADVLVVALAVVGAI----LLLG 731

  Fly   739 LLIIFIILWYIRAKDAREYAKFEEDQKNSVRQ--ENPIYR 776
            |..:.|....|...|.||:|||||::..:..:  .||:|:
Zfish   732 LAALLIWKLLITIHDRREFAKFEEEKAKAKWEAANNPLYK 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Itgbn	NP_001303333.1	INB	38..460	CDD:197563	141/442 (32%)
		EGF_2	524..552	CDD:285248	12/31 (39%)
		Integrin_b_cyt	748..785	CDD:285884	12/31 (39%)
itgb3a	NP_001032312.1	Integrin_beta	32..458	CDD:278776	140/440 (32%)
		Integrin_B_tail	631..714	CDD:285239	21/97 (22%)
		Integrin_b_cyt	741..783	CDD:285884	12/31 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596172
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1226
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100678
Panther	1	1.100	-	-	O	PTHR10082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.750