DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Itgbn and itgb5

DIOPT Version :9

Sequence 1:	NP_001303333.1	Gene:	Itgbn / 35368	FlyBaseID:	FBgn0010395	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	NP_001076305.1	Gene:	itgb5 / 563556	ZFINID:	ZDB-GENE-030131-6022	Length:	823	Species:	Danio rerio

Alignment Length:	789	Identity:	251/789 - (31%)
Similarity:	379/789 - (48%)	Gaps:	87/789 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 ADSCERCLSAHLECAWCTDKEY----QVGYRCLSRRQLLNYNCSETDIYENQPVLDVLQDKPLKD 96
            |.|||.||..|..||||..:::    .:..||...:.|....|....|...:....|||.||| .
Zfish    58 ATSCEECLLIHPSCAWCAQEDFGQARTLTSRCDFSQNLQKRGCDAPFIENPRSGSSVLQSKPL-S 121

  Fly    97 YE----TSDQAVQVTPQRAYLKLVKGNTQRMKLSYRTARNNPLDLYVLMDLTWTMRDDKKTLEEL 157
            |:    |....:|:.||:..|.|..|:....::..|...:.|:|||.||||:.:|:||..|:..|
Zfish   122 YKGSGVTQYDVIQIYPQKISLSLRPGDQASFEVQVRPVEDYPVDLYYLMDLSLSMKDDLDTIRNL 186

  Fly   158 GAQLSQTLKNLTGNYRLGFGSFADKPTLPM--ILPQHRENPCAAER--ATCEPTYGYRHQLSLTD 218
            |.:|::.::.||.|:|||||||.||...|.  ...::::|||...:  ..|.||:|:||.|||||
Zfish   187 GTKLAEEMRKLTSNFRLGFGSFVDKNISPFSYTASKYQDNPCNGYKLFPNCVPTFGFRHLLSLTD 251

  Fly   219 DIPAFTSAVANSKITGNLDNLEGGLDALMQVIVCTKEIGWKEQARKVVILVTDGFMHLAGDGLLA 283
            .:..|...|....::.|.|..|||.||::|..||.::|||:::|..:::..||...|||.||.|.
Zfish   252 KVDRFNEEVQKQMVSRNRDAPEGGFDAILQAAVCREKIGWRKEAYHLLVFATDDVPHLALDGKLG 316

  Fly   284 GIIQRNDKQCHLNKAGEYTGSLNYDYPSLEEIYRELLRRKINVIFAVTEEVVSSYWELSALMKEI 348
            |::..:|.|||||...||:.|...|||||..:..:|....|.:||||.:.....|..|:||:...
Zfish   317 GLVHPHDGQCHLNDKNEYSASTKMDYPSLALLGEKLAENNIFLIFAVIKRHYVLYKNLTALIPGT 381

  Fly   349 SYVDILSADSSNILELIKKSYESLIKRTQFAD-NSPDFIDMAYYTDC--GGQFPSLQKRNYCNNV 410
            : |:||..||.||::||..:|.::..:.:.:. :.|:.:.:|:...|  |.....|:|   |.::
Zfish   382 T-VEILDQDSKNIIQLIVNAYNNIRSKVELSVWDHPEDLSLAFSATCQDGQPLTGLRK---CADL 442

  Fly   411 TLGKQIDFYVDVTLKKYPDNQVYTHK-IRVEETSLSEFMDLDVELQRPCPCQETPDPENEEGRFL 474
            .:|..:.|.|.|..:..|...  |.| ..:......:.:::.|:.:..|.|.....|.:..
Zfish   443 KIGDTVSFNVTVDARGCPPKG--TRKSFTIRPVGFKDRLEVSVDYRCDCRCTYHTKPNSSR---- 501

  Fly   475 CDYKGYLYCGMCECDEGWTGTYCNCPTDATNVTSNEALLQKCRQPFSDKSTSELVCSNHGDCDCG 539
            |:..|...||:|.|:.|:.|..|.|.....    :...|..||:     :..:.|||..|:|.|.
Zfish   502 CNSAGTYNCGLCRCEPGYLGARCECQEGEV----DHQHLSACRE-----AEGKQVCSGRGECSCN 557

  Fly   540 TCLCDPGYT-------GPFCECRECLDCDEKL-------ADCFCGQCVCKYGWSGSKCNCDGDTD 590
            .|||   |.       |.||||.: ..|....       .:|.||:|.|..|:.|..|||..:|.
Zfish   558 QCLC---YESEFGKIYGTFCECDD-FSCARHKGILCSGHGECHCGECKCHAGYIGDNCNCSTETA 618

  Fly   591 ACVGPTGEICSERGTCQCEECQCEEP-YLGKFCEIDPEKDNKLCLFYEPCVTCLIEQKQGMGVCE 654
            :||...|:|||.||:|.|..|||.|| ..|..||..|...: .|.....|:.|.:.....:  .:
Zfish   619 SCVSDDGKICSGRGSCVCGRCQCTEPGAFGDTCEKCPTCPD-ACGTKRECIECRLFNTGRL--AD 680

  Fly   655 NLTEICSSLDRQETYPYNFVHELDPEQDQCLVRLVNKHGIQCDSFFVYQVIDHSNFLTIQAVDCE 719
            |.|  |..:.:.|......:...||...||:.:..|    .|...|.|.  :|:|..::.....|
Zfish   681 NQT--CQRMCKDEITTVETLKTDDPNAVQCVYKTEN----DCVMKFTYS--EHANGQSVLTALKE 737

  Fly   720 P-----PD----YVALVGYISAFTLLIGLLIIFIILW--YIRAKDAREYAKFEEDQKNSVRQE-- 771
            |     |:    .:|:||.|    ||:|  |:.:.||  .|...|.||:|:| :..::..|.|
Zfish   738 PECAVAPNAMTVLLAVVGSI----LLMG--IVLLALWKLVITVHDRREFARF-QSARSRARYEMA 795

  Fly   772 -NPIYRDPV 779
             ||:|:..|
Zfish   796 SNPVYKRSV 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Itgbn	NP_001303333.1	INB	38..460	CDD:197563	147/437 (34%)
		EGF_2	524..552	CDD:285248	11/34 (32%)
		Integrin_b_cyt	748..785	CDD:285884	12/35 (34%)
itgb5	NP_001076305.1	Integrin_beta	60..489	CDD:278776	146/435 (34%)
		Integrin_B_tail	661..744	CDD:285239	19/92 (21%)
		Integrin_b_cyt	771..>804	CDD:285884	11/33 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596169
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1226
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100678
Panther	1	1.100	-	-	O	PTHR10082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.750