Protein Alignment Itgbn and itgb8

DIOPT Version :10

• Sequence 1: NP_523608.2
• Gene: Itgbn / 35368
• FlyBaseID: FBgn0010395
• Length: 799
• Species: Drosophila melanogaster
• Sequence 2: XP_073787461.1
• Gene: itgb8 / 556752
• ZFINID: ZDB-GENE-071213-3
• Length: 779
• Species: Danio rerio
• Alignment Length: 812
• Identity: 226/812 - (27%)
• Similarity: 356/812 - (43%)
• Gaps: 140/812 - (17%)

  Fly     7 RAFLWIYLVFLIAEISHSDADSIDDQCRHA--DSCERCLSAHLECAWCTDKEY----QVGYRCLS 65
            |..|.:..|.|:...|    :|.|::|..|  .:||.||....|||||:.:.:    .|..||.|
Zfish    15 RMLLLLISVLLLLVRS----NSADNRCLSALISTCEDCLRRGPECAWCSQERFLDGAHVSQRCGS 75

  Fly    66 RRQLLNYNCSETDIYENQPVLDVLQDKPLKDYETSDQAVQVTPQRAYLKLVKGNTQRMKLSYRTA 130
            ...|....|.| :..|| |.:.|       :...:..:.||.|:...:.|..|:.....:..:..
Zfish    76 VSDLRVRGCEE-EFIEN-PKVKV-------EVNATISSSQVAPREITIHLRPGSEASFVIEVQQL 131

  Fly   131 RNNPLDLYVLMDLTWTMRDDKKTLEELGAQLSQTLKNLTGNYRLGFGSFADKPTLPMI--LPQHR 193
            ...|:|||.|:|::.:|:|:...|:.:|..||..:|..:.::|:|||||.|||..|.|  .|...
Zfish   132 ERYPVDLYYLVDVSASMQDNLDRLKTVGLALSHQMKQHSSDFRVGFGSFVDKPVSPYIDVHPSKL 196

  Fly   194 ENPCAAERATCEPTYGYRHQLSLTDDIPAFTSAVANSKITGNLDNLEGGLDALMQVIVCTKEIGW 258
            .|||:.....|.|.:|:.|.|.:|.::..||..:...:|:||:|..|||.||::|..||.|:|||
Zfish   197 LNPCSEYEVHCRPAHGFIHVLPVTQNMSEFTRVIQEQRISGNMDTPEGGFDAMLQATVCQKDIGW 261

  Fly   259 KEQARKVVILVTDGFMHLAGDGLLAGIIQRNDKQCHLNKAGEYTGSLNYDYPSLEEIYRELLRRK 323
            :.:|:.:::::||...|||.|..||||:..:|.:||| :...|:.:...::|::.::..:||...
Zfish   262 RPEAKHLLLVMTDQPSHLALDSKLAGIVVPHDGRCHL-EDNVYSQTSTMEHPTVAQLAEKLLENS 325

  Fly   324 INVIFAVTEEVVSSYWELSALMKEISYVDILSADSSNILELIKKSYESLIK--RTQFADNSPDFI 386
            |..||||.......|.:|..|:.. |||..|...:||:.:|:.::|:.|:.  ..|.....|...
Zfish   326 IYSIFAVDHLQYQWYEDLVDLIPG-SYVGRLFPKASNLKDLVVQAYKKLLSDVEVQMELQDPQQA 389

  Fly   387 DMAYYTDCGGQFP---SLQKRNYCNNVTLGKQIDFYVDVTLKKYPDNQVYTHKIRVEETSLSEFM 448
            : .::.:.....|   |....:.|:.|...:.:.|.:.|.:...|....
Zfish   390 E-RFWVNVSAICPGGSSAAGNSKCSGVQPKQTVFFQLTVGMLSCPAGSA---------------- 437

  Fly   449 DLDV-ELQRPCPCQETPDPENEEGRFLCDYKGYLYCGMCECDEGWTGTYCNCP-TDATNVTSNEA 511
            |.|| .|.||....|:   .....|.||                  |:.|..| .:.::.|:|.:
Zfish   438 DQDVLMLVRPVGFNES---VRVRIRQLC------------------GSGCTDPKPEPSSCTTNAS 481

  Fly   512 LLQKCRQPFSDKSTSELVCSNHGDCDCGTCLCDP----GYTGPFCECRECLDC--DEKL-----A 565
              ..||:   .::|.  |||:.|.|.||||:||.    ...|.|||..: ..|  |..|     .
Zfish   482 --DSCRE---HRNTP--VCSSRGVCRCGTCVCDSSRFGNIYGKFCEMDD-FSCPYDGGLVCGGHG 538

  Fly   566 DCFCGQCVCKYGWSGSKCNCDGDTDACVGPTGEICSERGTCQCEECQCEEP-YLGKFCEIDPEKD 629
            .|..|:|||..||:|..|.|...||:||...|.||.:||.|.|.:|.|::| ..|.|||..| ..
Zfish   539 RCVRGECVCFSGWTGEACACRESTDSCVSDDGFICGDRGRCVCGKCVCDDPRRSGAFCEKCP-MC 602

  Fly   630 NKLCLFYEPCVTCLIEQKQGMGVCENLTEICSSLDRQETYPYNFVHE----------LDPEQDQC 684
            :..|..:..||.|.:....|....:...:.||.|       .::|.:          |.|..|:|
Zfish   603 HSSCQSHWNCVNCHLSNGLGSDGFQLCNQSCSPL-------VDYVDDITELVRGKYCLYPSTDKC 660

  Fly   685 LVRL------------VNKHGIQCDSFFVYQVIDHSNFLTIQAVDCEPPDYVALVGYISAFTLLI 737
            ..|.            :::|.: |       |.....|.|..:|            ::...||.|
Zfish   661 QYRFLMELASDGAQLHISRHPV-C-------VWSRRYFKTFLSV------------FLLTVTLGI 705

  Fly   738 GLLIIFIILWYIRAKD--AREYAKFEEDQKNS 767
            |:|.....|..:..:.  ::...:||...|:|
Zfish   706 GMLAGVRQLLRVTGRSCISKTEPQFEHTHKDS 737

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Itgbn	NP_523608.2	INB	38..460	CDD:197563	128/433 (30%)
		EGF_2	529..552	CDD:400365	12/26 (46%)
		Integrin_b_cyt	752..785	CDD:462580	4/18 (22%)
itgb8	XP_073787461.1	None