DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Itgbn and itgb1a

DIOPT Version :9

Sequence 1:	NP_001303333.1	Gene:	Itgbn / 35368	FlyBaseID:	FBgn0010395	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	XP_017209323.1	Gene:	itgb1a / 556734	ZFINID:	ZDB-GENE-060803-2	Length:	802	Species:	Danio rerio

Alignment Length:	822	Identity:	264/822 - (32%)
Similarity:	416/822 - (50%)	Gaps:	82/822 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IYLVFLIAEISHSDADSIDDQCRHAD--SCERCLSAHLECAWCTDKEY-----QVGYRCLSRRQL 69
            :::..|:..||.|.|....::|..|:  ||..|:....:|.||||.|:     ....||.....|
Zfish     6 LFISALLGIISCSHAQQEGNECIKANALSCGECIQVGDKCGWCTDAEFLKQGEPTSARCDELESL 70

  Fly    70 LNYNCSETDIYENQPVLDVLQDKPLKDYETS------DQAVQVTPQRAYLKLVKGNTQRMKLSYR 128
            ....|:|..|........:|::.|:.:.:..      :...|:.||:..|:|..|..|.:||.::
Zfish    71 KKRGCAEDKIENPHGSQRILKNTPVTNRKKGAEKLRPEDITQIQPQKLSLQLRSGEPQNIKLKFK 135

  Fly   129 TARNNPLDLYVLMDLTWTMRDDKKTLEELGAQLSQTLKNLTGNYRLGFGSFADKPTLPMI--LPQ 191
            .|.:.|:|||.||||:::|:||.:.::.||..|.:.:..:|.::|:|||||.:|..:|.|  .|.
Zfish   136 RAEDYPIDLYYLMDLSYSMKDDLENVKNLGTSLMKEMSKITSDFRIGFGSFVEKTVMPYISTTPA 200

  Fly   192 HRENPCAAERATCEPTYGYRHQLSLTDDIPAFTSAVANSKITGNLDNLEGGLDALMQVIVCTKEI 256
            ...|||..:: .|...:.|::.|.||.:...|.|.|...:|:||||:.|||.||:|||.||.:.|
Zfish   201 KLLNPCTGDQ-NCTSPFSYKNVLKLTSNGQRFNSLVGQQQISGNLDSPEGGFDAIMQVAVCGEHI 264

  Fly   257 GWKEQARKVVILVTDGFMHLAGDGLLAGIIQRNDKQCHLNKAGEYTGSLNYDYPSLEEIYRELLR 321
            ||:...| :::..||...|.||||.|.||:..||.:|||.. ..||.|..|||||:..:.::|..
Zfish   265 GWRNVTR-LLVFSTDAGFHFAGDGKLGGIVLPNDGRCHLEN-DMYTMSHYYDYPSIAHLVQKLSE 327

  Fly   322 RKINVIFAVTEEVVSSYWELSALMKEISYVDILSADSSNILELIKKSYESLIKRTQFADNS--PD 384
            ..|..|||||||....|.||..|:.: |.|..|||:|||::.||..:|.||.... ..:||  |:
Zfish   328 NNIQTIFAVTEEFQPVYKELKNLIPK-SAVGTLSANSSNVINLIVDAYNSLSSEV-ILENSKLPE 390

  Fly   385 FIDMAYYTDC-GGQFPSLQKRNYCNNVTLGKQIDFYVDVTLKKYPDNQVYTHKIRVEETSLSEFM 448
            .:.:.|.:.| .|.....:....|:|:::|.::.|.:::|.:..| .|..|..|:::....:|.:
Zfish   391 GVTITYQSRCKNGVVNEGESGRKCSNISIGDEVSFNINITAQGCP-KQGKTETIKIKPLGFTEEV 454

  Fly   449 DLDVELQRPCPC-----QETPDPENEEGRFLCDYKGYLYCGMCECDEGWTGTYCNCPTDATNVTS 508
            ::.:.....|.|     :.:|...|..|.|        .||.|.|::|..|..|.|..|.   .|
Zfish   455 EITLSFICECECHKHAMKNSPLCHNGNGSF--------ECGACRCNKGRVGRQCECRKDE---VS 508

  Fly   509 NEALLQKCRQPFSDKSTSELVCSNHGDCDCGTCLC------DPGYTGPFCECRECLDCD---EKL 564
            .|.|.:.||:   |..|.  :|||:|:|.||||.|      :..|:|.:||| :..:||   .||
Zfish   509 TEDLDKNCRK---DNGTD--ICSNNGECVCGTCECKKRENPEERYSGKYCEC-DNFNCDRSNNKL 567

  Fly   565 AD----CFCGQCVCKYGWSGSKCNCDGDTDACVGPTGEICSERGTCQCEECQCEEP-YLGKFCEI 624
            ..    |.|..|||...::||.|:|..||..|:....:||:.||.|:|..|:|.:| :.|..|||
Zfish   568 CGGHGRCECRVCVCDANYTGSACDCSLDTSTCLASNKQICNGRGICECGTCRCTDPKFQGPTCEI 632

  Fly   625 DPEKDNKLCLFYEPCVTCLIEQKQGMGVCENLTEICSSLDRQETYPYNFVHELD------PEQDQ 683
            .|.... :|..::.||.|     :..|..|. .:.|.   |..:| :|.:...|      |.|..
Zfish   633 CPTCPG-VCTEHKECVQC-----RAFGTGEK-KDTCK---RDCSY-FNLIEVEDRDKLPQPVQAF 686

  Fly   684 CLVRLVNKHGIQCDSFFVYQVIDHS--NFLTIQAVDCEP-PDYVALVGYISAFTLLIGLLIIFII 745
            .|:....:....|..::.|.|.:::  ....::.::|.| ||.:.:|..:.|..:||||.::.|.
Zfish   687 PLMHCKERDARDCWFYYTYAVNNNTEKEVHVVKTMECPPGPDIIPIVAGVVAGIVLIGLALLLIW 751

  Fly   746 LWYIRAKDAREYAKFEEDQKNSV--RQENPIYRDPVGRYEVP 785
            ...:...|.||:||||:::.|:.  ..|||||:.|:.:::.|
Zfish   752 KLLMIIHDRREFAKFEKEKMNAKWDTTENPIYKSPINKFQNP 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Itgbn	NP_001303333.1	INB	38..460	CDD:197563	148/437 (34%)
		EGF_2	524..552	CDD:285248	13/33 (39%)
		Integrin_b_cyt	748..785	CDD:285884	14/38 (37%)
itgb1a	XP_017209323.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1226
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100678
Panther	1	1.100	-	-	O	PTHR10082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.780