DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Itgbn and mys

DIOPT Version :9

Sequence 1:	NP_001303333.1	Gene:	Itgbn / 35368	FlyBaseID:	FBgn0010395	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	NP_001284997.1	Gene:	mys / 44885	FlyBaseID:	FBgn0004657	Length:	846	Species:	Drosophila melanogaster

Alignment Length:	877	Identity:	272/877 - (31%)
Similarity:	410/877 - (46%)	Gaps:	141/877 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 RAFLWIYLVFLIAEIS-HSDAD-----SIDDQCRHADSCERCLSAHLECAWCTDKEYQVGYRCLS 65
            |..|.:.::.::|.|: .:||.     :....|...:.|..|:... .||||...:::...||..
  Fly     8 RCQLALLMIAILAAIAGQTDAQKAAKLTAVSTCASKEKCHTCIQTE-GCAWCMQPDFKGQSRCYQ 71

  Fly    66 RRQLLNYNCSETDIYENQPVLDVLQDKPLKD---------------------------------- 96
            ....|   |.|...|....|..:|.:..|.:
  Fly    72 NTSSL---CPEEFAYSPITVEQILVNNKLTNQYKAELAAGGGGSAMSGSSSSSYSSSSSSSSFYS 133

  Fly    97 -----------YE--TSDQAVQVTPQRAYLKLVKGNTQRMKLSYRTARNNPLDLYVLMDLTWTMR 148
                       ||  ::.:.||:.||...|.|.......:|:||..|...|:|||.||||:.:|.
  Fly   134 QSSSGSSSASGYEEYSAGEIVQIQPQSMRLALRVNEKHNIKISYSQAEGYPVDLYYLMDLSKSME 198

  Fly   149 DDKKTLEELGAQLSQTLKNLTGNYRLGFGSFADKPTLPMI--LPQHRENPCAAERATCEPTYGYR 211
            |||..|..||.:||:|:|.:|.|:.||||||.||..:|.:  :|::...||    |.|..|||:.
  Fly   199 DDKAKLSTLGDKLSETMKRITNNFHLGFGSFVDKVLMPYVSTIPKNLVEPC----ANCTATYGFH 259

  Fly   212 HQLSLTDDIPAFTSAVANSKITGNLDNLEGGLDALMQVIVCTKEIGWKEQARKVVILVTDGFMHL 276
            ||:.|..:|..||:.|.|:.::||||..|||.||:||.|.|..:|||:||||::::..||...|.
  Fly   260 HQMVLDKNITQFTNEVKNATVSGNLDAPEGGFDAIMQAIACRSQIGWREQARRLLVFSTDAGFHY 324

  Fly   277 AGDGLLAGIIQRNDKQCHLNKAGEYTGSLNYDYPSLEEIYRELLRRKINVIFAVTEEVVSSYWEL 341
            ||||.|.|:|..||.:|||:..||||.|...||||:.:|.:::....||:|||||...:|.|.:|
  Fly   325 AGDGKLGGVIAPNDGECHLSPKGEYTHSTLQDYPSISQINQKVKDNAINIIFAVTASQLSVYEKL 389

  Fly   342 SALMKEISYVDILSA-----DSSNILELIKKSYESLIKRTQFADNSPDFIDMAYYTDCGGQFPSL 401
                  :.::...||     ||||::||:|:.|..:....:..||:...:.:.|::.|....|.:
  Fly   390 ------VEHIQGSSAAKLDNDSSNVVELVKEEYRKISSSVEMKDNATGDVKITYFSSCLSNGPEV 448

  Fly   402 QKRNYCNNVTLGKQIDFYVDVTLKKYP-DNQVYTHKIRVEETSLSEFMDLDVELQRPCPCQETPD 465
            | .:.|:|:..|:|:.|...:.|.|.| |.:.:|..|.:....::|.|.:.:.:...|||:....
  Fly   449 Q-TSKCDNLKEGQQVSFTAQIQLLKCPEDPRDWTQTIHISPVGINEVMQIQLTMLCSCPCENPGS 512

  Fly   466 PENEEGRFLCDYKGYLYCGMCECDEGWTGTYCNCPTDATNVTSNEALLQKCRQPFSDKSTSELVC 530
            ...:.....|...|...||:|.||:.:.|..|.|  .||::||..|....||.    .|||...|
  Fly   513 IGYQVQANSCSGHGTSMCGICNCDDSYFGNKCEC--SATDLTSKFANDTSCRA----DSTSTTDC 571

  Fly   531 SNHGDCDCGTCLCD--PG----YTGPFCECRECLDCDEKL---------ADCFCGQCVCKYGWSG 580
            |..|.|.||.|.|.  |.    .:|..||| :...|:...         ..|.||:|.||.||:|
  Fly   572 SGRGHCVCGACECHKRPNPIEIISGKHCEC-DNFSCERNRNQLCSGPDHGTCECGRCKCKPGWTG 635

  Fly   581 SKCNCDGDTDACVGP-TGEICSERGTCQCEECQC----EEPYLGKFCEIDPEKDNKLCLFYEPCV 640
            |.|.|....|.|:.| .|||||..|||:|..|:|    :..:.|:.||..|....: |...:.||
  Fly   636 SNCGCQESNDTCMPPGGGEICSGHGTCECGVCKCTVNDQGRFSGRHCEKCPTCSGR-CQELKDCV 699

  Fly   641 TCLI----EQKQGMGVCENLTEICSSLDRQETYPYNFVH------ELDPEQDQCLVRLVNKHGIQ 695
            .|.:    |.|.|.....|.|:              ||.      |:|..:|:.:.:..::.  .
  Fly   700 QCQMYKTGELKNGDDCARNCTQ--------------FVPVGVEKVEIDETKDEQMCKFFDED--D 748

  Fly   696 CDSFFVYQVIDHSNFLTIQAVDCEPPDYVALVGYIS---AFTLLIGLLIIFIILWYI--RAKDAR 755
            |...|.|......:....:..:|  |..|.::|.:.   |..:|:||.|  ::||.:  ...|.|
  Fly   749 CKFMFKYSEQGELHVYAQENKEC--PAKVFMLGIVMGVIAAIVLVGLAI--LLLWKLLTTIHDRR 809

  Fly   756 EYAKFEEDQKNSV--RQENPIYRDPVGRYEVP 785
            |:|:||:::.|:.  ..|||||:.....::.|
  Fly   810 EFARFEKERMNAKWDTGENPIYKQATSTFKNP 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Itgbn	NP_001303333.1	INB	38..460	CDD:197563	158/476 (33%)
		EGF_2	524..552	CDD:285248	13/33 (39%)
		Integrin_b_cyt	748..785	CDD:285884	12/40 (30%)
mys	NP_001284997.1	INB	45..505	CDD:197563	157/474 (33%)
		Integrin_B_tail	692..773	CDD:285239	18/98 (18%)
		Integrin_b_cyt	803..843	CDD:285884	13/39 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467877
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1226
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3795
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D12534at7147
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100678
Panther	1	1.100	-	-	P	PTHR10082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.700