DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Itgbn and itgb1

DIOPT Version :9

Sequence 1:	NP_001303333.1	Gene:	Itgbn / 35368	FlyBaseID:	FBgn0010395	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	XP_012819879.1	Gene:	itgb1 / 394767	XenbaseID:	XB-GENE-946725	Length:	801	Species:	Xenopus tropicalis

Alignment Length:	794	Identity:	273/794 - (34%)
Similarity:	412/794 - (51%)	Gaps:	75/794 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 HADSCERCLSAHLECAWCTDKEY-QVG----YRCLSRRQLLNYNCSETDIYENQPVLDVLQDKPL 94
            :|.||..|:.|...|.|||...: |.|    .||.....|.|..|.|.||...:.....|:|.|:
Frog    32 NAKSCGECIQAGPNCGWCTKVNFLQEGEPTSARCDDLAALKNKGCPEEDIQNPRGRKQKLKDIPI 96

  Fly    95 KDY---ETSDQA--VQVTPQRAYLKLVKGNTQRMKLSYRTARNNPLDLYVLMDLTWTMRDDKKTL 154
            .:.   |..|.|  .|:.||:...:|..|..|...|::|.|.:.|:|||.||||:::|:||.:.:
Frog    97 TNKGKGERMDPANITQIRPQQLVFELRSGEPQTFNLTFRRAEDYPIDLYYLMDLSFSMKDDLENV 161

  Fly   155 EELGAQLSQTLKNLTGNYRLGFGSFADKPTLPMI--LPQHRENPCAAERATCEPTYGYRHQLSLT 217
            :.||..|...::.:|.::|:|||||.:|..:|.|  .|....|||.::: .|...:.|::.|:||
Frog   162 KSLGTALMTEMEKITSDFRIGFGSFVEKTVMPYISTTPAKLINPCTSDQ-NCTSPFSYKNVLNLT 225

  Fly   218 DDIPAFTSAVANSKITGNLDNLEGGLDALMQVIVCTKEIGWKEQARKVVILVTDGFMHLAGDGLL 282
            .|...|...|...:|:||||:.|||.||:|||.||.::|||:...| :::..||...|.||||.|
Frog   226 SDGKLFNDLVGKQQISGNLDSPEGGFDAIMQVAVCGEQIGWRNVTR-LLVFSTDAGFHFAGDGKL 289

  Fly   283 AGIIQRNDKQCHLNKAGEYTGSLNYDYPSLEEIYRELLRRKINVIFAVTEEVVSSYWELSALMKE 347
            .||:..||.:|||: ...||.|..|||||:..:.::|....|..||||||:....|.||..|:.:
Frog   290 GGIVLPNDGKCHLH-GNMYTMSHYYDYPSIAHLVQKLSENNIQTIFAVTEDFQPVYQELKNLIPK 353

  Fly   348 ISYVDILSADSSNILELIKKSYESLIKRTQFADNS--PDFIDMAYYTDC-GGQFPSLQKRNYCNN 409
             |.|..||::|||:::||..||.||.... ..:||  |:.:.::|.:.| .|...:.:....|:|
Frog   354 -SAVGTLSSNSSNVIQLIIDSYNSLSSEL-ILENSKLPEGVTISYKSFCKNGVKGTGEDGRKCSN 416

  Fly   410 VTLGKQIDFYVDVTLKKYPDNQVYTHKIRVEETSLSEFMDLDVELQRPCPCQETPDPENEEGRFL 474
            :::|.|::|.:.||..|.| .:.....|:::....:|.:::.::....|.|||...|.:.|
Frog   417 ISIGDQVEFEISVTAHKCP-KKGQAESIKIKPLGFTEEVEIVLQFICECDCQEKGTPNSPE---- 476

  Fly   475 CDY-KGYLYCGMCECDEGWTGTYCNCPTDATNVTSNEALLQKCRQPFSDKSTSELVCSNHGDCDC 538
            |.: .|...||.|.|:||..|..|.|.||..|....:|.   ||:    :::|| :|||:|||.|
Frog   477 CHHGNGTFECGACRCNEGRIGKECECSTDEVNSEDMDAY---CRR----ENSSE-ICSNNGDCIC 533

  Fly   539 GTCLC----DPG--YTGPFCECRECLDCDEK-------LADCFCGQCVCKYGWSGSKCNCDGDTD 590
            |.|:|    :|.  |:|.:||| :..:||..       ...|.|..|.|...:|||.|:|..||.
Frog   534 GQCVCKKRDNPNEVYSGKYCEC-DNFNCDRSNGLICGGKGVCKCRVCECFPNYSGSACDCSEDTS 597

  Fly   591 ACVGPTGEICSERGTCQCEECQCEEP-YLGKFCEIDPEKDNKLCLFYEPCVTCLIEQK-QGMGVC 653
            .|:...|:||:.||.|.|..|:|.:| :.|..||: .:....:|..::.||.|...|| :...||
Frog   598 TCMAKNGQICNGRGICDCGRCKCTDPKFQGPTCEL-CQTCVGVCTEHKECVQCRAFQKGEKQEVC 661

  Fly   654 ENLTEIC-----SSLDRQETYPYNFVHELDPEQDQCLVRLVNKHGIQCDSFFVYQVIDHSNFLTI 713
               .|.|     |.::.:|..|       .|.|.:.|.....|....|..:|.|.| |..|.:.:
Frog   662 ---LEQCMHFNISLVESREDLP-------QPGQAEALTHCKEKDAEDCWFYFTYSV-DSKNEVLV 715

  Fly   714 QAVDCEP-----PDYVALVGYISAFTLLIGLLIIFIILWYIRAKDAREYAKFEEDQKNSV--RQE 771
            ..|. ||     ||.:.:|..:.|..:||||.::.|....:...|.||:||||:::.|:.  .||
Frog   716 HVVK-EPECPSGPDIIPIVAGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTQE 779

  Fly   772 NPIYRDPVGRYEVP 785
            ||||:.|:..::.|
Frog   780 NPIYKSPINNFKNP 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Itgbn	NP_001303333.1	INB	38..460	CDD:197563	154/436 (35%)
		EGF_2	524..552	CDD:285248	15/33 (45%)
		Integrin_b_cyt	748..785	CDD:285884	15/38 (39%)
itgb1	XP_012819879.1	INB	35..464	CDD:197563	153/434 (35%)
		I-EGF_1	466..495	CDD:375798	12/32 (38%)
		EGF_2	599..630	CDD:285248	12/30 (40%)
		Integrin_B_tail	640..727	CDD:369622	26/98 (27%)
		Integrin_b_cyt	757..796	CDD:370082	16/37 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10082
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.110