Protein Alignment Itgbn and ITGB7

DIOPT Version :10

• Sequence 1: NP_523608.2
• Gene: Itgbn / 35368
• FlyBaseID: FBgn0010395
• Length: 799
• Species: Drosophila melanogaster
• Sequence 2: NP_000880.1
• Gene: ITGB7 / 3695
• HGNCID: 6162
• Length: 798
• Species: Homo sapiens
• Alignment Length: 787
• Identity: 244/787 - (31%)
• Similarity: 370/787 - (47%)
• Gaps: 89/787 - (11%)

  Fly    33 CRHADSCERCLSAHLECAWCTDKEYQV-----GYRCLSRRQLLNYNCSETDIYENQPVLDVLQDK 92
            |:.|.||::|:.:|..||||....:..     ..||..|.:||...|...::.|.:...:||||:
Human    45 CQPAPSCQKCILSHPSCAWCKQLNFTASGEAEARRCARREELLARGCPLEELEEPRGQQEVLQDQ 109

  Fly    93 PLKDYETSDQAVQVTPQRAYLKLVKGNTQRMKLSYRTARNNPLDLYVLMDLTWTMRDDKKTLEEL 157
            ||......:.|.|:.|||..:.|..|..|::::.:..|...|:|||.||||:::|:||.:.:.:|
Human   110 PLSQGARGEGATQLAPQRVRVTLRPGEPQQLQVRFLRAEGYPVDLYYLMDLSYSMKDDLERVRQL 174

  Fly   158 GAQLSQTLKNLTGNYRLGFGSFADKPTLPMI--LPQHRENPCAAERATCEPTYGYRHQLSLTDDI 220
            |..|...|:.:|.:.|:|||||.||..||.:  :|....:||......|:..:.:.|.||||.|.
Human   175 GHALLVRLQEVTHSVRIGFGSFVDKTVLPFVSTVPSKLRHPCPTRLERCQSPFSFHHVLSLTGDA 239

  Fly   221 PAFTSAVANSKITGNLDNLEGGLDALMQVIVCTKEIGWKEQARKVVILVTDGFMHLAGDGLLAGI 285
            .||...|....::||||:.|||.||::|..:|.::|||:..:| :::..:|...|.||||.|.||
Human   240 QAFEREVGRQSVSGNLDSPEGGFDAILQAALCQEQIGWRNVSR-LLVFTSDDTFHTAGDGKLGGI 303

  Fly   286 IQRNDKQCHLNKAGEYTGSLNYDYPSLEEIYRELLRRKINVIFAVTEEVVSSYWELSALMKEISY 350
            ...:|..|||:..|.|:.|..:||||:.::.:.|....|..|||||...:..|.|||.|:.: |.
Human   304 FMPSDGHCHLDSNGLYSRSTEFDYPSVGQVAQALSAANIQPIFAVTSAALPVYQELSKLIPK-SA 367

  Fly   351 VDILSADSSNILELIKKSYESLIKRTQFADNS-PDFIDMAYYTDCGG---QFPSLQKRNYCNNVT 411
            |..||.||||:::||..:|.||........:| |..:.::|.:.|.|   :....:.|..||:|.
Human   368 VGELSEDSSNVVQLIMDAYNSLSSTVTLEHSSLPPGVHISYESQCEGPEKREGKAEDRGQCNHVR 432

  Fly   412 LGKQIDFYVDVTLKK-YPDNQVYTHKIRVEETSLSEFMDLDVELQRPCPCQ----ETPDPENEEG 471
            :.:.:.|:|.:.... .|:    .|.:|:.....||  :|.|||...|.|.    :...|...:|
Human   433 INQTVTFWVSLQATHCLPE----PHLLRLRALGFSE--ELIVELHTLCDCNCSDTQPQAPHCSDG 491

  Fly   472 RFLCDYKGYLYCGMCECDEGWTGTYCNCPTDATNVTSNEALLQKCRQPFSDKSTSELVCSNHGDC 536
                  :|:|.||:|.|..|..|..|.|   :....|:..|...||.|   ..|..| ||..|.|
Human   492 ------QGHLQCGVCSCAPGRLGRLCEC---SVAELSSPDLESGCRAP---NGTGPL-CSGKGHC 543

  Fly   537 DCGTCLCDPGYTGPFCECRECLDCDEK-------LADCFCGQCVCKYGWSGSKCNCDGDTDACVG 594
            .||.|.|....:|..|||.:. .|:..       ...|.||.|.|....:|..|.|.||.|:|:.
Human   544 QCGRCSCSGQSSGHLCECDDA-SCERHEGILCGGFGRCQCGVCHCHANRTGRACECSGDMDSCIS 607

  Fly   595 PTGEICSERGTCQCEECQCEEPYLGKFCEIDPEKDNKLCLFYEPCVTCLIEQKQGMG------VC 653
            |.|.:||..|.|:|..|||.:.|.|..|:..|..... |..:..|..|        |      :.
Human   608 PEGGLCSGHGRCKCNRCQCLDGYYGALCDQCPGCKTP-CERHRDCAEC--------GAFRTGPLA 663

  Fly   654 ENLTEICSSLDRQETYPYNFVHELDPEQDQ--CLVRLVNKHGIQCDSFFVYQVIDHSNFLTI--- 713
            .|.:..|:..        |....|.|..|.  |..|.::      :..|.:.|.|.:....:
Human   664 TNCSTACAHT--------NVTLALAPILDDGWCKERTLD------NQLFFFLVEDDARGTVVLRV 714

  Fly   714 ----QAVDCEPPDYVALVGYISAFTLLIGLLIIFIILWYIRAKDAREYAKFEEDQK--NSVRQEN 772
                :..|......:..||.|.|    :||.::......:...|.|||::||::|:  |..:..|
Human   715 RPQEKGADHTQAIVLGCVGGIVA----VGLGLVLAYRLSVEIYDRREYSRFEKEQQQLNWKQDSN 775

  Fly   773 PIYRDPV 779
            |:|:..:
Human   776 PLYKSAI 782

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Itgbn	NP_523608.2	INB	38..460	CDD:197563	150/433 (35%)
		EGF_2	529..552	CDD:400365	9/22 (41%)
		Integrin_b_cyt	752..785	CDD:462580	11/30 (37%)
ITGB7	NP_000880.1	INB	50..476	CDD:197563	150/433 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	98..124		9/25 (36%)
		I-EGF_1	476..506	CDD:465729	9/35 (26%)
		Integrin_B_tail	645..717	CDD:462325	15/93 (16%)
		Integrin_b_cyt	750..790	CDD:462580	11/33 (33%)