Protein Alignment Itgbn and ITGB5

DIOPT Version :10

• Sequence 1: NP_523608.2
• Gene: Itgbn / 35368
• FlyBaseID: FBgn0010395
• Length: 799
• Species: Drosophila melanogaster
• Sequence 2: NP_002204.2
• Gene: ITGB5 / 3693
• HGNCID: 6160
• Length: 799
• Species: Homo sapiens
• Alignment Length: 784
• Identity: 254/784 - (32%)
• Similarity: 384/784 - (48%)
• Gaps: 68/784 - (8%)

  Fly    36 ADSCERCLSAHLECAWCTDKEY----QVGYRCLSRRQLLNYNCSETDIYENQPVLDVLQDKPLKD 96
            |.|||.||..|.:||||:.:::    .:..||..|..|:...|. .:|........||:..||..
Human    33 ATSCEECLLIHPKCAWCSKEDFGSPRSITSRCDLRANLVKNGCG-GEIESPASSFHVLRSLPLSS 96

  Fly    97 YETSD---QAVQVTPQRAYLKLVKGNTQRMKLSYRTARNNPLDLYVLMDLTWTMRDDKKTLEELG 158
            ..:..   ..:|:|||...:.|..|:....:|..|...:.|:|||.||||:.:|:||...:..||
Human    97 KGSGSAGWDVIQMTPQEIAVNLRPGDKTTFQLQVRQVEDYPVDLYYLMDLSLSMKDDLDNIRSLG 161

  Fly   159 AQLSQTLKNLTGNYRLGFGSFADKPTLPM--ILPQHRENPCAAER--ATCEPTYGYRHQLSLTDD 219
            .:|::.::.||.|:|||||||.||...|.  ..|:::.|||...:  ..|.|::|:||.|.|||.
Human   162 TKLAEEMRKLTSNFRLGFGSFVDKDISPFSYTAPRYQTNPCIGYKLFPNCVPSFGFRHLLPLTDR 226

  Fly   220 IPAFTSAVANSKITGNLDNLEGGLDALMQVIVCTKEIGWKEQARKVVILVTDGFMHLAGDGLLAG 284
            :.:|...|...:::.|.|..|||.||::|..||.::|||::.|..:::..||...|:|.||.|.|
Human   227 VDSFNEEVRKQRVSRNRDAPEGGFDAVLQAAVCKEKIGWRKDALHLLVFTTDDVPHIALDGKLGG 291

  Fly   285 IIQRNDKQCHLNKAGEYTGSLNYDYPSLEEIYRELLRRKINVIFAVTEEVVSSYWELSALMKEIS 349
            ::|.:|.|||||:|.|||.|...|||||..:..:|....||:|||||:.....|...:||:...:
Human   292 LVQPHDGQCHLNEANEYTASNQMDYPSLALLGEKLAENNINLIFAVTKNHYMLYKNFTALIPGTT 356

  Fly   350 YVDILSADSSNILELIKKSYESLIKRTQFAD-NSPDFIDMAYYTDC--GGQFPSLQKRNYCNNVT 411
             |:||..||.||::||..:|.|:..:.:.:. :.|:.:::.:...|  |..:|..:|   |..:.
Human   357 -VEILDGDSKNIIQLIINAYNSIRSKVELSVWDQPEDLNLFFTATCQDGVSYPGQRK---CEGLK 417

  Fly   412 LGKQIDFYVDVTLKKYPDNQVYTHKIRVEETSLSEFMDLDVELQRPCPCQETPDPENEEGRFLCD 476
            :|....|.|.:..:..|.... .|...:......:.:::.|.....|.|....:|.:..    |:
Human   418 IGDTASFEVSLEARSCPSRHT-EHVFALRPVGFRDSLEVGVTYNCTCGCSVGLEPNSAR----CN 477

  Fly   477 YKGYLYCGMCECDEGWTGTYCNCPTDATNVTSNEALLQK-CRQPFSDKSTSELVCSNHGDCDCGT 540
            ..|...||:|||..|:.||.|.|...     .|:::.|. ||:     :..:.:||..|||.|..
Human   478 GSGTYVCGLCECSPGYLGTRCECQDG-----ENQSVYQNLCRE-----AEGKPLCSGRGDCSCNQ 532

  Fly   541 CLCDPG----YTGPFCECRECLDCDEKL-------ADCFCGQCVCKYGWSGSKCNCDGDTDACVG 594
            |.|...    ..|||||| :...|....       .:|.||:|.|..|:.|..|||..|...|.|
Human   533 CSCFESEFGKIYGPFCEC-DNFSCARNKGVLCSGHGECHCGECKCHAGYIGDNCNCSTDISTCRG 596

  Fly   595 PTGEICSERGTCQCEECQCEEP-YLGKFCEIDPEKDNKLCLFYEPCVTCLIEQKQGMGVCENLTE 658
            ..|:||||||.|.|.:|||.|| ..|:.||..|...: .|.....||.||:...   |..:|.|
Human   597 RDGQICSERGHCLCGQCQCTEPGAFGEMCEKCPTCPD-ACSTKRDCVECLLLHS---GKPDNQT- 656

  Fly   659 ICSSLDRQE--TYPYNFVHELDPEQDQCLVRLVNKHGIQCDSFFVYQVI--DHSNFLTIQAVDC- 718
             |.||.|.|  |:....|     :.||..|....|....|...|.|..:  ..||...::..:|
Human   657 -CHSLCRDEVITWVDTIV-----KDDQEAVLCFYKTAKDCVMMFTYVELPSGKSNLTVLREPECG 715

  Fly   719 EPPDYVALVGYISAFTLLIGLLIIFIILWYIRAKDAREYAKFEEDQKNSVRQE---NPIYRDPVG 780
            ..|:.:.::..:....||:||.::.|....:...|.||:||| :.:::..|.|   ||:||.|:.
Human   716 NTPNAMTILLAVVGSILLVGLALLAIWKLLVTIHDRREFAKF-QSERSRARYEMASNPLYRKPIS 779

  Fly   781 RYEV 784
            .:.|
Human   780 THTV 783

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Itgbn	NP_523608.2	INB	38..460	CDD:197563	144/435 (33%)
		EGF_2	529..552	CDD:400365	10/26 (38%)
		Integrin_b_cyt	752..785	CDD:462580	14/36 (39%)
ITGB5	NP_002204.2	INB	35..463	CDD:197563	143/433 (33%)
		I-EGF_1	465..493	CDD:465729	9/31 (29%)
		Integrin_B_tail	635..714	CDD:462325	24/88 (27%)
		Integrin_b_cyt	746..781	CDD:462580	13/35 (37%)