DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Itgbn and ITGB3

DIOPT Version :9

Sequence 1:	NP_001303333.1	Gene:	Itgbn / 35368	FlyBaseID:	FBgn0010395	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	NP_000203.2	Gene:	ITGB3 / 3690	HGNCID:	6156	Length:	788	Species:	Homo sapiens

Alignment Length:	790	Identity:	254/790 - (32%)
Similarity:	389/790 - (49%)	Gaps:	84/790 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 RHADSCERCLSAHLECAWCTDKEYQVGY-RCLSRRQLLNYNCSETDIYENQPVLD--VLQDKPLK 95
            |...||::||:....||||:|:...:|. ||..:..||..||:...|  ..||.:  ||:|:||.
Human    34 RGVSSCQQCLAVSPMCAWCSDEALPLGSPRCDLKENLLKDNCAPESI--EFPVSEARVLEDRPLS 96

  Fly    96 DYETSD--QAVQVTPQRAYLKLVKGNTQRMKLSYRTARNNPLDLYVLMDLTWTMRDDKKTLEELG 158
            |..:.|  |..||:|||..|:|...:::...:..|...:.|:|:|.||||:::|:||..:::.||
Human    97 DKGSGDSSQVTQVSPQRIALRLRPDDSKNFSIQVRQVEDYPVDIYYLMDLSYSMKDDLWSIQNLG 161

  Fly   159 AQLSQTLKNLTGNYRLGFGSFADKPTLPMIL---PQHRENPCAAERATCEPTYGYRHQLSLTDDI 220
            .:|:..::.||.|.|:|||:|.|||..|.:.   |:..||||...:.||.|.:||:|.|:|||.:
Human   162 TKLATQMRKLTSNLRIGFGAFVDKPVSPYMYISPPEALENPCYDMKTTCLPMFGYKHVLTLTDQV 226

  Fly   221 PAFTSAVANSKITGNLDNLEGGLDALMQVIVCTKEIGWKEQARKVVILVTDGFMHLAGDGLLAGI 285
            ..|...|....::.|.|..|||.||:||..||.::|||:..|..:::..||...|:|.||.||||
Human   227 TRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTDAKTHIALDGRLAGI 291

  Fly   286 IQRNDKQCHLNKAGEYTGSLNYDYPSLEEIYRELLRRKINVIFAVTEEVVSSYWELSALMKEISY 350
            :|.||.|||:.....|:.|...|||||..:..:|.::.||:||||||.||:.|...|.|:...:
Human   292 VQPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVNLYQNYSELIPGTT- 355

  Fly   351 VDILSADSSNILELIKKSYESLIKRTQF-ADNSPDFIDMAYYTDC--GGQFPSLQKRNYCNNVTL 412
            |.:||.||||:|:||..:|..:..:.:. ..:.|:.:.:::...|  ....|.|:.   |..:.:
Human   356 VGVLSMDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKS---CMGLKI 417

  Fly   413 GKQIDFYVDVTLKKYPDNQVYTHKIRVEETSLSEFMDLDVELQRPCPCQETPDPENEEGRFLCDY 477
            |..:.|.::..::..|  |.......::.....:.:.:.|.....|.||...:|.:..    |:.
Human   418 GDTVSFSIEAKVRGCP--QEKEKSFTIKPVGFKDSLIVQVTFDCDCACQAQAEPNSHR----CNN 476

  Fly   478 -KGYLYCGMCECDEGWTGTYCNCPTDATNVTSNEALLQKCRQPFSDKSTSELVCSNHGDCDCGTC 541
             .|...||:|.|..||.|:.|.|..:....:..:....:..||         |||..|:|.||.|
Human   477 GNGTFECGVCRCGPGWLGSQCECSEEDYRPSQQDECSPREGQP---------VCSQRGECLCGQC 532

  Fly   542 LC---DPG-YTGPFCECRE--CLDCDEKL----ADCFCGQCVCKYGWSGSKCNCDGDTDACVGPT 596
            :|   |.| .||.:|||.:  |:....::    ..|.||.|:|...|:|..|||...||.|:...
Human   533 VCHSSDFGKITGKYCECDDFSCVRYKGEMCSGHGQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSN 597

  Fly   597 GEICSERGTCQCEECQCEEP-YLGKFCEIDPEKDNKLCLFYEPCVTCLIEQKQGMGVCENLTEIC 660
            |.:||.||.|:|..|.|.:| ..|..||..|...: .|.|.:.||.|   :|...|...: ...|
Human   598 GLLCSGRGKCECGSCVCIQPGSYGDTCEKCPTCPD-ACTFKKECVEC---KKFDRGALHD-ENTC 657

  Fly   661 SSLDRQETYPYNFVHELD-----------PEQDQCLVRLVNKHGIQCDSFFVYQVIDHSNFLTIQ 714
            :...|.|   ...|.||.           ..:|.|:||              :|..:.|:..:|.
Human   658 NRYCRDE---IESVKELKDTGKDAVNCTYKNEDDCVVR--------------FQYYEDSSGKSIL 705

  Fly   715 AVDCEP-----PDYVALVGYISAFTLLIGLLIIFIILWYIRAKDAREYAKFEEDQKNSV--RQEN 772
            .|..||     ||.:.::..:....|||||..:.|....|...|.:|:|||||::..:.  ...|
Human   706 YVVEEPECPKGPDILVVLLSVMGAILLIGLAALLIWKLLITIHDRKEFAKFEEERARAKWDTANN 770

  Fly   773 PIYRDPVGRY 782
            |:|::....:
Human   771 PLYKEATSTF 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Itgbn	NP_001303333.1	INB	38..460	CDD:197563	151/432 (35%)
		EGF_2	524..552	CDD:285248	13/31 (42%)
		Integrin_b_cyt	748..785	CDD:285884	11/37 (30%)
ITGB3	NP_000203.2	Integrin_beta	38..461	CDD:278776	150/430 (35%)
		Involved in CX3CL1-, NRG1-, FGF1-and IGF1-binding. /evidence=ECO:0000269\|PubMed:18441324, ECO:0000269\|PubMed:19578119, ECO:0000269\|PubMed:20682778, ECO:0000269\|PubMed:23125415	203..210		1/6 (17%)
		CX3CL1-binding. /evidence=ECO:0000269\|PubMed:24789099	293..313		8/19 (42%)
		Cysteine-rich tandem repeats	463..629		59/178 (33%)
		Integrin_B_tail	634..717	CDD:285239	23/103 (22%)
		Integrin_b_cyt	744..786	CDD:285884	11/37 (30%)
		LIR. /evidence=ECO:0000305\|PubMed:33436497, ECO:0000305\|PubMed:33436498	777..783		0/4 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159899
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1226
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100678
Panther	1	1.100	-	-	O	PTHR10082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750