DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Itgbn and ITGB2

DIOPT Version :9

Sequence 1:	NP_001303333.1	Gene:	Itgbn / 35368	FlyBaseID:	FBgn0010395	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	NP_000202.3	Gene:	ITGB2 / 3689	HGNCID:	6155	Length:	769	Species:	Homo sapiens

Alignment Length:	787	Identity:	254/787 - (32%)
Similarity:	380/787 - (48%)	Gaps:	71/787 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 IDDQCR--HADSCERCLSAHLECAWCTDKEY-----QVGYRCLSRRQLLNYNCSETDIYENQPVL 86
            :..:|.  ...||..|:.:...|.||....:     ....||.:|.|||...|:..||.:...:.
Human    21 LSQECTKFKVSSCRECIESGPGCTWCQKLNFTGPGDPDSIRCDTRPQLLMRGCAADDIMDPTSLA 85

  Fly    87 DVLQDKPLKDYETSDQAVQVTPQRAYLKLVKGNTQRMKLSYRTARNNPLDLYVLMDLTWTMRDDK 151
            :..:|.       :....|::||:..|.|..|......:::|.|:..|:|||.||||:::|.||.
Human    86 ETQEDH-------NGGQKQLSPQKVTLYLRPGQAAAFNVTFRRAKGYPIDLYYLMDLSYSMLDDL 143

  Fly   152 KTLEELGAQLSQTLKNLTGNYRLGFGSFADKPTLPMI--LPQHRENPCAAERATCEPTYGYRHQL 214
            :.:::||..|.:.|..:|.:.|:|||||.||..||.:  .|....|||..:...|:|.:.:||.|
Human   144 RNVKKLGGDLLRALNEITESGRIGFGSFVDKTVLPFVNTHPDKLRNPCPNKEKECQPPFAFRHVL 208

  Fly   215 SLTDDIPAFTSAVANSKITGNLDNLEGGLDALMQVIVCTKEIGWKEQARKVVILVTDGFMHLAGD 279
            .||::...|.:.|....|:||||..||||||:|||..|.:||||:...|.:|....||| |.|||
Human   209 KLTNNSNQFQTEVGKQLISGNLDAPEGGLDAMMQVAACPEEIGWRNVTRLLVFATDDGF-HFAGD 272

  Fly   280 GLLAGIIQRNDKQCHLNKAGEYTGSLNYDYPSLEEIYRELLRRKINVIFAVTEEVVSSYWELSAL 344
            |.|..|:..||.:||| :...|..|..:||||:.::..:|....|..|||||..:|.:|.:|:.:
Human   273 GKLGAILTPNDGRCHL-EDNLYKRSNEFDYPSVGQLAHKLAENNIQPIFAVTSRMVKTYEKLTEI 336

  Fly   345 MKEISYVDILSADSSNILELIKKSYESLIKRTQFADNS--PDFIDMAYYTDC-GGQFPSLQKRNY 406
            :.: |.|..||.||||::.|||.:|..|..|. |.|::  ||.:.:.|.:.| .|.....|.|..
Human   337 IPK-SAVGELSEDSSNVVHLIKNAYNKLSSRV-FLDHNALPDTLKVTYDSFCSNGVTHRNQPRGD 399

  Fly   407 CNNVTLGKQIDFYVDVTLKKYPDNQVYTHKIRVEETSLSEFMDLDVELQRPCPCQETPDPENEEG 471
            |:.|.:...|.|.|.||..:....|.:.    :.....::.:.:.|..|..|.|:     :....
Human   400 CDGVQINVPITFQVKVTATECIQEQSFV----IRALGFTDIVTVQVLPQCECRCR-----DQSRD 455

  Fly   472 RFLCDYKGYLYCGMCECDEGWTGTYCNCPTDATNVTSNEALLQKCRQPFSDKSTSELVCSNHGDC 536
            |.||..||:|.||:|.||.|:.|..|.|.|..   .|::.|...||     |..:.::||..|||
Human   456 RSLCHGKGFLECGICRCDTGYIGKNCECQTQG---RSSQELEGSCR-----KDNNSIICSGLGDC 512

  Fly   537 DCGTCLCD----PG--YTGPFCECRECLDCDEKLAD---------CFCGQCVCKYGWSGSKCNCD 586
            .||.|||.    ||  ..|.:||| :.::|:.....         ||||:|.|..|:.||.|.|:
Human   513 VCGQCLCHTSDVPGKLIYGQYCEC-DTINCERYNGQVCGGPGRGLCFCGKCRCHPGFEGSACQCE 576

  Fly   587 GDTDACVGPTGEICSERGTCQCEECQCEEPYLGKFCEIDPEKDNKLCLFYEPCVTCLIEQKQGMG 651
            ..|:.|:.|....||.||.|:|..|:|...|....|:..|...:. |..|..|..||..:|...|
Human   577 RTTEGCLNPRRVECSGRGRCRCNVCECHSGYQLPLCQECPGCPSP-CGKYISCAECLKFEKGPFG 640

  Fly   652 VCENLTEICSSLDRQETYPYNFVHELDPEQDQCLVRLVNKHGIQCDSFFVYQVIDHSNFLTIQAV 716
              :|.:..|..|..... |.......:.:.:.|.|....:.....|.:.:|  :|.|.
Human   641 --KNCSAACPGLQLSNN-PVKGRTCKERDSEGCWVAYTLEQQDGMDRYLIY--VDESR------- 693

  Fly   717 DC-EPPDYVALVGYISAFTLLIGLLIIFIILWYIRAKDAREYAKFEEDQ-KNSVRQENPIYRDPV 779
            :| ..|:..|:||...|..:|||:|::.|....|...|.|||.:||::: |:....:||:::...
Human   694 ECVAGPNIAAIVGGTVAGIVLIGILLLVIWKALIHLSDLREYRRFEKEKLKSQWNNDNPLFKSAT 758

  Fly   780 GRYEVPK 786
            .....||
Human   759 TTVMNPK 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Itgbn	NP_001303333.1	INB	38..460	CDD:197563	149/431 (35%)
		EGF_2	524..552	CDD:285248	13/33 (39%)
		Integrin_b_cyt	748..785	CDD:285884	10/37 (27%)
ITGB2	NP_000202.3	INB	32..447	CDD:197563	148/429 (34%)
		Cell attachment site. /evidence=ECO:0000255	397..399		1/1 (100%)
		Cysteine-rich tandem repeats	449..617		63/181 (35%)
		Integrin_B_tail	622..699	CDD:311770	18/88 (20%)
		Integrin_b_cyt	726..767	CDD:312304	12/40 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100678
Panther	1	1.100	-	-	O	PTHR10082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920