Protein Alignment Itgbn and Itgb8

DIOPT Version :10

• Sequence 1: NP_523608.2
• Gene: Itgbn / 35368
• FlyBaseID: FBgn0010395
• Length: 799
• Species: Drosophila melanogaster
• Sequence 2: NP_001388746.1
• Gene: Itgb8 / 362800
• RGDID: 1311374
• Length: 767
• Species: Rattus norvegicus
• Alignment Length: 841
• Identity: 233/841 - (27%)
• Similarity: 357/841 - (42%)
• Gaps: 176/841 - (20%)

  Fly    11 WIY-LVFLIAEISHSDADSIDDQCRHADSCERCLSAHLECAWCTDKEYQVG----YRCLSRRQLL 70
            |:: ||..:.:..|:..||     .:..||.|||....||.||..:::..|    .||.:...|:
  Rat    31 WVFSLVLGLGQSEHNRCDS-----ANVVSCARCLQLGPECGWCVQEDFVSGGSRSERCDTVSNLI 90

  Fly    71 NYNCSETDIYENQPVLDVLQDKPLKDYETSDQAV--QVTPQRAYLKLVKGNTQRMKLSYRTARNN 133
            :..|         || |.::...:....:|:..:  ||||....::|..|......|..|..:..
  Rat    91 SKGC---------PV-DSIEYLSVHVVTSSENEINTQVTPGDVSIQLHPGAEANFMLKIRPLKKY 145

  Fly   134 PLDLYVLMDLTWTMRDDKKTLEELGAQLSQTLKNLTGNYRLGFGSFADKPTLPMIL--PQHRENP 196
            |:|||.|:|::.:|.::.:.|..:|..||:.:...:.::||||||:.||...|.|.  |:...|.
  Rat   146 PVDLYYLVDVSASMHNNIEKLNSVGNDLSKKMALFSHDFRLGFGSYVDKTVSPYISIHPERIHNQ 210

  Fly   197 CAAERATCEPTYGYRHQLSLTDDIPAFTSAVANSKITGNLDNLEGGLDALMQVIVCTKEIGWKEQ 261
            |:.....|.|.:||.|.||||::|..|..||...||:||:|..|||.||::|..||...|||:::
  Rat   211 CSDYNLDCMPPHGYIHVLSLTENITEFEKAVHRQKISGNIDTPEGGFDAMLQAAVCESHIGWRKE 275

  Fly   262 ARKVVILVTDGFMHLAGDGLLAGIIQRNDKQCHLNKAGEYTGSLNYDYPSLEEIYRELLRRKINV 326
            |:::::::||...|||.|..||||:..||..||| |...|..|...::|||.::..:|:...|||
  Rat   276 AKRLLLVMTDQTSHLALDSKLAGIVVPNDGNCHL-KNNVYVKSTTMEHPSLGQLSEKLIDNNINV 339

  Fly   327 IFAVTEEVVSSYWELSALMKEISYVDILSADSSNILELIKKSYESLIKRTQFADNS--------- 382
            ||||..:....|.:|..|:.. :....:.:.::|:..|:.::|:.||...:....|
  Rat   340 IFAVQGKQFHWYKDLLPLLPG-AIAGEIESKAANLNNLVVEAYKKLISEVKVQLESQVHGVHFNI 403

  Fly   383 ----PDFIDMAYYTDCGGQFPSLQKRNYCNNVTLGKQIDFYVDVTLKKYP----DNQVYTHKIRV 439
                ||          |.:.|.   .:.|.|||...::.|.|.|.:|...    .|......|..
  Rat   404 TAICPD----------GARKPG---TSGCGNVTSNDEVLFNVTVVMKTCDIIGGKNYAIIKPIGF 455

  Fly   440 EETSLSEFMDLDVELQRPCPCQETPDPENEEGRFLC-DYKGYLYCGMC----------ECDEGWT 493
            .||:       .|.:.|.|.||             | |::|..  |.|          :||:|
  Rat   456 NETT-------KVHIHRSCSCQ-------------CEDHRGLK--GQCAEAAPDPKCPQCDDG-- 496

  Fly   494 GTYCNCPTDATNVTSNEALLQKCRQPFSDKSTSELVCSNHGDCDCGTCLCDP----GYTGPFCEC 554
                .|..|.....|     :.|: |..|:.    |||..|.|.||.|||..    ...|.:||
  Rat   497 ----KCHFDEDQFPS-----EACK-PQEDQP----VCSGRGVCICGKCLCHKTKLGRVYGQYCE- 546

  Fly   555 RECLDCDEKLAD-------CFCGQCVCKYGWSGSKCNC-DGDTDACVGPTGEICSERGTCQCEEC 611
            ::...|.....|       |..|:|.|..||.|.:|.| ......||...|::||.||||.|..|
  Rat   547 KDDFSCPYLHGDVCSGHGECEGGRCQCFNGWEGDRCQCPSASAQHCVNSKGQVCSGRGTCVCGRC 611

  Fly   612 QCEEPYLGKFCEIDPEKDNKLCLFYEPCVTCLIEQKQGMGVCENLTEICSSLDRQETYPYNFVHE 676
            :|          .||....:||   |.|.||.:...:.....:.|            :|:|....
  Rat   612 EC----------TDPRSIGRLC---EHCPTCHLSCSENWNCLQCL------------HPHNLSQA 651

  Fly   677 LDPEQDQCLV--RLVNKHGIQCDSFFVYQVIDHSNFLTIQAVDC-EPPDYVALVGYISAFTLLIG 738
            :   .|||..  .::.:|.:                  .|..:| ..|.|:.:...|...|.|||
  Rat   652 V---LDQCKASCAVMEQHPV------------------AQTSECLSGPSYLRIFFIIFIVTFLIG 695

  Fly   739 LLIIFIILWYI------RAKDAREYAKFEEDQKNSVRQENPIYRDPVGRYEVPKALSVKYD 793
            ||.:.||...|      :.|.:.:| :....:|:.:..::...|....|.|.|:  .:|.|
  Rat   696 LLKVLIIRQVILQWNSNKIKSSSDY-RVSASKKDKLILQSVCTRAVTYRREKPE--EIKMD 753

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Itgbn	NP_523608.2	INB	38..460	CDD:197563	137/446 (31%)
		EGF_2	529..552	CDD:400365	11/26 (42%)
		Integrin_b_cyt	752..785	CDD:462580	6/32 (19%)
Itgb8	NP_001388746.1	INB	54..469	CDD:197563	137/446 (31%)