DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Itgbn and Itgb8

DIOPT Version :9

Sequence 1:	NP_001303333.1	Gene:	Itgbn / 35368	FlyBaseID:	FBgn0010395	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	XP_006240759.1	Gene:	Itgb8 / 362800	RGDID:	1311374	Length:	767	Species:	Rattus norvegicus

Alignment Length:	841	Identity:	233/841 - (27%)
Similarity:	357/841 - (42%)	Gaps:	176/841 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 WIY-LVFLIAEISHSDADSIDDQCRHADSCERCLSAHLECAWCTDKEYQVG----YRCLSRRQLL 70
            |:: ||..:.:..|:..||     .:..||.|||....||.||..:::..|    .||.:...|:
  Rat    31 WVFSLVLGLGQSEHNRCDS-----ANVVSCARCLQLGPECGWCVQEDFVSGGSRSERCDTVSNLI 90

  Fly    71 NYNCSETDIYENQPVLDVLQDKPLKDYETSDQAV--QVTPQRAYLKLVKGNTQRMKLSYRTARNN 133
            :..|         || |.::...:....:|:..:  ||||....::|..|......|..|..:..
  Rat    91 SKGC---------PV-DSIEYLSVHVVTSSENEINTQVTPGDVSIQLHPGAEANFMLKIRPLKKY 145

  Fly   134 PLDLYVLMDLTWTMRDDKKTLEELGAQLSQTLKNLTGNYRLGFGSFADKPTLPMIL--PQHRENP 196
            |:|||.|:|::.:|.::.:.|..:|..||:.:...:.::||||||:.||...|.|.  |:...|.
  Rat   146 PVDLYYLVDVSASMHNNIEKLNSVGNDLSKKMALFSHDFRLGFGSYVDKTVSPYISIHPERIHNQ 210

  Fly   197 CAAERATCEPTYGYRHQLSLTDDIPAFTSAVANSKITGNLDNLEGGLDALMQVIVCTKEIGWKEQ 261
            |:.....|.|.:||.|.||||::|..|..||...||:||:|..|||.||::|..||...|||:::
  Rat   211 CSDYNLDCMPPHGYIHVLSLTENITEFEKAVHRQKISGNIDTPEGGFDAMLQAAVCESHIGWRKE 275

  Fly   262 ARKVVILVTDGFMHLAGDGLLAGIIQRNDKQCHLNKAGEYTGSLNYDYPSLEEIYRELLRRKINV 326
            |:::::::||...|||.|..||||:..||..||| |...|..|...::|||.::..:|:...|||
  Rat   276 AKRLLLVMTDQTSHLALDSKLAGIVVPNDGNCHL-KNNVYVKSTTMEHPSLGQLSEKLIDNNINV 339

  Fly   327 IFAVTEEVVSSYWELSALMKEISYVDILSADSSNILELIKKSYESLIKRTQFADNS--------- 382
            ||||..:....|.:|..|:.. :....:.:.::|:..|:.::|:.||...:....|
  Rat   340 IFAVQGKQFHWYKDLLPLLPG-AIAGEIESKAANLNNLVVEAYKKLISEVKVQLESQVHGVHFNI 403

  Fly   383 ----PDFIDMAYYTDCGGQFPSLQKRNYCNNVTLGKQIDFYVDVTLKKYP----DNQVYTHKIRV 439
                ||          |.:.|.   .:.|.|||...::.|.|.|.:|...    .|......|..
  Rat   404 TAICPD----------GARKPG---TSGCGNVTSNDEVLFNVTVVMKTCDIIGGKNYAIIKPIGF 455

  Fly   440 EETSLSEFMDLDVELQRPCPCQETPDPENEEGRFLC-DYKGYLYCGMC----------ECDEGWT 493
            .||:       .|.:.|.|.||             | |::|..  |.|          :||:|
  Rat   456 NETT-------KVHIHRSCSCQ-------------CEDHRGLK--GQCAEAAPDPKCPQCDDG-- 496

  Fly   494 GTYCNCPTDATNVTSNEALLQKCRQPFSDKSTSELVCSNHGDCDCGTCLCDP----GYTGPFCEC 554
                .|..|.....|     :.|: |..|:.    |||..|.|.||.|||..    ...|.:||
  Rat   497 ----KCHFDEDQFPS-----EACK-PQEDQP----VCSGRGVCICGKCLCHKTKLGRVYGQYCE- 546

  Fly   555 RECLDCDEKLAD-------CFCGQCVCKYGWSGSKCNC-DGDTDACVGPTGEICSERGTCQCEEC 611
            ::...|.....|       |..|:|.|..||.|.:|.| ......||...|::||.||||.|..|
  Rat   547 KDDFSCPYLHGDVCSGHGECEGGRCQCFNGWEGDRCQCPSASAQHCVNSKGQVCSGRGTCVCGRC 611

  Fly   612 QCEEPYLGKFCEIDPEKDNKLCLFYEPCVTCLIEQKQGMGVCENLTEICSSLDRQETYPYNFVHE 676
            :|          .||....:||   |.|.||.:...:.....:.|            :|:|....
  Rat   612 EC----------TDPRSIGRLC---EHCPTCHLSCSENWNCLQCL------------HPHNLSQA 651

  Fly   677 LDPEQDQCLV--RLVNKHGIQCDSFFVYQVIDHSNFLTIQAVDC-EPPDYVALVGYISAFTLLIG 738
            :   .|||..  .::.:|.:                  .|..:| ..|.|:.:...|...|.|||
  Rat   652 V---LDQCKASCAVMEQHPV------------------AQTSECLSGPSYLRIFFIIFIVTFLIG 695

  Fly   739 LLIIFIILWYI------RAKDAREYAKFEEDQKNSVRQENPIYRDPVGRYEVPKALSVKYD 793
            ||.:.||...|      :.|.:.:| :....:|:.:..::...|....|.|.|:  .:|.|
  Rat   696 LLKVLIIRQVILQWNSNKIKSSSDY-RVSASKKDKLILQSVCTRAVTYRREKPE--EIKMD 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Itgbn	NP_001303333.1	INB	38..460	CDD:197563	137/446 (31%)
		EGF_2	524..552	CDD:285248	11/31 (35%)
		Integrin_b_cyt	748..785	CDD:285884	7/42 (17%)
Itgb8	XP_006240759.1	INB	54..469	CDD:197563	137/446 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353964
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1226
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10082
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850