DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Itgbn and itgb4

DIOPT Version :9

Sequence 1:	NP_001303333.1	Gene:	Itgbn / 35368	FlyBaseID:	FBgn0010395	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	XP_005166847.1	Gene:	itgb4 / 335269	ZFINID:	ZDB-GENE-030131-7209	Length:	1931	Species:	Danio rerio

Alignment Length:	795	Identity:	234/795 - (29%)
Similarity:	370/795 - (46%)	Gaps:	121/795 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LGG---RAFLWIYLVFLIAEISHSDADSIDDQCRH-----ADSCERCLSAHLECAWCTDKEYQVG 60
            :||   |..:.|:|:.|.|      .||..|:..|     ..:|..|:.....||:|.|:.:: .
Zfish     1 MGGWAIRLAVGIFLLLLAA------TDSRADEVNHCTAARTKTCSECIQVGAGCAYCPDEVFE-H 58

  Fly    61 YRCLSRRQLLNYNCSE-------TDIYENQPVLDVLQDKPLKDYETSDQAVQVTPQRAYLKLVKG 118
            .||..:..|....||:       ..|.||..:.:.|:..            ||:||...:.|:.|
Zfish    59 ERCDLKENLEAQKCSKIVNFESSRQIQENVKINEQLKQS------------QVSPQLMSMTLLPG 111

  Fly   119 NTQRMKLSYRTARNNPLDLYVLMDLTWTMRDDKKTLEELGAQLSQTLKNLTGNYRLGFGSFADKP 183
            ..:.:::........|||||:|||.:.:|.||...|:.:|.:|::.:.:|:.:|.:|||.|.||.
Zfish   112 EEKEVEMEVFEPTRGPLDLYILMDFSNSMSDDLDNLKRMGEKLARLVGDLSDDYTIGFGKFVDKV 176

  Fly   184 TLPMILPQHRENPCAAERATCEPTYGYRHQLSLTDDIPAFTSAVANSKITGNLDNLEGGLDALMQ 248
            |.|.  ...|....|...:..:|.:.:|:.:.||.:|.:|...:...:|:||||..|||.||::|
Zfish   177 TEPQ--TDMRPAKLAEPWSNSDPPFSFRNVIKLTSNITSFRQKLQKERISGNLDAPEGGFDAILQ 239

  Fly   249 VIVCTKEIGWKEQARKVVILVTDGFMHLAGDG--LLAGIIQRNDKQCHLNKAGEYTGSLNYDYPS 311
            ..||..:|||::.:..:::..|:...|...||  :||||:.|||:|||||..|.||..:..||||
Zfish   240 TAVCQDQIGWRKDSTHLLVFSTESAFHYEADGANVLAGILDRNDEQCHLNVDGNYTHDVRQDYPS 304

  Fly   312 LEEIYRELLRRKINVIFAVTEEVVSSYWELSALMKEISYVDILSADSSNILELIKKSYESLIKRT 376
            :..:.|.|::..|..|||||....|.|.:|.... .|:.:..|..||||||.:::|::|::..:.
Zfish   305 IPTLVRLLVKHNIIPIFAVTNHSYSYYEKLHEYF-PIAELGQLQEDSSNILSILEKAFENIRSKI 368

  Fly   377 QF-ADNSPDFIDMAYYTDCG-----GQFPSLQKRNYCNNVTLGKQIDFYVDVTLKKYPDNQVYTH 435
            .. |::.|..::...::..|     |.|          .:|.|:...|  .|.:|..  |||...
Zfish   369 SIRAEDRPKAVETKIFSQSGTFSEYGNF----------KITPGQTGKF--KVRMKAL--NQVGEE 419

  Fly   436 KI------------RVEETSLSEFMDLDVELQRP-CPCQETPDPENEEGRFLCDYKGYLYCGMCE 487
            .:            ||:.|:.|....::.|:..| |.|::||    .:....|...|.|.||.|:
Zfish   420 PVCKVNQADRAGTLRVKPTTFSSAFKINAEVLCPTCDCEKTP----VKNAVRCTGHGDLVCGKCQ 480

  Fly   488 CDEGWTGTYCNCPTDATNVTSNEALLQKCR-QPFSDKSTSELVCSNHGDCDCGTCLC-DPG-YTG 549
            |..||.|..|||...|:  |.:...:::.: :|          ||..|||.||||:| :|. :.|
Zfish   481 CYAGWLGPLCNCSAGAS--TDSVMCIERGKTEP----------CSGRGDCMCGTCVCYNPNQFEG 533

  Fly   550 PFC-----ECREC--LDCDEKLADCFCGQCVCKYGWSGSKCNCDGDTDACVGPTGEICSERGTCQ 607
            |:|     :|:..  ..|:|: ..|..|:|||..||||..|.|....|:|....|.||::||.|:
Zfish   534 PYCQFDKSQCQRFGGFLCNER-GSCSMGRCVCSPGWSGEACECPTSNDSCRDSKGGICNDRGVCK 597

  Fly   608 CEECQCEE---PYLGKFCEIDPEKDNKLCLFYEPCVTCLIEQKQGMGVCENLTEICSSLDRQETY 669
            |..|:||.   | |...||.:.::...:|.....||.|     |.....|.....|      :..
Zfish   598 CGRCECEHSGLP-LSPTCEANFQQQVGMCEAKRSCVQC-----QAWSTGERKGRKC------DEC 650

  Fly   670 PYNFVHELDPEQDQCLVRLVNKHGIQCDSFFVYQVIDHSNF-------LTIQAVDCEPPDYVALV 727
            |:..|...:.|:|:.::...:......|..:.|.|...||.       |..:..||.|..::.|:
Zfish   651 PFKIVRVDELEEDKNVIETCSFRDEDDDCTYHYNVNYPSNITDKEHRVLVKKKKDCPPAGFLWLI 715

  Fly   728 GYISAFTLLIGLLII 742
            ..|....||:|||::
Zfish   716 PLIMFLMLLLGLLLL 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Itgbn	NP_001303333.1	INB	38..460	CDD:197563	133/449 (30%)
		EGF_2	524..552	CDD:285248	13/29 (45%)
		Integrin_b_cyt	748..785	CDD:285884
itgb4	XP_005166847.1	Integrin_beta	37..457	CDD:278776	133/449 (30%)
		EGF_2	<468..490	CDD:285248	10/21 (48%)
		EGF_2	545..573	CDD:285248	11/28 (39%)
		Integrin_B_tail	625..709	CDD:285239	19/94 (20%)
		Calx-beta	991..1064	CDD:295344
		FN3	1242..1326	CDD:238020
		FN3	1331..1420	CDD:238020
		fn3	1640..1720	CDD:278470
		fn3	1751..1835	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596173
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1226
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.810