Protein Alignment Itgbn and Itgb8

DIOPT Version :10

• Sequence 1: NP_523608.2
• Gene: Itgbn / 35368
• FlyBaseID: FBgn0010395
• Length: 799
• Species: Drosophila melanogaster
• Sequence 2: NP_796264.2
• Gene: Itgb8 / 320910
• MGIID: 1338035
• Length: 767
• Species: Mus musculus
• Alignment Length: 822
• Identity: 230/822 - (27%)
• Similarity: 358/822 - (43%)
• Gaps: 138/822 - (16%)

  Fly    11 WIY-LVFLIAEISHSDADSIDDQCRHAD--SCERCLSAHLECAWCTDKEYQVG----YRCLSRRQ 68
            |:: ||..:.:..|       ::|..|:  ||.|||....||.||..:::..|    .||.:...
Mouse    31 WVFSLVLGLGQSEH-------NRCGSANVVSCARCLQLGPECGWCVQEDFVSGGSGSERCDTVSS 88

  Fly    69 LLNYNCSETDIYENQPVLDVLQDKPLKDYETSDQAV--QVTPQRAYLKLVKGNTQRMKLSYRTAR 131
            |::..|         || |.::...:....:|:..:  ||||....::|..|......|..|..:
Mouse    89 LISKGC---------PV-DSIEYLSVHVVTSSENEINTQVTPGEVSVQLHPGAEANFMLKVRPLK 143

  Fly   132 NNPLDLYVLMDLTWTMRDDKKTLEELGAQLSQTLKNLTGNYRLGFGSFADKPTLPMIL--PQHRE 194
            ..|:|||.|:|::.:|.::.:.|..:|..||:.:...:.::||||||:.||...|.|.  |:...
Mouse   144 KYPVDLYYLVDVSASMHNNIEKLNSVGNDLSKKMALYSRDFRLGFGSYVDKTVSPYISIHPERIH 208

  Fly   195 NPCAAERATCEPTYGYRHQLSLTDDIPAFTSAVANSKITGNLDNLEGGLDALMQVIVCTKEIGWK 259
            |.|:.....|.|.:||.|.||||::|..|..||...||:||:|..|||.||::|..||...|||:
Mouse   209 NQCSDYNLDCMPPHGYIHVLSLTENITEFEKAVHRQKISGNIDTPEGGFDAMLQAAVCESHIGWR 273

  Fly   260 EQARKVVILVTDGFMHLAGDGLLAGIIQRNDKQCHLNKAGEYTGSLNYDYPSLEEIYRELLRRKI 324
            ::|:::::::||...|||.|..||||:..||..||| |...|..|...::|||.::..:|:...|
Mouse   274 KEAKRLLLVMTDQTSHLALDSKLAGIVVPNDGNCHL-KNNVYVKSTTMEHPSLGQLSEKLIDNNI 337

  Fly   325 NVIFAVTEEVVSSYWELSALMKEISYVDILSADSSNILELIKKSYESLIKRTQF-ADNSPDFIDM 388
            ||||||..:....|.:|..|:.. :....:.:.::|:..|:.::|:.:|...:. .:|....:..
Mouse   338 NVIFAVQGKQFHWYKDLLPLLPG-AIAGEIESKAANLNNLVVEAYKKIISEVKVQLENQVHGVHF 401

  Fly   389 AYYTDC--GGQFPSLQKRNYCNNVTLGKQIDFYVDVTLKKYP----DNQVYTHKIRVEETSLSEF 447
            .....|  |.:.|.:   :.|.|||...::.|.|.|.:|...    .|......|...||:
Mouse   402 NITAICPDGARKPGI---SGCGNVTSNDEVLFNVTVVMKTCDIMGGKNYAIIKPIGFNETT---- 459

  Fly   448 MDLDVELQRPCPCQETPDPENEEGRFLCDYKGYLYCGMCECDEGWTGTYC-NCPTDATNVTSNEA 511
               .|.:.|.|.||    .||..|     .||       :|.|......| .|.....:...::.
Mouse   460 ---KVHIHRSCSCQ----CENHRG-----LKG-------QCAEAAPDPKCPQCDDSRCHFDEDQF 505

  Fly   512 LLQKCRQPFSDKSTSELVCSNHGDCDCGTCLCDP----GYTGPFCECRECLDCDEKLAD------ 566
            ..:.|: |..|:.    |||..|.|.||.|||..    ...|.:|| ::...|.....|
Mouse   506 PSETCK-PQEDQP----VCSGRGVCICGKCLCHKTKLGRVYGQYCE-KDDFSCPYLHGDVCAGHG 564

  Fly   567 -CFCGQCVCKYGWSGSKCNC-DGDTDACVGPTGEICSERGTCQCEECQCEEPYLGKFCEIDPEKD 629
             |..|:|.|..||.|.:|.| ......||...|::||.||||.|..|:|          .||...
Mouse   565 ECEGGRCQCFSGWEGDRCQCPSASAQHCVNSKGQVCSGRGTCVCGRCEC----------TDPRSI 619

  Fly   630 NKLCLFYEPCVTCLIEQKQGMGVCENLTEICSSLDRQETYPYNFVH-ELDPEQDQCLVRLVNKHG 693
            .:||   |.|.||.:...:.....:.|            :|:|... .||..:..|.|  :.:|.
Mouse   620 GRLC---EHCPTCHLSCSENWNCLQCL------------HPHNLSQAALDQCKSSCAV--MEQHR 667

  Fly   694 IQCDSFFVYQVIDHSNFLTIQAVDC-EPPDYVALVGYISAFTLLIGLLIIFIILWYI------RA 751
            :.                  |..:| ..|.|:.:...|...|.|||||.:.||...|      :.
Mouse   668 MD------------------QTSECLSGPSYLRIFFIIFIVTFLIGLLKVLIIRQVILQWNNNKI 714

  Fly   752 KDAREYAKFEEDQKNSVRQENPIYRDPVGRYEVPKALSVKYD 793
            |.:.:| :....:|:.:..::...|....|.|.|:  .:|.|
Mouse   715 KSSSDY-RMSASKKDKLILQSVCTRAVTYRREKPE--EIKMD 753

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Itgbn	NP_523608.2	INB	38..460	CDD:197563	135/436 (31%)
		EGF_2	529..552	CDD:400365	11/26 (42%)
		Integrin_b_cyt	752..785	CDD:462580	6/32 (19%)
Itgb8	NP_796264.2	INB	54..469	CDD:197563	135/436 (31%)