Protein Alignment Itgbn and Itgb6

DIOPT Version :10

• Sequence 1: NP_523608.2
• Gene: Itgbn / 35368
• FlyBaseID: FBgn0010395
• Length: 799
• Species: Drosophila melanogaster
• Sequence 2: NP_001004263.1
• Gene: Itgb6 / 311061
• RGDID: 1303119
• Length: 787
• Species: Rattus norvegicus
• Alignment Length: 806
• Identity: 257/806 - (31%)
• Similarity: 399/806 - (49%)
• Gaps: 83/806 - (10%)

  Fly    27 DSIDDQC--RHADSCERCLSAHLECAWCTDKEYQ----VGYRCLSRRQLLNYNCSETDIYENQPV 85
            |.:...|  ..|::|..||.....||||:.:.:.    .|.||.:...||...| :....|| ||
  Rat    17 DHVQGGCAWSGAETCSDCLLTGPHCAWCSQENFTHLSGAGERCDTPENLLAKGC-QLPFIEN-PV 79

  Fly    86 --LDVLQDKPLK--DYETSDQAVQVTPQRAYLKLVKGNTQRMKLSYRTARNNPLDLYVLMDLTWT 146
              :::||:|||.  ..:.|...||:.||...|||..|..|.:::..|...:.|:|||.||||:.:
  Rat    80 SQVEILQNKPLSVGRQKNSSDIVQIAPQSLVLKLRPGGEQTLQVQVRQTEDYPVDLYYLMDLSAS 144

  Fly   147 MRDDKKTLEELGAQLSQTLKNLTGNYRLGFGSFADKPTLPMI--LPQHRENPCAAERATCEPTYG 209
            |.||..|::|||::|::.:..||.|:|||||||.:||..|.:  .|:...|||::....|.||:|
  Rat   145 MDDDLNTIKELGSRLAKEMSKLTSNFRLGFGSFVEKPVSPFMKTTPEEITNPCSSIPYFCLPTFG 209

  Fly   210 YRHQLSLTDDIPAFTSAVANSKITGNLDNLEGGLDALMQVIVCTKEIGWKEQARKVVILVTDGFM 274
            ::|.|.||||...|...|...||:.|:|..|||.||:||..||.::|||:..:..:::.|:|...
  Rat   210 FKHILPLTDDAERFNEIVRKQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLVFVSDADS 274

  Fly   275 HLAGDGLLAGIIQRNDKQCHLNKAGEYTGSLNYDYPSLEEIYRELLRRKINVIFAVTEEVVSSYW 339
            |...|..||||:..||..|||:...||:.|...:||::.::..:|::..:.:|||||:|.|..|.
  Rat   275 HFGMDSKLAGIVIPNDGLCHLDNRNEYSMSTVLEYPTIGQLIDKLVQNNVLLIFAVTQEQVHLYE 339

  Fly   340 ELSALMKEISYVDILSADSSNILELIKKSYESLIKRTQF-ADNSPDFIDMAYYTDC--GGQFPSL 401
            ..:.|:...: |.:|..||.|||:||..:||.|....:. .....:.:::::...|  |..||..
  Rat   340 NYAKLIPGAT-VGLLQKDSGNILQLIISAYEELRSEVELEVLGDTEGLNLSFTALCSNGILFPHQ 403

  Fly   402 QKRNYCNNVTLGKQIDFYVDVTLKKYPDNQVYTHKIRVEETSLSEFMDLDVELQRPCPCQETPDP 466
            :|   |:::.:|....|.|.|::   .:.:..:.|:.::...|.:.:::.|..:..|.||.
  Rat   404 KK---CSHMKVGDTASFNVSVSI---TNCEKRSRKLIIKPVGLGDTLEILVSAECDCDCQR---- 458

  Fly   467 ENEEGRFLCDY-KGYLYCGMCECDEGWTGTYCNCPTDATNVTSNEALLQKCRQPFSDKSTSELVC 530
            |.|.....|.: .|...||:|.|:.|..|..|.|..|..:..|       |::     |.....|
  Rat   459 EVEANSSKCHHGNGSFQCGVCACNPGHMGPRCECGEDMVSTDS-------CKE-----SPGHPSC 511

  Fly   531 SNHGDCDCGTCLC--DP--GYTGPFCECR--ECLD-----CDEKLADCFCGQCVCKYGWSGSKCN 584
            |..|||.||.|:|  .|  ...||:|:|.  .||.     |.:. .||.||:|||:.||:|..||
  Rat   512 SGRGDCYCGQCVCHLSPYGSIYGPYCQCDNFSCLRHKGLLCGDN-GDCDCGECVCRDGWTGEYCN 575

  Fly   585 CDGDTDACVGPTGEICSERGTCQCEECQCEEP-YLGKFCEIDPEKDNKLCLFYEPCVTC-LIEQK 647
            |....|||....|.:||.||.|.|.:|.|..| ..|..||..|...:. |.....|:.| |....
  Rat   576 CTTSRDACASEDGVLCSGRGDCVCGKCVCRNPGASGPTCERCPTCGDP-CNSRRSCIECYLSADG 639

  Fly   648 QGMGVCENLTEICSSLDRQETY------PYNFVHELDPEQDQCLVRLVNKHGIQCDSFFVYQVID 706
            |....||:..:...:...:|.:      |.:...|     ::||:..:    |..|:  ..:.|.
  Rat   640 QAQEECEDKCKATGATISEEEFSKDTSVPCSLQGE-----NECLITFL----ITADN--EGKTII 693

  Fly   707 HSNFLTIQAVDC-EPPDYVALVGYISAFTLLIGLLIIFIILWYIRAKDAREYAKFEEDQKNSVRQ 770
            |:    |...|| :||:...::..:|...||||::::.|....:...|.:|.||||.::..:..|
  Rat   694 HN----ISEKDCPKPPNIPMIMLGVSLAILLIGVVLLCIWKLLVSFHDRKEVAKFEAERSKAKWQ 754

  Fly   771 --ENPIYRDPVGRYEVPKALSVKYDE 794
              .||:||.....:   |.::.|:.|
  Rat   755 TGTNPLYRGSTSTF---KNVTYKHRE 777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Itgbn	NP_523608.2	INB	38..460	CDD:197563	148/434 (34%)
		EGF_2	529..552	CDD:400365	12/26 (46%)
		Integrin_b_cyt	752..785	CDD:462580	11/34 (32%)
Itgb6	NP_001004263.1	INB	30..454	CDD:197563	147/432 (34%)
		I-EGF_1	456..485	CDD:465729	10/32 (31%)
		Integrin_B_tail	624..705	CDD:462325	19/95 (20%)
		Interaction with HAX1. /evidence=ECO:0000250|UniProtKB:P18564	730..757		7/26 (27%)
		Integrin_b_cyt	733..773	CDD:462580	12/42 (29%)