DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Itgbn and Itgb6

DIOPT Version :9

Sequence 1:	NP_001303333.1	Gene:	Itgbn / 35368	FlyBaseID:	FBgn0010395	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	NP_001004263.1	Gene:	Itgb6 / 311061	RGDID:	1303119	Length:	787	Species:	Rattus norvegicus

Alignment Length:	806	Identity:	257/806 - (31%)
Similarity:	399/806 - (49%)	Gaps:	83/806 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 DSIDDQC--RHADSCERCLSAHLECAWCTDKEYQ----VGYRCLSRRQLLNYNCSETDIYENQPV 85
            |.:...|  ..|::|..||.....||||:.:.:.    .|.||.:...||...| :....|| ||
  Rat    17 DHVQGGCAWSGAETCSDCLLTGPHCAWCSQENFTHLSGAGERCDTPENLLAKGC-QLPFIEN-PV 79

  Fly    86 --LDVLQDKPLK--DYETSDQAVQVTPQRAYLKLVKGNTQRMKLSYRTARNNPLDLYVLMDLTWT 146
              :::||:|||.  ..:.|...||:.||...|||..|..|.:::..|...:.|:|||.||||:.:
  Rat    80 SQVEILQNKPLSVGRQKNSSDIVQIAPQSLVLKLRPGGEQTLQVQVRQTEDYPVDLYYLMDLSAS 144

  Fly   147 MRDDKKTLEELGAQLSQTLKNLTGNYRLGFGSFADKPTLPMI--LPQHRENPCAAERATCEPTYG 209
            |.||..|::|||::|::.:..||.|:|||||||.:||..|.:  .|:...|||::....|.||:|
  Rat   145 MDDDLNTIKELGSRLAKEMSKLTSNFRLGFGSFVEKPVSPFMKTTPEEITNPCSSIPYFCLPTFG 209

  Fly   210 YRHQLSLTDDIPAFTSAVANSKITGNLDNLEGGLDALMQVIVCTKEIGWKEQARKVVILVTDGFM 274
            ::|.|.||||...|...|...||:.|:|..|||.||:||..||.::|||:..:..:::.|:|...
  Rat   210 FKHILPLTDDAERFNEIVRKQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLVFVSDADS 274

  Fly   275 HLAGDGLLAGIIQRNDKQCHLNKAGEYTGSLNYDYPSLEEIYRELLRRKINVIFAVTEEVVSSYW 339
            |...|..||||:..||..|||:...||:.|...:||::.::..:|::..:.:|||||:|.|..|.
  Rat   275 HFGMDSKLAGIVIPNDGLCHLDNRNEYSMSTVLEYPTIGQLIDKLVQNNVLLIFAVTQEQVHLYE 339

  Fly   340 ELSALMKEISYVDILSADSSNILELIKKSYESLIKRTQF-ADNSPDFIDMAYYTDC--GGQFPSL 401
            ..:.|:...: |.:|..||.|||:||..:||.|....:. .....:.:::::...|  |..||..
  Rat   340 NYAKLIPGAT-VGLLQKDSGNILQLIISAYEELRSEVELEVLGDTEGLNLSFTALCSNGILFPHQ 403

  Fly   402 QKRNYCNNVTLGKQIDFYVDVTLKKYPDNQVYTHKIRVEETSLSEFMDLDVELQRPCPCQETPDP 466
            :|   |:::.:|....|.|.|::   .:.:..:.|:.::...|.:.:::.|..:..|.||.
  Rat   404 KK---CSHMKVGDTASFNVSVSI---TNCEKRSRKLIIKPVGLGDTLEILVSAECDCDCQR---- 458

  Fly   467 ENEEGRFLCDY-KGYLYCGMCECDEGWTGTYCNCPTDATNVTSNEALLQKCRQPFSDKSTSELVC 530
            |.|.....|.: .|...||:|.|:.|..|..|.|..|..:..|       |::     |.....|
  Rat   459 EVEANSSKCHHGNGSFQCGVCACNPGHMGPRCECGEDMVSTDS-------CKE-----SPGHPSC 511

  Fly   531 SNHGDCDCGTCLC--DP--GYTGPFCECR--ECLD-----CDEKLADCFCGQCVCKYGWSGSKCN 584
            |..|||.||.|:|  .|  ...||:|:|.  .||.     |.:. .||.||:|||:.||:|..||
  Rat   512 SGRGDCYCGQCVCHLSPYGSIYGPYCQCDNFSCLRHKGLLCGDN-GDCDCGECVCRDGWTGEYCN 575

  Fly   585 CDGDTDACVGPTGEICSERGTCQCEECQCEEP-YLGKFCEIDPEKDNKLCLFYEPCVTC-LIEQK 647
            |....|||....|.:||.||.|.|.:|.|..| ..|..||..|...:. |.....|:.| |....
  Rat   576 CTTSRDACASEDGVLCSGRGDCVCGKCVCRNPGASGPTCERCPTCGDP-CNSRRSCIECYLSADG 639

  Fly   648 QGMGVCENLTEICSSLDRQETY------PYNFVHELDPEQDQCLVRLVNKHGIQCDSFFVYQVID 706
            |....||:..:...:...:|.:      |.:...|     ::||:..:    |..|:  ..:.|.
  Rat   640 QAQEECEDKCKATGATISEEEFSKDTSVPCSLQGE-----NECLITFL----ITADN--EGKTII 693

  Fly   707 HSNFLTIQAVDC-EPPDYVALVGYISAFTLLIGLLIIFIILWYIRAKDAREYAKFEEDQKNSVRQ 770
            |:    |...|| :||:...::..:|...||||::::.|....:...|.:|.||||.::..:..|
  Rat   694 HN----ISEKDCPKPPNIPMIMLGVSLAILLIGVVLLCIWKLLVSFHDRKEVAKFEAERSKAKWQ 754

  Fly   771 --ENPIYRDPVGRYEVPKALSVKYDE 794
              .||:||.....:   |.::.|:.|
  Rat   755 TGTNPLYRGSTSTF---KNVTYKHRE 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Itgbn	NP_001303333.1	INB	38..460	CDD:197563	148/434 (34%)
		EGF_2	524..552	CDD:285248	13/31 (42%)
		Integrin_b_cyt	748..785	CDD:285884	11/38 (29%)
Itgb6	NP_001004263.1	Integrin_beta	30..454	CDD:278776	147/432 (34%)
		Cysteine-rich tandem repeats	456..619		64/179 (36%)
		Integrin_B_tail	624..705	CDD:285239	19/95 (20%)
		Interaction with HAX1. /evidence=ECO:0000250	730..757		7/26 (27%)
		Integrin_b_cyt	732..774	CDD:285884	12/44 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353965
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1226
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100678
Panther	1	1.100	-	-	O	PTHR10082
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750