DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Itgbn and Itgb5

DIOPT Version :9

Sequence 1:	NP_001303333.1	Gene:	Itgbn / 35368	FlyBaseID:	FBgn0010395	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	NP_671480.2	Gene:	Itgb5 / 257645	RGDID:	628869	Length:	799	Species:	Rattus norvegicus

Alignment Length:	794	Identity:	253/794 - (31%)
Similarity:	390/794 - (49%)	Gaps:	67/794 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 ADSCERCLSAHLECAWCTDKEY-----QVGYRCLSRRQLLNYNCSETDIYENQPVLDVLQDKPLK 95
            |.|||.||..|.:||||: |||     .:..||..:..|:...|. .:|........||::.||.
  Rat    33 ATSCEECLLIHPKCAWCS-KEYFGNPRSIISRCDLKANLIRNGCG-GEIESPASSTHVLRNLPLS 95

  Fly    96 DYETS---DQAVQVTPQRAYLKLVKGNTQRMKLSYRTARNNPLDLYVLMDLTWTMRDDKKTLEEL 157
            ...:|   ...:|:|||...:.|..|:....:|..|...:.|:|||.||||:.:|:||...:..|
  Rat    96 SKGSSAMGSDVIQMTPQEIAVSLRPGDQATFQLQVRQVEDYPVDLYYLMDLSLSMKDDLDNIRSL 160

  Fly   158 GAQLSQTLKNLTGNYRLGFGSFADKPTLPM--ILPQHRENPCAAER--ATCEPTYGYRHQLSLTD 218
            |.:|::.::.||.|:|||||||.||...|.  ..|:::.|||...:  ..|.|::|:||.|.|||
  Rat   161 GTKLAEEMRKLTSNFRLGFGSFVDKDISPFSYTAPRYQTNPCIGYKLFPNCVPSFGFRHLLPLTD 225

  Fly   219 DIPAFTSAVANSKITGNLDNLEGGLDALMQVIVCTKEIGWKEQARKVVILVTDGFMHLAGDGLLA 283
            .:.:|...|...:::.|.|..|||.||::|..||.::|||::.|..:::..||...|:|.||.|.
  Rat   226 RVDSFNEEVRKQRVSRNRDAPEGGFDAVLQAAVCKEKIGWRKDALHLLVFTTDDVPHIALDGKLG 290

  Fly   284 GIIQRNDKQCHLNKAGEYTGSLNYDYPSLEEIYRELLRRKINVIFAVTEEVVSSYWELSALMKEI 348
            |::|.:|.|||||:|.|||.|...|||||..:..:|....||:|||||:.....|...:||:...
  Rat   291 GLVQPHDGQCHLNEANEYTASDQMDYPSLALLGEKLAENNINLIFAVTKNHYMLYKNFTALIPGT 355

  Fly   349 SYVDILSADSSNILELIKKSYESLIKRTQFAD-NSPDFIDMAYYTDC--GGQFPSLQKRNYCNNV 410
            : |:||..||.||::||..:|.|:..:.:.:. :.|:.:::.:...|  |..:|..:|   |..:
  Rat   356 T-VEILHGDSKNIIQLIINAYSSIRAKVELSVWDQPEDLNLFFTATCQDGLSYPGQRK---CEGL 416

  Fly   411 TLGKQIDFYVDVTLKKYPDNQVYTHKIRVEETSLSEFMDLDVELQRPCPCQETPDPENEEGRFLC 475
            .:|....|.|.|..:..|.... |....:......:.:.::|.....|.|....:|.:..    |
  Rat   417 KIGDTASFEVSVEARSCPGRHT-TQSFTLRPVGFRDSLQVEVAYNCTCGCSAGLEPNSAR----C 476

  Fly   476 DYKGYLYCGMCECDEGWTGTYCNCPTDATNVTSNEALLQKCRQPFSDKSTSELVCSNHGDCDCGT 540
            ...|...||:||||..:.||.|.| .:..|.:..:.|   ||:     :..:.:||..|:|.|..
  Rat   477 SGNGTYVCGLCECDPSYLGTRCEC-QEGENQSGYQNL---CRE-----AEGKPLCSGRGECSCNQ 532

  Fly   541 CLCDPG----YTGPFCECRECLDCDEKL-------ADCFCGQCVCKYGWSGSKCNCDGDTDACVG 594
            |.|...    ..|||||| :...|....       .:|.||:|.|..|:.|..|||..|...|..
  Rat   533 CSCFESEFGRIYGPFCEC-DSFSCARNKGVLCSGHGECHCGECKCHVGYIGDNCNCSTDISTCRA 596

  Fly   595 PTGEICSERGTCQCEECQCEEP-YLGKFCEIDPEKDNKLCLFYEPCVTC-LIEQKQGMGVCENLT 657
            ..|:|||:||.|.|.:|||.|| ..|:.||..|...: .|.....||.| |:.|    |..:|.|
  Rat   597 KDGQICSDRGRCVCGQCQCTEPGAFGETCEKCPTCPD-ACSSKRDCVECSLLHQ----GKPDNQT 656

  Fly   658 EICSSLDRQETYPYNFVHELDPEQDQCLVRLVNKHGIQCDSFFVYQVIDH--SNFLTIQAVDC-E 719
            ......|...|:..:.|     :.||..|....|....|...|.|..:.:  ||...::..:| .
  Rat   657 CHHQCKDEVITWVDSIV-----KDDQEAVLCFYKTAKDCVMMFSYTELPNGKSNLTVLREPECGS 716

  Fly   720 PPDYVALVGYISAFTLLIGLLIIFIILWYIRAKDAREYAKFEEDQKNSVRQE---NPIYRDPVGR 781
            .|:.:.::..:....||:|:.::.|....:...|.||:||| :.:::..|.|   ||:||.|:..
  Rat   717 APNAMTILLAVVGSILLVGMALLAIWKLLVTIHDRREFAKF-QSERSRARYEMASNPLYRKPIST 780

  Fly   782 YEVPKALSVKYDEN 795
            :.|..|.: |::::
  Rat   781 HTVDFAFN-KFNKS 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Itgbn	NP_001303333.1	INB	38..460	CDD:197563	148/436 (34%)
		EGF_2	524..552	CDD:285248	9/31 (29%)
		Integrin_b_cyt	748..785	CDD:285884	13/39 (33%)
Itgb5	NP_671480.2	INB	35..463	CDD:197563	147/434 (34%)
		I-EGF_1	465..493	CDD:408172	10/31 (32%)
		exchanger_TraA	<479..>644	CDD:411343	61/175 (35%)
		Integrin_B_tail	635..718	CDD:400356	22/91 (24%)
		Integrin_b_cyt	743..781	CDD:400871	13/38 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010