Protein Alignment Itgbn and Itgb4

DIOPT Version :10

• Sequence 1: NP_523608.2
• Gene: Itgbn / 35368
• FlyBaseID: FBgn0010395
• Length: 799
• Species: Drosophila melanogaster
• Sequence 2: XP_038941223.1
• Gene: Itgb4 / 25724
• RGDID: 2928
• Length: 1872
• Species: Rattus norvegicus
• Alignment Length: 788
• Identity: 222/788 - (28%)
• Similarity: 364/788 - (46%)
• Gaps: 118/788 - (14%)

  Fly    11 WIYLVFLIAEISHSDADSIDDQCRHAD--SCERCLSAHLECAWCTDKEYQVGYRCLSRRQLLNYN 73
            |:.|:..:. :|.....::.::|:.|.  ||..|:.....||:|||:.:: ..||.::.:||...
  Rat     9 WVKLLLAVV-LSAGLPGNMANRCKKAQVKSCTECIRVDKSCAYCTDELFK-ERRCNTQAELLAAG 71

  Fly    74 CSETDIYENQPVLDVLQDKPLKDYETSDQAVQVTPQRAYLKLVKGNTQRMKLSYRTARNNPLDLY 138
            |....:...:..|::.::..:   :||....||:||...::|..|..:...........:|:|||
  Rat    72 CRGESVLVMESSLEITENIQI---DTSLHRSQVSPQGLQVRLRPGEERNFVFKVFEPLESPVDLY 133

  Fly   139 VLMDLTWTMRDDKKTLEELGAQLSQTLKNLTGNYRLGFGSFADKPTLPM--ILPQHRENPCAAER 201
            :|||.:.:|.||...|:::|..|::.|:.||.:|.:|||.|.||.::|.  :.|:..:.|.
  Rat   134 ILMDFSNSMSDDLDNLKQMGQNLAKILRQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPW---- 194

  Fly   202 ATCEPTYGYRHQLSLTDDIPAFTSAVANSKITGNLDNLEGGLDALMQVIVCTKEIGWKEQARKVV 266
            ...:|.:.:::.:|||:::..|...:...:|:||||..|||.||::|..|||::|||:..:..::
  Rat   195 PNSDPPFSFKNVISLTENVEEFWDKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRADSTHLL 259

  Fly   267 ILVTDGFMHLAGDG--LLAGIIQRNDKQCHLNKAGEYTGSLNYDYPSLEEIYRELLRRKINVIFA 329
            :..|:...|...||  :||||:.|||::|||:..|.||.....||||:..:.|.|.:..|..|||
  Rat   260 VFSTESAFHYEADGANVLAGIMNRNDEKCHLDATGAYTQYKTQDYPSVPTLVRLLAKHNIIPIFA 324

  Fly   330 VTEEVVSSYWELSALMKEISYVDILSADSSNILELIKKSYESLIKRTQF-ADNSPDFIDMAYYTD 393
            ||....|.|.:|.... .:|.:.:|..|||||:||:::::..:...... |.:||..:.....:|
  Rat   325 VTNYSYSYYEKLHKYF-PVSSLGVLQEDSSNIVELLEEAFYRIRSNLDIRALDSPRGLRTEVTSD 388

  Fly   394 CGGQFPSLQKRNYCNNVTLGKQIDFYVDVTLKKYPDNQVYTHKIRVE----------ETSLSEFM 448
                  :|||....:......::..| :|.|:...|.. .||..::.          :.|.|:.:
  Rat   389 ------TLQKTETGSFHIKRGEVGTY-NVHLRAVEDID-GTHVCQMAKEDQRGNIHLKPSFSDGL 445

  Fly   449 DLDVE-LQRPCPCQETPDPENEEGRFLCDYKGYLYCGMCECDEGWTGTYCNCPTDATNVTSNEAL 512
            .:|.. :...|.|:...:.::..    |.|:|...||.|.|:|||:|..|||.|.:.:.|
  Rat   446 RMDASVICDVCACELQKEVQSAR----CHYRGDFMCGHCVCNEGWSGKTCNCSTGSLSDT----- 501

  Fly   513 LQKCRQPFSDKSTSELVCSNHGDCDCGTCLC--DPGYTGPFCECR--EC-----LDCDEKLADCF 568
             |.|.:...||.     ||.||:|.||.|:|  :..|.|.|||..  :|     ..|::: ..|.
  Rat   502 -QPCLREGEDKP-----CSGHGECQCGRCVCYGEGRYEGHFCEYDNFQCPRTSGFLCNDR-GRCS 559

  Fly   569 CGQCVCKYGWSGSKCNCDGDTDACVGPTGEICSERGTCQCEECQCEEP---YLGKFCEIDPEKDN 630
            .|:|||:.||:|..|:|......|:...|.||:..|.|:|..|.|.:.   |....|||:.....
  Rat   560 MGECVCEPGWTGRSCDCPLSNATCIDSNGGICNGLGFCECGRCHCNQRSSLYTDTTCEINYSAIR 624

  Fly   631 -KLCLFYEPCVTCLIEQKQGMG-----VC----------------ENLTEICSSLDRQETYPYNF 673
             .||.....||.|   |..|.|     .|                |.:.|.||..|..:...|::
  Rat   625 LGLCEDLRSCVQC---QAWGTGEKKGRTCEECNFKVKMVDELKKAEEVVEYCSFRDEDDDCTYSY 686

  Fly   674 VHELDPEQDQCLVRLVNKHGIQCDSFFVYQVIDHSNFLTIQAVDCEPPDYVALVGYISAFTLLIG 738
            ..|.|....                       .:|..|..:..||.|..:..|:      .|||.
  Rat   687 TVEGDGSPG-----------------------PNSTVLVHKKKDCPPGSFWWLI------PLLIF 722

  Fly   739 LLIIFIIL 746
            ||::.::|
  Rat   723 LLLLLVLL 730

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Itgbn	NP_523608.2	INB	38..460	CDD:197563	128/437 (29%)
		EGF_2	529..552	CDD:400365	11/24 (46%)
		Integrin_b_cyt	752..785	CDD:462580
Itgb4	XP_038941223.1	vWFA	37..454	CDD:469594	127/433 (29%)
		I-EGF_1	458..486	CDD:465729	9/31 (29%)
		Integrin_B_tail	628..711	CDD:462325	20/108 (19%)
		Calx_beta	992..1086	CDD:197594
		fn3	1130..1210	CDD:394996
		FN3	1222..1315	CDD:238020
		FN3	1577..1658	CDD:238020
		fn3	1691..1776	CDD:394996