DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Itgbn and Itgb1

DIOPT Version :9

Sequence 1:	NP_001303333.1	Gene:	Itgbn / 35368	FlyBaseID:	FBgn0010395	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	XP_006255886.1	Gene:	Itgb1 / 24511	RGDID:	2927	Length:	801	Species:	Rattus norvegicus

Alignment Length:	840	Identity:	272/840 - (32%)
Similarity:	411/840 - (48%)	Gaps:	119/840 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 WIYLVFLIAEI-SHSDADSIDDQC--RHADSCERCLSAHLECAWCTDKEY-QVGY----RCLSRR 67
            ||.|:.||..: ..:|    .::|  .:|.||..|:.|...|.|||:..: |.|.    ||....
  Rat     8 WIGLISLICSVFGQTD----KNRCLKANAKSCGECIQAGPNCGWCTNTTFLQEGMPTSARCDDLE 68

  Fly    68 QLLNYNCSETD---------IYENQPVLDVLQDKPLKDYETSDQAVQVTPQRAYLKLVKGNTQRM 123
            .|....|..:|         |.:|:.|.:  :.|.:.:....:...|:.||:..|||..|..|:.
  Rat    69 ALKKKGCQPSDIENPRGSQTIKKNKNVTN--RSKGMAEKLRPEDITQIQPQQLLLKLRSGEPQKF 131

  Fly   124 KLSYRTARNNPLDLYVLMDLTWTMRDDKKTLEELGAQLSQTLKNLTGNYRLGFGSFADKPTLPMI 188
            .|.::.|.:.|:|||.||||:::|:||.:.::.||..|...::.:|.::|:|||||.:|..:|.|
  Rat   132 TLKFKRAEDYPIDLYYLMDLSYSMKDDLENVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYI 196

  Fly   189 --LPQHRENPCAAERATCEPTYGYRHQLSLTDDIPAFTSAVANSKITGNLDNLEGGLDALMQVIV 251
              .|....|||.:|: .|...:.|::.|||||....|...|...:|:||||:.|||.||:|||.|
  Rat   197 STTPAKLRNPCTSEQ-NCTSPFSYKNVLSLTDRGEFFNELVGQQRISGNLDSPEGGFDAIMQVAV 260

  Fly   252 CTKEIGWKEQARKVVILVTDGFMHLAGDGLLAGIIQRNDKQCHLNKAGEYTGSLNYDYPSLEEIY 316
            |...|||:...| :::..||...|.||||.|.||:..||.||||.. ..||.|..|||||:..:.
  Rat   261 CGSLIGWRNVTR-LLVFSTDAGFHFAGDGKLGGIVLPNDGQCHLEN-NVYTMSHYYDYPSIAHLV 323

  Fly   317 RELLRRKINVIFAVTEEVVSSYWELSALMKEISYVDILSADSSNILELIKKSYESLIKRTQFADN 381
            ::|....|..|||||||....|.||..|:.: |.|..||.:|||:::||..:|.||.... ..:|
  Rat   324 QKLSENNIQTIFAVTEEFQPVYKELKNLIPK-SAVGTLSGNSSNVIQLIIDAYNSLSSEV-ILEN 386

  Fly   382 S--PDFIDMAYYTDC-GGQFPSLQKRNYCNNVTLGKQIDFYVDVTLKKYPDNQVYTHKIRVEETS 443
            |  ||.:.:.|.:.| .|...:.:....|:|:::|.::.|.:.:|..|.|:.:..|  |:::...
  Rat   387 SKLPDGVTINYKSYCKNGVNGTGENGRKCSNISIGDEVQFEISITANKCPNKESET--IKIKPLG 449

  Fly   444 LSEFMDLDVELQRPCPCQE---TPDPENEEGRFLCDYKGYLYCGMCECDEGWTGTYCNCPTDATN 505
            .:|.:::.::....|.||.   ...|:..||      .|...||.|.|:||..|.:|.|.||..|
  Rat   450 FTEEVEVVLQFICKCNCQSHGIPASPKCHEG------NGTFECGACRCNEGRVGRHCECSTDEVN 508

  Fly   506 VTSNEALLQKCRQPFSDKSTSELVCSNHGDCDCGTCLC------DPGYTGPFCECRECLDCDEK- 563
            ....:|.   ||     |..|..:|||:|:|.||.|:|      :..|:|.|||| :..:||..
  Rat   509 SEDMDAY---CR-----KENSSEICSNNGECVCGQCVCRKRENTNEIYSGKFCEC-DNFNCDRSN 564

  Fly   564 ------LADCFCGQCVCKYGWSGSKCNCDGDTDACVGPTGEICSERGTCQCEECQCEEP-YLGKF 621
                  ...|.|..|.|...::||.|:|..||..||...|:||:.||.|:|..|:|.:| :.|..
  Rat   565 GLICGGNGVCRCRVCECYPNYTGSACDCSLDTVPCVATNGQICNGRGICECGACKCTDPKFQGPT 629

  Fly   622 CEIDPEKDNKLCLFYEPCVTCLIEQKQGMGVCENLTEI--CSSLDR--------QETYPYNFVH- 675
            |              |.|.|||       |||....|.  |.:.::        ||...:|...
  Rat   630 C--------------ETCQTCL-------GVCAEHKECVQCRAFNKGEKKDTCAQECSHFNLTKV 673

  Fly   676 ----------ELDPEQDQCLVRLVNKHGIQCDSFFVYQVIDH--SNFLTIQAVDCEP-PDYVALV 727
                      ::||     :.....|....|..:|.|.|..:  ::...::..||.. ||.:.:|
  Rat   674 ESREKLPQPVQVDP-----VTHCKEKDIDDCWFYFTYSVNSNGEAHVHVVETPDCPTGPDIIPIV 733

  Fly   728 GYISAFTLLIGLLIIFIILWYIRAKDAREYAKFEEDQKNSV--RQENPIYRDPVGRYEVP 785
            ..:.|..:||||.::.|....:...|.||:||||:::.|:.  .||||||:.|:..::.|
  Rat   734 AGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTQENPIYKSPINNFKNP 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Itgbn	NP_001303333.1	INB	38..460	CDD:197563	153/440 (35%)
		EGF_2	524..552	CDD:285248	12/33 (36%)
		Integrin_b_cyt	748..785	CDD:285884	15/38 (39%)
Itgb1	XP_006255886.1	Integrin_beta	34..464	CDD:278776	152/438 (35%)
		Integrin_B_tail	640..727	CDD:285239	15/91 (16%)
		Integrin_b_cyt	757..796	CDD:285884	16/37 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1226
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100678
Panther	1	1.100	-	-	O	PTHR10082
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.780