DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Itgbn and Itgb3

DIOPT Version :9

Sequence 1:	NP_001303333.1	Gene:	Itgbn / 35368	FlyBaseID:	FBgn0010395	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	NP_058060.2	Gene:	Itgb3 / 16416	MGIID:	96612	Length:	787	Species:	Mus musculus

Alignment Length:	810	Identity:	258/810 - (31%)
Similarity:	392/810 - (48%)	Gaps:	76/810 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LWIYLVFLIAEISHSDADSIDDQCRHADSCERCLSAHLECAWCTDKEYQVGY-RCLSRRQLLNYN 73
            ||..|:.|.|.......:|.....|..:||::||:....||||:|:....|. ||..:..||..|
Mouse     9 LWAALLALGALAGVVVGESNICTTRGVNSCQQCLAVSPVCAWCSDETLSQGSPRCNLKENLLKDN 73

  Fly    74 CSETDIYENQPVLDVLQDKPL--KDYETSDQAVQVTPQRAYLKLVKGNTQRMKLSYRTARNNPLD 136
            |:...|........:|:.:||  |...:|.|..||:|||..|:|...:::...|..|...:.|:|
Mouse    74 CAPESIEFPVSEAQILEARPLSSKGSGSSAQITQVSPQRIALRLRPDDSKIFSLQVRQVEDYPVD 138

  Fly   137 LYVLMDLTWTMRDDKKTLEELGAQLSQTLKNLTGNYRLGFGSFADKPTLPMIL---PQHRENPCA 198
            :|.||||:::|:||..:::.||.:|:..::.||.|.|:|||:|.|||..|.:.   ||..:|||.
Mouse   139 IYYLMDLSFSMKDDLSSIQTLGTKLASQMRKLTSNLRIGFGAFVDKPVSPYMYISPPQAIKNPCY 203

  Fly   199 AERATCEPTYGYRHQLSLTDDIPAFTSAVANSKITGNLDNLEGGLDALMQVIVCTKEIGWKEQAR 263
            ..:..|.|.:||:|.|:|||.:..|...|....::.|.|..|||.||:||..||.::|||:..|.
Mouse   204 NMKNACLPMFGYKHVLTLTDQVSRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDAS 268

  Fly   264 KVVILVTDGFMHLAGDGLLAGIIQRNDKQCHLNKAGEYTGSLNYDYPSLEEIYRELLRRKINVIF 328
            .:::..||...|:|.||.||||:..||..||:.....|:.|...|||||..:..:|.::.||:||
Mouse   269 HLLVFTTDAKTHIALDGRLAGIVLPNDGHCHIGTDNHYSASTTMDYPSLGLMTEKLSQKNINLIF 333

  Fly   329 AVTEEVVSSYWELSALMKEISYVDILSADSSNILELIKKSYESLIKRTQF-ADNSPDFIDMAYYT 392
            ||||.|||.|...|.|:...: |.:||.||||:|:||..:|..:..:.:. ..:.|:.:.:::..
Mouse   334 AVTENVVSLYQNYSELIPGTT-VGVLSDDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNA 397

  Fly   393 DC--GGQFPSLQKRNYCNNVTLGKQIDFYVDVTLKKYPD--NQVYTHKIRVEETSLSEFMDLDVE 453
            .|  ....|.|:.   |..:.:|..:.|.::..::..|.  .|.:|    ::.....:.:.:.|.
Mouse   398 TCLNNEVIPGLKS---CVGLKIGDTVSFSIEAKVRGCPQEKEQSFT----IKPVGFKDSLTVQVT 455

  Fly   454 LQRPCPCQETPDPENEEGRFLCDY-KGYLYCGMCECDEGWTGTYCNCPTDATNVTSNEALLQKCR 517
            ....|.||....|.:..    |:. .|...||:|.||:||.|:.|.|..:....:..|....|..
Mouse   456 FDCDCACQAFAQPSSPR----CNNGNGTFECGVCRCDQGWLGSMCECSEEDYRPSQQEECSPKEG 516

  Fly   518 QPFSDKSTSELVCSNHGDCDCGTCLC---DPG-YTGPFCECRE--CLDCDEKL----ADCFCGQC 572
            ||         :||..|:|.||.|:|   |.| .||.:|||.:  |:....::    ..|.||.|
Mouse   517 QP---------ICSQRGECLCGQCVCHSSDFGKITGKYCECDDFSCVRYKGEMCSGHGQCNCGDC 572

  Fly   573 VCKYGWSGSKCNCDGDTDACVGPTGEICSERGTCQCEECQCEEP-YLGKFCEIDPEKDNKLCLFY 636
            ||...|:|..|||...||.|:...|.:||.||.|:|..|.|.:| ..|..||..|...: .|.|.
Mouse   573 VCDSDWTGYYCNCTTRTDTCMSTNGLLCSGRGNCECGSCVCVQPGSYGDTCEKCPTCPD-ACSFK 636

  Fly   637 EPCVTC-------LIEQKQGMGVCENLTEICSSLDRQETYPYNFVHELDPEQDQCLVRLVNKHGI 694
            :.||.|       |.|:......|.:..|....|........|..::   .:|.|:||
Mouse   637 KECVECKKFNRGTLHEENTCSRYCRDDIEQVKELTDTGKNAVNCTYK---NEDDCVVR------- 691

  Fly   695 QCDSFFVYQVIDHSNFLTIQAVDCEP-----PDYVALVGYISAFTLLIGLLIIFIILWYIRAKDA 754
                |..|:  |.|....:..|: ||     ||.:.::..:....|||||..:.|....|...|.
Mouse   692 ----FQYYE--DTSGRAVLYVVE-EPECPKGPDILVVLLSVMGAILLIGLATLLIWKLLITIHDR 749

  Fly   755 REYAKFEEDQKNSV--RQENPIYRDPVGRY 782
            :|:|||||::..:.  ...||:|::....:
Mouse   750 KEFAKFEEERARAKWDTANNPLYKEATSTF 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Itgbn	NP_001303333.1	INB	38..460	CDD:197563	147/432 (34%)
		EGF_2	524..552	CDD:285248	12/31 (39%)
		Integrin_b_cyt	748..785	CDD:285884	11/37 (30%)
Itgb3	NP_058060.2	Integrin_beta	37..460	CDD:278776	146/430 (34%)
		CX3CL1-binding. /evidence=ECO:0000250\|UniProtKB:P05106	202..209		1/6 (17%)
		Involved in CX3CL1-, NRG1-, FGF1-and IGF1-binding. /evidence=ECO:0000250\|UniProtKB:P05106	202..209		1/6 (17%)
		CX3CL1-binding. /evidence=ECO:0000250\|UniProtKB:P05106	292..312		6/19 (32%)
		Cysteine-rich tandem repeats	462..628		62/178 (35%)
		Integrin_B_tail	633..716	CDD:285239	22/99 (22%)
		Integrin_b_cyt	743..785	CDD:285884	11/37 (30%)
		LIR. /evidence=ECO:0000250\|UniProtKB:P05106	776..782		0/4 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850267
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1226
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100678
Panther	1	1.100	-	-	O	PTHR10082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750