DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Itgbn and Itgb2

DIOPT Version :9

Sequence 1:	NP_001303333.1	Gene:	Itgbn / 35368	FlyBaseID:	FBgn0010395	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	NP_032430.2	Gene:	Itgb2 / 16414	MGIID:	96611	Length:	770	Species:	Mus musculus

Alignment Length:	824	Identity:	262/824 - (31%)
Similarity:	393/824 - (47%)	Gaps:	103/824 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTSLGGRAFLWIYLVFLIAEISHSDADSIDDQCR--HADSCERCLSAHLECAWC-----TDKEYQ 58
            :.:|.|..||               ..::..:|.  ...||..|:.:...|:||     |.....
Mouse     8 LLALAGLFFL---------------GSAVSQECTKYKVSSCRDCIQSGPGCSWCQKLNFTGPGEP 57

  Fly    59 VGYRCLSRRQLLNYNCSETDIYENQPVLDVLQDKPLKDYETSDQAVQVTPQRAYLKLVKGNTQRM 123
            ...||.:|.|||...|...||.:.:.:.:       .:::...|..|::||:..|.|..|.....
Mouse    58 DSLRCDTRAQLLLKGCPADDIMDPRSIAN-------PEFDQRGQRKQLSPQKVTLYLRPGQAAAF 115

  Fly   124 KLSYRTARNNPLDLYVLMDLTWTMRDDKKTLEELGAQLSQTLKNLTGNYRLGFGSFADKPTLPMI 188
            .:::|.|:..|:|||.||||:::|.||...:::||..|.|.|..:|.:.|:|||||.||..||.:
Mouse   116 NVTFRRAKGYPIDLYYLMDLSYSMLDDLNNVKKLGGDLLQALNEITESGRIGFGSFVDKTVLPFV 180

  Fly   189 --LPQHRENPCAAERATCEPTYGYRHQLSLTDDIPAFTSAVANSKITGNLDNLEGGLDALMQVIV 251
              .|:...|||..:...|:|.:.:||.|.|||:...|.:.|....|:||||..||||||:|||..
Mouse   181 NTHPEKLRNPCPNKEKACQPPFAFRHVLKLTDNSNQFQTEVGKQLISGNLDAPEGGLDAIMQVAA 245

  Fly   252 CTKEIGWKEQARKVVILVTDGFMHLAGDGLLAGIIQRNDKQCHLNKAGEYTGSLNYDYPSLEEIY 316
            |.:||||:...|.:|....||| |.||||.|..|:..||.:||| :...|..|..:||||:.::.
Mouse   246 CPEEIGWRNVTRLLVFATDDGF-HFAGDGKLGAILTPNDGRCHL-EDNMYKRSNEFDYPSVGQLA 308

  Fly   317 RELLRRKINVIFAVTEEVVSSYWELSALMKEISYVDILSADSSNILELIKKSYESLIKRTQFADN 381
            .:|....|..|||||:::|.:|.:|:.::.: |.|..||.||||:::|||.:|..|..|. |.|:
Mouse   309 HKLSESNIQPIFAVTKKMVKTYEKLTEIIPK-SAVGELSDDSSNVVQLIKNAYYKLSSRV-FLDH 371

  Fly   382 S--PDFIDMAYYTDCGGQFPSLQK-RNYCNNVTLGKQIDFYVDVTLKKYPDNQVYTHKIRVEETS 443
            |  ||.:.:.|.:.|.....|:.| |..|:.|.:...:.|.|.|...:....|.:.    :....
Mouse   372 STLPDTLKVTYDSFCSNGASSIGKSRGDCDGVQINNPVTFQVKVMASECIQEQSFV----IRALG 432

  Fly   444 LSEFMDLDVELQRPCPCQETPDPENEEGRFLCDYKGYLYCGMCECDEGWTGTYCNCPTDATNVTS 508
            .::.:.:.|..|..|.|:   |...|:.  ||..||.:.||:|.|:.|:.|..|.|.|..   .|
Mouse   433 FTDTVTVQVRPQCECQCR---DQSREQS--LCGGKGVMECGICRCESGYIGKNCECQTQG---RS 489

  Fly   509 NEALLQKCRQPFSDKSTSELVCSNHGDCDCGTCLC------DPGYTGPFCECRECLDCD------ 561
            ::.|.:.||     |..|.:|||..|||.||.|:|      :....|.:||| :.::|:
Mouse   490 SQELERNCR-----KDNSSIVCSGLGDCICGQCVCHTSDVPNKEIFGQYCEC-DNVNCERYNSQV 548

  Fly   562 ---EKLADCFCGQCVCKYGWSGSKCNCDGDTDACVGPTGEICSERGTCQCEECQCEEPYLGKFCE 623
               .....|.||:|.||.|:.||.|.|...|..|:......||.||.|||..|.|:|.|....||
Mouse   549 CGGSDRGSCNCGKCSCKPGYEGSACQCQRSTTGCLNARLVECSGRGHCQCNRCICDEGYQPPMCE 613

  Fly   624 IDPE-----KDNKLCLFYEPCVTCLIEQKQGMGVCE-NLTEICSSLDRQETYPYNFVHELDPEQD 682
            ..|.     :||     :..|..||   |...|..| |.:..|:.:..| |.|.        ::.
Mouse   614 DCPSCGSHCRDN-----HTSCAECL---KFDKGPFEKNCSVQCAGMTLQ-TIPL--------KKK 661

  Fly   683 QCLVRLVNKHGIQCDSFFVYQVIDHSNFLTI---QAVDC-EPPDYVALVGYISAFTLLIGLLIIF 743
            .|..|  :..|  |...:..|..|..|...|   .:::| :.|:..|:||......:|||:|::.
Mouse   662 PCKER--DSEG--CWITYTLQQKDGRNIYNIHVEDSLECVKGPNVAAIVGGTVVGVVLIGVLLLV 722

  Fly   744 IILWYIRAKDAREYAKFEEDQ-KNSVRQENPIYRDPVGRYEVPK 786
            |........|.|||.:||::: |:....:||:::........||
Mouse   723 IWKALTHLTDLREYRRFEKEKLKSQWNNDNPLFKSATTTVMNPK 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Itgbn	NP_001303333.1	INB	38..460	CDD:197563	151/431 (35%)
		EGF_2	524..552	CDD:285248	12/33 (36%)
		Integrin_b_cyt	748..785	CDD:285884	9/37 (24%)
Itgb2	NP_032430.2	Integrin_beta	32..447	CDD:278776	150/429 (35%)
		Cysteine-rich tandem repeats	449..617		63/181 (35%)
		Integrin_B_tail	626..700	CDD:285239	20/89 (22%)
		Integrin_b_cyt	727..767	CDD:285884	11/40 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1226
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100678
Panther	1	1.100	-	-	O	PTHR10082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.780