DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Itgbn and itgb6

DIOPT Version :9

Sequence 1:	NP_001303333.1	Gene:	Itgbn / 35368	FlyBaseID:	FBgn0010395	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	XP_003199474.1	Gene:	itgb6 / 100499533	ZFINID:	ZDB-GENE-100812-2	Length:	782	Species:	Danio rerio

Alignment Length:	792	Identity:	247/792 - (31%)
Similarity:	390/792 - (49%)	Gaps:	77/792 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 DSIDDQCRH--ADSCERCLSAHLECAWCTDKE----YQVGYRCLSRRQLLNYNCSETDIYENQPV 85
            ||:...|..  |.||:.||....:|||||.:.    :.|..||.:...||...||..  :...||
Zfish    15 DSVGGTCSQISALSCDDCLQLGPQCAWCTLQNFTDFFPVDERCDTPEALLQKGCSGE--FVEFPV 77

  Fly    86 --LDVLQDKPLKDYETSDQAVQVTPQRAYLKLVKGNTQRMKLSYRTARNNPLDLYVLMDLTWTMR 148
              :.||:|:.|...........:.||:..|:|..|:....::..:..:::|:|:|.||||:.:|.
Zfish    78 TNVKVLKDQGLGKNSGHTNVSYIAPQKMRLQLRPGSQLTFQIQVQQPKDHPVDIYYLMDLSASMF 142

  Fly   149 DDKKTLEELGAQLSQTLKNLTGNYRLGFGSFADKPTLPMILPQHRE--NPCAAERATCEPTYGYR 211
            ||.|.:::||:.||:.:.|||..:|||||||.:||.||.|.....|  |||.:....|.||:|||
Zfish   143 DDLKKIKDLGSTLSKEMANLTSKFRLGFGSFVEKPVLPFIKITREELANPCRSFDLECLPTFGYR 207

  Fly   212 HQLSLTDDIPAFTSAVANSKITGNLDNLEGGLDALMQVIVCTKEIGWKEQARKVVILVTDGFMHL 276
            |.||||.....|...::..:|:.|:|..|||.||:||..||...|||:..:.|:::.|:|...|.
Zfish   208 HLLSLTSSTDRFNEIISKQQISANIDIPEGGFDAIMQAAVCGDRIGWRNDSMKLLVFVSDADSHF 272

  Fly   277 AGDGLLAGIIQRNDKQCHLNKAGEYTGSLNYDYPSLEEIYRELLRRKINVIFAVTEEVVSSYWEL 341
            ..|..::||:..||.:|||:...||:.:.:.:||:|.::..:|:...|.:|||||::...:|...
Zfish   273 GMDSKMSGIVVPNDGECHLDGNNEYSMTAHLEYPTLGQLVDKLVENNILLIFAVTKDQKENYENY 337

  Fly   342 SALMKEISYVDILSADSSNILELIKKSYESLIKRTQF---ADNSPDFIDMAYYTDCGGQFPSLQK 403
            ::|:...: |.:|::||.||||||..||:.|  |::.   ...:.:.:.|::...|.....:...
Zfish   338 ASLIPGAT-VGVLASDSRNILELIMTSYKEL--RSEIDLEVLGNTEGLQMSFTALCQDGTITPGH 399

  Fly   404 RNYCNNVTLGKQIDFYVDVTLKKYPDNQVYTHKIRVEETSLSEFMDLDVELQRPCPCQETPDPEN 468
            :| |.||..|..:.|.|.|.:|.....   ..:..:......:.:::::|.|..|.|.:||:..:
Zfish   400 KN-CTNVKAGDVVSFNVTVEIKGCLGG---PRRFSLRPVGFQDALEIELESQCVCSCHQTPETNS 460

  Fly   469 EEGRFLCDYKGYLYCGMCECDEGWTGTYCNCPTDATNVTSNEALLQKCRQPFSDKSTSELVCSNH 533
            .   |....:|.|.||.|.||.|:.|..|.|       |.::..:..||     .:....|||..
Zfish   461 S---FCSRGRGALECGECVCDPGFVGPKCEC-------TESQDQVSDCR-----ANEGAEVCSGQ 510

  Fly   534 GDCDCGTCLCDPG----YTGPFCECR--ECLDCDEKL----ADCFCGQCVCKYGWSGSKCNCDGD 588
            |:|.||.|:|.|.    ..||:|||.  .||....:|    .:|.||:|||..||.|..|||...
Zfish   511 GECFCGQCVCLPSSFGRVYGPYCECDNFSCLRFRGELCGGHGECDCGECVCDSGWMGEFCNCSTS 575

  Fly   589 TDACVGPTGEICSERGTCQCEECQCEEP-YLGKFCEIDPEKDNKLCLFYEPCVTCLIEQKQGMG- 651
            ..:||...|.:||.||.|.|.:|:|..| ..||.||..|...: :|..:..|..|.::.|:...
Zfish   576 NRSCVSSDGSVCSGRGRCVCGKCECSVPGASGKHCERCPTCGD-ICSIHRSCAECFLKAKEPSDE 639

  Fly   652 ---VCENL-TEICSSLDRQET--YPYNFVHELDPEQDQCLVRLVNKHGIQCDSFFVYQVIDHSNF 710
               .|.:| |.:.:|.|.:|:  .|.....|     :.||:.            |.....||.:.
Zfish   640 CAVKCSSLHTAVSNSTDFEESRAAPCTLQSE-----ESCLLS------------FSLVASDHGSI 687

  Fly   711 L-TIQAVDC-EPPDYVALVGYISAFTLLIGLLIIFIILWYIRAKDAREYAKFEEDQKNSVRQE-- 771
            : ..:..|| |||:...:...:....|:||:.::.|..:.:...|.:|.||||.::..:..|.
Zfish   688 IYNPKLYDCSEPPNAPLIALGVCMSVLIIGIALLVIWKFLVSVHDRKEVAKFEAEKAKAKWQSGT 752

  Fly   772 NPIYRDPVGRYE 783
            ||::|.....::
Zfish   753 NPLFRSSTSTFK 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Itgbn	NP_001303333.1	INB	38..460	CDD:197563	142/432 (33%)
		EGF_2	524..552	CDD:285248	12/31 (39%)
		Integrin_b_cyt	748..785	CDD:285884	10/38 (26%)
itgb6	XP_003199474.1	Integrin_beta	28..450	CDD:278776	141/430 (33%)
		EGF_2	542..570	CDD:285248	10/27 (37%)
		Integrin_B_tail	620..700	CDD:285239	20/96 (21%)
		Integrin_b_cyt	727..769	CDD:285884	10/38 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596174
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1226
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100678
Panther	1	1.100	-	-	O	PTHR10082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.750