Protein Alignment Itgbn and itgb8

DIOPT Version :10

• Sequence 1: NP_523608.2
• Gene: Itgbn / 35368
• FlyBaseID: FBgn0010395
• Length: 799
• Species: Drosophila melanogaster
• Sequence 2: XP_002933344.3
• Gene: itgb8 / 100494899
• XenbaseID: XB-GENE-950732
• Length: 808
• Species: Xenopus tropicalis
• Alignment Length: 819
• Identity: 223/819 - (27%)
• Similarity: 342/819 - (41%)
• Gaps: 164/819 - (20%)

  Fly     7 RAFLWIY----LVFLIAEISHSDADSIDDQC--RHADSCERCLSAHLECAWCTDKEYQV----GY 61
            |.|:.|.    |:||:..:    ..|::::|  ..|.:|.:||:...||.|||.:::.:    ..
 Frog    69 RCFMSILRAFGLLFLLLGL----CQSVENRCSSSSATTCAKCLALGPECGWCTQEDFMMDSTENE 129

  Fly    62 RCLSRRQLLNYNCSETDIYENQPVLDVLQDKPLKDYETSDQAVQVTPQRAYLKLVKGNTQRMKLS 126
            ||.:...|.:..|.:..|  ..|....   :||...:|:.   ||||....:.:..|......|.
 Frog   130 RCDTALNLKSKGCRQDSI--EYPTAHA---QPLSSRDTNS---QVTPAEVSVHIRPGAKVNFMLK 186

  Fly   127 YRTARNNPLDLYVLMDLTWTMRDDKKTLEELGAQLSQTLKNLTGNYRLGFGSFADKPTLPMIL-- 189
            ....|..|||:|.|:|::.:|......|..:|..|||.:.|.:.:.:.|||||.|||..|.|.
 Frog   187 VHHLRKYPLDIYYLVDISASMHKSIARLNSVGFDLSQKMANFSDDIKYGFGSFVDKPVSPYISVH 251

  Fly   190 PQHRENPCAAERATCEPTYGYRHQLSLTDDIPAFTSAVANSKITGNLDNLEGGLDALMQVIVCTK 254
            ||..:|.|:.....|.|.:||.:.|.||.:...|.:.|...:|.||:||.||..:|::|..||..
 Frog   252 PQKIKNQCSVVDLVCMPPHGYINVLPLTYNTTKFKNVVGKQRIAGNIDNPEGAFEAMLQAAVCNT 316

  Fly   255 EIGWKEQARKVVILVTDGFMHLAGDGLLAGIIQRNDKQCHLNKAGEYTGSLNYDYPSLEEIYREL 319
            :|||:::||.::||:||...|||.|..||||:..||..||| |...|..|.:.:||||..:..:|
 Frog   317 DIGWRKEARHLLILMTDQTSHLALDSKLAGIVTPNDGSCHL-KDNVYIRSSDMEYPSLGLLGEKL 380

  Fly   320 LRRKINVIFAVTEEVVSSYWELSALMKEISYVDILSADSSNILELIKKSYESLIKRTQF-ADNSP 383
            ....|:.:|||.....:.|.:|..|:...: ...|...:||:..|:..:|:.|:...:. .||..
 Frog   381 TENHISGVFAVQGPQFNWYKDLLPLIPGTT-ARQLDPFASNMKNLVFDAYKMLLSEVKIEVDNPI 444

  Fly   384 DFIDMAYYTDCGGQFPSLQKRN---YCNNVTLGKQIDFYVDVTL--------KKYPDNQVYTHKI 437
            ..|.:.....|    |...:|:   .|.||...:::.|.|.:|:        :.|    :....:
 Frog   445 KGIHVHVTAIC----PDGTRRSGKEGCQNVKANEKVFFNVTLTMDSCDVHNGRDY----IVLRPL 501

  Fly   438 RVEETSLSEFMDLDVELQRPCPCQETPDPENEEGRFLCDYKGYLYCGMCECDEGWTGTYCN---C 499
            ...||::       :::.|.|.||             |:...... |.|..|:   .|.|.   |
 Frog   502 GFNETAI-------IKVHRDCTCQ-------------CNSVSQAK-GKCVTDD---STDCQTTPC 542

  Fly   500 PTDATNVTSNEALLQKCRQPFSDKSTSELVCSNHGDCDCGTCLCDP----GYTGPFCECRECLDC 560
            ..:..:....::..:.||     .|.|:.|||..|.|.||.|.|..    ...|.:|| ::...|
 Frog   543 KEEICSSDELDSASESCR-----ASPSQPVCSGRGVCLCGKCFCQKTKLGAIYGKYCE-KDTFSC 601

  Fly   561 ---DEKL----ADCFCGQCVCKYGWSGSKCNCDGD-TDACVGPTGEICSERGTCQCEECQCEEPY 617
               ..||    .||..|:|.|..||...:|:|... ...|:...|.:||.||.|||.:|:|
 Frog   602 PYHHGKLCSGNGDCEDGKCRCFNGWESDRCHCASSLRKHCMNSKGLVCSGRGVCQCGKCEC---- 662

  Fly   618 LGKFCEIDPEKDNKLCLFYEPCVTCLIEQKQGMGVCENLTEICSSLDRQETYPYNFVHELDPEQD 682
                  .|.:....||.:......|  |..||..   |::|                    ||.
 Frog   663 ------TDAKSFGPLCQYCTDNWNC--EHFQGSA---NVSE--------------------PEG- 695

  Fly   683 QCLVRLVNKHGIQCDSFFVYQVIDHSNFLTIQAVDC-EPPDYVALVGYISAFTLLIGLLIIF--- 743
                   |.:...| :..|| .||       |..:| ..|..:.|...||..|.|:|:|.:.
 Frog   696 -------NLYETAC-ALLVY-YID-------QTSECFSDPRILTLFFIISIVTFLLGILTVLLTR 744

  Fly   744 -IILWYIRAKDAREYAKFEEDQKNSVRQENPIYRDPVGR 781
             |||.:.:.:|                :..|.||.|..:
 Frog   745 HIILHHHKTRD----------------RSTPSYRTPTNK 767

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Itgbn	NP_523608.2	INB	38..460	CDD:197563	131/439 (30%)
		EGF_2	529..552	CDD:400365	10/26 (38%)
		Integrin_b_cyt	752..785	CDD:462580	5/30 (17%)
itgb8	XP_002933344.3	vWFA	102..517	CDD:469594	131/439 (30%)