DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Itgbn and itgb8

DIOPT Version :9

Sequence 1:	NP_001303333.1	Gene:	Itgbn / 35368	FlyBaseID:	FBgn0010395	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	XP_002933344.3	Gene:	itgb8 / 100494899	XenbaseID:	XB-GENE-950732	Length:	808	Species:	Xenopus tropicalis

Alignment Length:	819	Identity:	223/819 - (27%)
Similarity:	342/819 - (41%)	Gaps:	164/819 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 RAFLWIY----LVFLIAEISHSDADSIDDQC--RHADSCERCLSAHLECAWCTDKEYQV----GY 61
            |.|:.|.    |:||:..:    ..|::::|  ..|.:|.:||:...||.|||.:::.:    ..
Frog    69 RCFMSILRAFGLLFLLLGL----CQSVENRCSSSSATTCAKCLALGPECGWCTQEDFMMDSTENE 129

  Fly    62 RCLSRRQLLNYNCSETDIYENQPVLDVLQDKPLKDYETSDQAVQVTPQRAYLKLVKGNTQRMKLS 126
            ||.:...|.:..|.:..|  ..|....   :||...:|:.   ||||....:.:..|......|.
Frog   130 RCDTALNLKSKGCRQDSI--EYPTAHA---QPLSSRDTNS---QVTPAEVSVHIRPGAKVNFMLK 186

  Fly   127 YRTARNNPLDLYVLMDLTWTMRDDKKTLEELGAQLSQTLKNLTGNYRLGFGSFADKPTLPMIL-- 189
            ....|..|||:|.|:|::.:|......|..:|..|||.:.|.:.:.:.|||||.|||..|.|.
Frog   187 VHHLRKYPLDIYYLVDISASMHKSIARLNSVGFDLSQKMANFSDDIKYGFGSFVDKPVSPYISVH 251

  Fly   190 PQHRENPCAAERATCEPTYGYRHQLSLTDDIPAFTSAVANSKITGNLDNLEGGLDALMQVIVCTK 254
            ||..:|.|:.....|.|.:||.:.|.||.:...|.:.|...:|.||:||.||..:|::|..||..
Frog   252 PQKIKNQCSVVDLVCMPPHGYINVLPLTYNTTKFKNVVGKQRIAGNIDNPEGAFEAMLQAAVCNT 316

  Fly   255 EIGWKEQARKVVILVTDGFMHLAGDGLLAGIIQRNDKQCHLNKAGEYTGSLNYDYPSLEEIYREL 319
            :|||:::||.::||:||...|||.|..||||:..||..||| |...|..|.:.:||||..:..:|
Frog   317 DIGWRKEARHLLILMTDQTSHLALDSKLAGIVTPNDGSCHL-KDNVYIRSSDMEYPSLGLLGEKL 380

  Fly   320 LRRKINVIFAVTEEVVSSYWELSALMKEISYVDILSADSSNILELIKKSYESLIKRTQF-ADNSP 383
            ....|:.:|||.....:.|.:|..|:...: ...|...:||:..|:..:|:.|:...:. .||..
Frog   381 TENHISGVFAVQGPQFNWYKDLLPLIPGTT-ARQLDPFASNMKNLVFDAYKMLLSEVKIEVDNPI 444

  Fly   384 DFIDMAYYTDCGGQFPSLQKRN---YCNNVTLGKQIDFYVDVTL--------KKYPDNQVYTHKI 437
            ..|.:.....|    |...:|:   .|.||...:::.|.|.:|:        :.|    :....:
Frog   445 KGIHVHVTAIC----PDGTRRSGKEGCQNVKANEKVFFNVTLTMDSCDVHNGRDY----IVLRPL 501

  Fly   438 RVEETSLSEFMDLDVELQRPCPCQETPDPENEEGRFLCDYKGYLYCGMCECDEGWTGTYCN---C 499
            ...||::       :::.|.|.||             |:...... |.|..|:   .|.|.   |
Frog   502 GFNETAI-------IKVHRDCTCQ-------------CNSVSQAK-GKCVTDD---STDCQTTPC 542

  Fly   500 PTDATNVTSNEALLQKCRQPFSDKSTSELVCSNHGDCDCGTCLCDP----GYTGPFCECRECLDC 560
            ..:..:....::..:.||     .|.|:.|||..|.|.||.|.|..    ...|.:|| ::...|
Frog   543 KEEICSSDELDSASESCR-----ASPSQPVCSGRGVCLCGKCFCQKTKLGAIYGKYCE-KDTFSC 601

  Fly   561 ---DEKL----ADCFCGQCVCKYGWSGSKCNCDGD-TDACVGPTGEICSERGTCQCEECQCEEPY 617
               ..||    .||..|:|.|..||...:|:|... ...|:...|.:||.||.|||.:|:|
Frog   602 PYHHGKLCSGNGDCEDGKCRCFNGWESDRCHCASSLRKHCMNSKGLVCSGRGVCQCGKCEC---- 662

  Fly   618 LGKFCEIDPEKDNKLCLFYEPCVTCLIEQKQGMGVCENLTEICSSLDRQETYPYNFVHELDPEQD 682
                  .|.:....||.:......|  |..||..   |::|                    ||.
Frog   663 ------TDAKSFGPLCQYCTDNWNC--EHFQGSA---NVSE--------------------PEG- 695

  Fly   683 QCLVRLVNKHGIQCDSFFVYQVIDHSNFLTIQAVDC-EPPDYVALVGYISAFTLLIGLLIIF--- 743
                   |.:...| :..|| .||       |..:| ..|..:.|...||..|.|:|:|.:.
Frog   696 -------NLYETAC-ALLVY-YID-------QTSECFSDPRILTLFFIISIVTFLLGILTVLLTR 744

  Fly   744 -IILWYIRAKDAREYAKFEEDQKNSVRQENPIYRDPVGR 781
             |||.:.:.:|                :..|.||.|..:
Frog   745 HIILHHHKTRD----------------RSTPSYRTPTNK 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Itgbn	NP_001303333.1	INB	38..460	CDD:197563	131/439 (30%)
		EGF_2	524..552	CDD:285248	12/31 (39%)
		Integrin_b_cyt	748..785	CDD:285884	5/34 (15%)
itgb8	XP_002933344.3	vWFA	102..517	CDD:412136	131/439 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010