DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Itgbn and itgb7

DIOPT Version :9

Sequence 1:	NP_001303333.1	Gene:	Itgbn / 35368	FlyBaseID:	FBgn0010395	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	XP_002936686.2	Gene:	itgb7 / 100486332	XenbaseID:	XB-GENE-1012435	Length:	766	Species:	Xenopus tropicalis

Alignment Length:	801	Identity:	254/801 - (31%)
Similarity:	388/801 - (48%)	Gaps:	84/801 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 AFLWIYLVFLIAEISHSDADSIDDQCRHADSCERCLSAHLECAWCTDKEY-----QVGYRCLSRR 67
            :|:|: |..|....|....    |.|:|..||..|:.:...|:||..|.:     ..|.||..|.
Frog     5 SFIWV-LGLLCTPQSWGST----DVCKHTGSCNECILSSASCSWCNAKNFTKSGESEGLRCAVRA 64

  Fly    68 QLLNYNCSETDIYENQPVLDVLQDKPLKDYETSDQAVQVTPQRAYLKLVKGNTQRMKLSYRTARN 132
            :||:..|.:..|.:....::|||.:||.:....:..:|:.||...:||..|..::.::.::.|..
Frog    65 ELLSRGCDKDHIIDPHGSVNVLQGQPLSESADQESVIQLHPQAINVKLRPGEQRKFRVEFKRAEG 129

  Fly   133 NPLDLYVLMDLTWTMRDDKKTLEELGAQLSQTLKNLTGNYRLGFGSFADKPTLPMI--LPQHREN 195
            .|:|||.||||:::|:||.:.:::||:.:.:.|..:|.:..:|||.|.||..||.:  :....||
Frog   130 YPIDLYYLMDLSYSMKDDLENMKKLGSDIKKALHKVTKSVHIGFGCFVDKTVLPFVSTVKSKLEN 194

  Fly   196 PCAAERATCEPTYGYRHQLSLTDDIPAFTSAVANSKITGNLDNLEGGLDALMQVIVCTKEIGWKE 260
            ||......|:|.:.|||.||||.::..|...|:...|:||||..||||||::|..|||..|||:.
Frog   195 PCPLRGEKCQPPFSYRHVLSLTSNLTLFQMRVSAENISGNLDMPEGGLDAMLQAAVCTDVIGWRN 259

  Fly   261 QARKVVILVTDGFMHLAGDGLLAGIIQRNDKQCHLNKAGEYTGSLNYDYPSLEEIYRELLRRKIN 325
            ..| :::..:|...|.||||.||||....|..||||:..||:.|..|||||:..:.:.|....|.
Frog   260 VTR-LLVFASDDVFHSAGDGKLAGIYLPADGHCHLNRNAEYSQSYLYDYPSVGHLVQVLTAANIQ 323

  Fly   326 VIFAVTEEVVSSYWELSALMKEISYVDILSADSSNILELIKKSYESLIKRTQFAD-NSPDFIDMA 389
            .|||||..|||:|..||.|:.: |.|..|..||||::.||.::|.:|........ |.|..|.::
Frog   324 PIFAVTSSVVSTYKALSNLIPK-SAVGELKEDSSNVVNLISEAYNNLSSTINLEHVNLPKGIHIS 387

  Fly   390 YYTDCGGQFPSLQKRNYCNNVTLGKQIDFYVDVTL---KKYPDNQVYTHKIRVEETSLSEFMDLD 451
            |.:.|.......:.:..|:.|.:.:.:.|  ||||   |........:.::||  ...:|.:.:|
Frog   388 YDSHCSNSSTLGKAQGQCSGVRINQTVSF--DVTLWMDKTLCQQGKQSFQLRV--LGFTEELKVD 448

  Fly   452 VELQRPCPCQETPDPENEEGRFLCDY----KGYLYCGMCECDEGWTGTYCNCPTDATNVTSNEAL 512
            ||....|.|::.        ....||    .|...||:|.|.||.:|.:|.||.:..|
Frog   449 VEPLCACDCKDK--------ELFSDYCSRGLGNYSCGICSCLEGHSGKHCECPLEKHN------- 498

  Fly   513 LQKCRQPFSDK---STSELVCSNHGDCDCGTCLCDPGYTGPFCECRE--CLDCDEKLAD------ 566
                    :||   |.|.|:||.||.|.||.|.||..:.|..|:|.:  |...:.||..
Frog   499 --------NDKACWSNSHLLCSGHGRCQCGRCACDVSFRGDLCQCDDTSCERFEGKLCGGITRGV 555

  Fly   567 CFCGQCVCKYGWSGSKCNCDGDTDACVGPTGEICSERGTCQCEECQCEEPYLGKFCEIDPEKDNK 631
            |.||.|.|..|::||.|.|..||..| .....:||..|:|:|.:|:|...|..|:|...||...
Frog   556 CECGTCKCSDGYTGSACGCSTDTSGC-RTNDTLCSGHGSCECNKCKCHPGYYNKWCSECPECQT- 618

  Fly   632 LCLFYEPCVTCLIEQKQGMGVCE-NLTEICSSLD-RQETYPYNFVHELDPEQDQCLVRLVNKHGI 694
            :|.....|..|   :..|.|..: |.:..|.::: .....|...|.|          :|..:.|
Frog   619 ICKKLTNCAEC---KAFGKGFLKHNCSSSCQNINVTLAKAPLTGVRE----------KLCKEKG- 669

  Fly   695 QCDSFFVYQVIDHSNF--LTIQAVDCEPPDYVALVGYISAFTLLIGLLIIFIILWYIRAKDAREY 757
              :.|..:.|.:..:|  :|::......|....|:..::...:.||||||......:...|.:||
Frog   670 --EDFITFLVREEGDFFHVTVEEKQETAPVTKHLILGLTLGIVFIGLLIILAFRITVEIYDRQEY 732

  Fly   758 AKFEEDQKNSVRQE--NPIYR 776
            .:|::::.|:...|  ||:|:
Frog   733 NRFQKERSNAQWNELNNPLYK 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Itgbn	NP_001303333.1	INB	38..460	CDD:197563	152/432 (35%)
		EGF_2	524..552	CDD:285248	14/27 (52%)
		Integrin_b_cyt	748..785	CDD:285884	9/31 (29%)
itgb7	XP_002936686.2	vWFA	30..455	CDD:381780	151/430 (35%)
		EGF_2	581..610	CDD:285248	10/29 (34%)
		Integrin_B_tail	620..693	CDD:369622	16/88 (18%)
		Integrin_b_cyt	724..764	CDD:370082	9/30 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10082
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.110