DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Itgbn and itgb5

DIOPT Version :9

Sequence 1:	NP_001303333.1	Gene:	Itgbn / 35368	FlyBaseID:	FBgn0010395	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	NP_001135704.1	Gene:	itgb5 / 100216279	XenbaseID:	XB-GENE-6455199	Length:	807	Species:	Xenopus tropicalis

Alignment Length:	795	Identity:	251/795 - (31%)
Similarity:	397/795 - (49%)	Gaps:	81/795 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SCERCLSAHLECAWCTDKEY----QVGYRCLSRRQLLNYNCSETDIYENQPVLDVLQDKPLKDYE 98
            ||::||..|.:||||:.:|:    .|..||.....|::..|.:..|......:.|:::.||...|
Frog    43 SCQQCLVTHPQCAWCSQEEFGGSSTVTSRCDFAHNLISRGCKKEFIEGPGSTVTVIKNLPLSTKE 107

  Fly    99 TSDQA---VQVTPQRAYLKLVKGNTQRMKLSYRTARNNPLDLYVLMDLTWTMRDDKKTLEELGAQ 160
            :|...   :||.||:..|.|..|.....|:..|...:.|:|||.||||:.:|:||..|:..||..
Frog   108 SSSSQTNFIQVAPQKISLSLRPGAAASFKVQVRQVEDYPVDLYYLMDLSLSMKDDLNTIRNLGTI 172

  Fly   161 LSQTLKNLTGNYRLGFGSFADKPTLPM--ILPQHRENPCAAER--ATCEPTYGYRHQLSLTDDIP 221
            |:..:|.||.|:|||||||.||...|.  ..|:::.|||...:  ..|.|::|:||.|||||...
Frog   173 LAAEMKKLTSNFRLGFGSFVDKNISPFSYTAPKYQNNPCTGYKYSPVCVPSFGFRHLLSLTDKTN 237

  Fly   222 AFTSAVANSKITGNLDNLEGGLDALMQVIVCTKEIGWKEQARKVVILVTDGFMHLAGDGLLAGII 286
            :|.:.|...:::.|.|..||..||::|..||...|||:::|..::::.|||..|:|.||.|||::
Frog   238 SFNAEVQKQRVSRNRDAPEGAFDAILQAAVCGDRIGWRKEASHLLVITTDGVPHIALDGKLAGLV 302

  Fly   287 QRNDKQCHLNKAGEYTGSLNYDYPSLEEIYRELLRRKINVIFAVTEEVVSSYWELSALMKEISYV 351
            |.:|.:||||:..||:.|...|||||..:..:|....||:|||||......|...:||:...: .
Frog   303 QPHDGRCHLNEDNEYSASDQLDYPSLALLGEKLSENNINLIFAVTNSHYVLYKNFTALIPGTT-A 366

  Fly   352 DILSADSSNILELIKKSYESLIKRTQF-ADNSPDFIDMAYYTDC--GGQFPSLQKRNYCNNVTLG 413
            :||..||.||:::|..:|.::..:.:. ...||:.:.:::...|  |...|.::|   |.::.:|
Frog   367 EILDQDSQNIIQVIVSAYNNIRSKVELTVSESPEDLSLSFTATCQDGSSHPGVKK---CGDLKIG 428

  Fly   414 KQIDFYVDVTLKKYP---DNQVYTHKIRVEETSLSEFMDLDVELQRPCPCQETPDPENEEGRFLC 475
            ..:.|.|.|..:..|   ..|.:|    ::.....:.:::.|.....|.|.:..:|.:.:    |
Frog   429 DTVSFEVSVEARSCPPPGTEQTFT----IKPVGFRDSLEVTVTYNCSCSCAQQGEPASSK----C 485

  Fly   476 DYKGYLYCGMCECDEGWTGTYCNCPTD--ATNVTSNEALLQKCRQPFSDKSTSELVCSNHGDCDC 538
            ...|...||:|||:.|:.|..|.|..:  :::||.|     .||:     :..:.||:..|.|.|
Frog   486 SGNGTYTCGVCECEAGFLGGRCQCGEEELSSDVTQN-----TCRE-----AEGKTVCNGRGRCLC 540

  Fly   539 GTCLCDPG----YTGPFCECRE--CLDCDEKL----ADCFCGQCVCKYGWSGSKCNCDGDTDACV 593
            |.|:|...    .:|.||:|.:  |......|    .:|.||:|.|..|:.|..|||..:|..|:
Frog   541 GLCVCYQSEFGLISGSFCQCDDFSCARYKGALCSGHGECDCGECKCHAGYIGDNCNCTIETATCL 605

  Fly   594 GPTGEICSERGTCQCEECQCEEP-YLGKFCEIDPEKDNKLCLFYEPCVTCLIEQKQGMGVCENLT 657
            ...|::||.:|.|.|..|||.|| ..|:.||..|...: .|.....|:.|.:.|...:  .:|.|
Frog   606 SDDGQMCSGKGNCVCGRCQCIEPGAFGETCEKCPTCPD-ACGTKRDCIECRLYQTGQL--ADNQT 667

  Fly   658 EICSSLDRQETYPYNFVHELD---PEQDQCLVRLVNKHGIQCDSFFVY-QVIDHSNFLTIQAVDC 718
              |..|.:.|...   |.|||   ||...|:.:..:    .|...|.| :....|....::..:|
Frog   668 --CQKLCKDEIVT---VEELDTDNPEAAVCIYKTES----DCVMRFTYSEESGRSVLRVLKEPEC 723

  Fly   719 -EPPD----YVALVGYISAFTLLIGLLIIFIILWYIRAKDAREYAKFEEDQKNSVRQE---NPIY 775
             ..||    .:|:||.|    |||||:::.:....:...|.||:::| :.::...|.|   ||:|
Frog   724 ASAPDTLTVLLAVVGSI----LLIGLVLLAVWKLLVTIHDRREFSRF-QSERTRARYEMASNPLY 783

  Fly   776 RDPVGRYEVPKALSV 790
            |..|..:.|.:..|:
Frog   784 RPAVSTHNVDEMYSM 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Itgbn	NP_001303333.1	INB	38..460	CDD:197563	147/438 (34%)
		EGF_2	524..552	CDD:285248	9/31 (29%)
		Integrin_b_cyt	748..785	CDD:285884	11/39 (28%)
itgb5	NP_001135704.1	Integrin_beta	43..472	CDD:278776	146/436 (33%)
		Integrin_B_tail	645..727	CDD:285239	21/92 (23%)
		Integrin_b_cyt	754..791	CDD:285884	11/37 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010