DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Itgbn and itgb3b

DIOPT Version :9

Sequence 1:	NP_001303333.1	Gene:	Itgbn / 35368	FlyBaseID:	FBgn0010395	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	NP_001076417.1	Gene:	itgb3b / 100001836	ZFINID:	ZDB-GENE-071207-2	Length:	790	Species:	Danio rerio

Alignment Length:	802	Identity:	250/802 - (31%)
Similarity:	388/802 - (48%)	Gaps:	72/802 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LWIYLVFLIAEISHSDADSIDDQC--RHADSCERCLSAHLECAWCTDKEY----QVGYRCLSRRQ 68
            ||:|.|.:..    :|.....:.|  |.|.:|::||:.|..||||..:::    ....||..:|.
Zfish    11 LWVYCVIIFL----ADVGLGSNVCTSRGASTCQQCLAVHPTCAWCFQEDFGQDVPGSSRCDLKRN 71

  Fly    69 LLNYNCSETDIYENQPVLDVLQDKPLKDY---ETSDQAVQVTPQRAYLKLVKGNTQRMKLSYRTA 130
            |:...|::..:......:.|.:::.|.|.   .|:| ..|:.||..::.|...::|..||..|..
Zfish    72 LVEAGCNKGALEYPTSKMHVKENEDLSDKASGSTTD-VTQIQPQSIHISLRPDDSQVFKLKVRQV 135

  Fly   131 RNNPLDLYVLMDLTWTMRDDKKTLEELGAQLSQTLKNLTGNYRLGFGSFADKPTLPMILPQHRE- 194
            .:.|:|||.||||:::|.||...|..||..|::.:...|.|.|:|||:|.|||..|.:.....|
Zfish   136 EDYPVDLYYLMDLSYSMNDDLSQLRRLGRGLAEEMSKTTSNLRMGFGAFVDKPVSPYMYISPEEA 200

  Fly   195 --NPCAAERATCEPTYGYRHQLSLTDDIPAFTSAVANSKITGNLDNLEGGLDALMQVIVCTKEIG 257
              |||.:....|:|.:||||.||||:::..||..|...|::.|.|..|||.||::|..||..:||
Zfish   201 VLNPCYSIPYKCQPQFGYRHVLSLTEEVNRFTEEVKKQKVSRNRDAPEGGFDAIIQAAVCKDKIG 265

  Fly   258 WKEQARKVVILVTDGFMHLAGDGLLAGIIQRNDKQCHLNKAGEYTGSLNYDYPSLEEIYRELLRR 322
            |:..|..:::..||...|:|.||.:|||::.||.||::.:...|..|...|||||..|..::...
Zfish   266 WRPGASHLLVFTTDAKTHVALDGRMAGIVRPNDGQCYVGRDNIYNMSTTMDYPSLALITEKMSEN 330

  Fly   323 KINVIFAVTEEVVSSYWELSALMKEISYVDILSADSSNILELIKKSYESLIKRTQF-ADNSPDFI 386
            .||:|||||..|.|.|...|.|:...: |..||.||.|:::||:.:|..|..:.:. ..|.|:.:
Zfish   331 NINLIFAVTSHVESLYKNYSELIPGTA-VGTLSEDSHNVIQLIQDAYAKLRSKVELELLNVPEEL 394

  Fly   387 DMAYYTDC--GGQFPSLQKRNYCNNVTLGKQIDFYVDVTLKKYPDNQVYTHKIRVEETSLSEFMD 449
            .:.:...|  |...|.|:.   |:.:..|..:.|.|:...:..|..:..|..|:  .....:.:.
Zfish   395 SLTFNATCLNGEVIPGLRS---CSGLKRGDTVSFSVEARARGCPKEKRKTFTIK--PVGFKDTLQ 454

  Fly   450 LDVELQRPCPCQETPDPENEEGRFLCDY-KGYLYCGMCECDEGWTGTYCNCPTDATNVTSNEALL 513
            :.|..:..|.||...:||:.    :|.: .|...||:|.|..|..|..|.|.....:.|..:|
Zfish   455 ITVNFECECKCQAKAEPESP----VCHHGNGTYECGICLCHPGRLGPRCECAEGDYSPTEQDA-- 513

  Fly   514 QKCRQPFSDKSTSELVCSNHGDCDCGTCLC---DPGYT-GPFCECRE--CLDCDEKLAD----CF 568
              |..|  ||    ::||..|||.||.|:|   |.|.. |..|||.:  ||....:|..    |:
Zfish   514 --CSGP--DK----VICSGRGDCVCGQCVCHNNDFGKVWGKRCECDDFSCLRYKGELCSGHGTCY 570

  Fly   569 CGQCVCKYGWSGSKCNCDGDTDACVGPTGEICSERGTCQCEECQCEEP-YLGKFCEIDPEKDNKL 632
            ||.|.|...|.|..|||...||.|:...|.:||.||.|.|..|:|.:| ..|..|:..|...: .
Zfish   571 CGFCQCDPDWKGENCNCSTRTDTCMSSLGLLCSGRGQCVCGSCECTQPGAYGSTCDKCPTCPD-A 634

  Fly   633 CLFYEPCVTCLIEQKQGMGVCENLTEICSS----LDRQETYPYNFVHELDPEQDQCLVRLVNKHG 693
            |...:.||.|...::..:...::.|.||..    :|....:..|.|:....::|.|:.|
Zfish   635 CTLKKECVECKHFKRGKLFDDDSCTRICRDEIRLVDDLVFHDKNAVNCTYKDEDDCVQR------ 693

  Fly   694 IQCDSFFVYQVIDHSNFLT-IQAVDC-EPPDYVALVGYISAFTLLIGLLIIFIILWYIRAKDARE 756
                 |..|:.....:.|: ::..|| :.||.:.::..::...|.:||..:.|....|...|.||
Zfish   694 -----FQYYEDNSGKSILSLVKEPDCPKGPDILVVLLSVAGAILFLGLAALLIWKLLITIHDRRE 753

  Fly   757 YAKFEEDQKNSVRQ--ENPIYR 776
            :|||||::..:..:  .||:|:
Zfish   754 FAKFEEERARAKWETGHNPLYK 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Itgbn	NP_001303333.1	INB	38..460	CDD:197563	142/434 (33%)
		EGF_2	524..552	CDD:285248	12/31 (39%)
		Integrin_b_cyt	748..785	CDD:285884	12/31 (39%)
itgb3b	NP_001076417.1	Integrin_beta	37..463	CDD:278776	141/432 (33%)
		Integrin_B_tail	635..718	CDD:285239	18/93 (19%)
		Integrin_b_cyt	745..787	CDD:285884	12/31 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596171
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1226
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100678
Panther	1	1.100	-	-	O	PTHR10082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.750