DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and ABCC12

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_001380726.1	Gene:	ABCC12 / 94160	HGNCID:	14640	Length:	1359	Species:	Homo sapiens

Alignment Length:	1375	Identity:	434/1375 - (31%)
Similarity:	718/1375 - (52%)	Gaps:	182/1375 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KLQTNPRESAGIFSTLMFCFALPILFKGRKK-----TLEPTDLYNALKEHKAETLGDKFFATWQS 64
            :|..||.:.||:.|...|.:..|::.||.::     ||.|...|::     ::|...:|...|..
Human    40 RLAPNPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDS-----SDTNAKRFRVLWDE 99

  Fly    65 EVRSCGDSPKKEPSIIRVILKVFGWQLFLSGIVVGVLELGTRATLPLILGALIAEFTRNGNGDGL 129
            ||...|  |:| .|:..|:.| |.....|..||..:|.:...|..|.:|...|.:.|...:|. :
Human   100 EVARVG--PEK-ASLSHVVWK-FQRTRVLMDIVANILCIIMAAIGPTVLIHQILQQTERTSGK-V 159

  Fly   130 WAQIYGLTLIL-SILFSVLMFHPLMMGLMH-LAMKMRVAVSTAIYRKALRLSRTALGDTTTGQVV 192
            |..| ||.:.| :..|:.:.|..|...:.: .|::::||:||.::...  :|...|...:.|:|:
Human   160 WVGI-GLCIALFATEFTKVFFWALAWAINYRTAIRLKVALSTLVFENL--VSFKTLTHISVGEVL 221

  Fly   193 NLISND-LGRFDRALIHFHFLWLG---PLELLISSYFLYQQIGVASLYGIVILLLFLPIQTFLSR 253
            |::|:| ...|:.||    |..|.   |:.::..:.:.:..:|..:|.||.:.::|:|:|.|:::
Human   222 NILSSDSYSLFEAAL----FCPLPATIPILMVFCAAYAFFILGPTALIGISVYVIFIPVQMFMAK 282

  Fly   254 LTSRLRHQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRKVNYIRGTLL 318
            |.|..|....|.||:||:.|||.::.|::||||.|||.|...|:.:||.|...:.|..:::....
Human   283 LNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAWEKSFTNTIQDIRRRERKLLEKAGFVQSGNS 347

  Fly   319 SFEITLSRIAIFVSLLGFVLMGGELTAERAFSVTAFYNILRRTVCKFFPSGMSQFAEMMVTLRRI 383
            :....:|.|||.::|...:|:..:|||..||||.|.:|:::.::. ..|..:...||..|:|||:
Human   348 ALAPIVSTIAIVLTLSCHILLRRKLTAPVAFSVIAMFNVMKFSIA-ILPFSIKAMAEANVSLRRM 411

  Fly   384 KGFMMRSETEALYLKGGQTNKLFEGEPLVKLQSFQARWNH------------------------- 423
            |..:: .::...|:...:     :.:.::.|.:....|.|
Human   412 KKILI-DKSPPSYITQPE-----DPDTVLLLANATLTWEHEASRKSTPKKLQNQKRHLCKKQRSE 470

  Fly   424 -------------------DHVEPVLENINISLSPPQLVAVIGPVGSGKSSLIQAILGELPGESG 469
                               |.::.||.:|:..:...:::.:.|.||||||||:.|:||::..:.|
Human   471 AYSERSPPAKGATGPEEQSDSLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKG 535

  Fly   470 KLKVQGDISYASQEPWLFNASVRDNILFGLPMDKHRYRNVIRNCALERDF-ELLHGDRTFVGERG 533
            .:.|.|.::|.||:.|:|:.:||:|||||...|..||::.:|.|.|::|. .|.:||.|.:||||
Human   536 VVAVNGTLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERG 600

  Fly   534 ASLSGGQRARISLARAVYRQADTYLLDDPLSAVDTHVGRHLFEECMRGFLRDKLVILVTHQLQFL 598
            .:||||||.|||||||||.....|||||||||||.|||:|:||||::..||.|.|:|||||||||
Human   601 LNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTHQLQFL 665

  Fly   599 EHADLIVIMDKGKISAVGTYEEMLKSGQDFGKLL------------------ATEAQEMGDSNQE 645
            |..|.:::::.|:|...||::|:::....:.||:                  ..||.:...:.:|
Human   666 ESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHLYNAAMVEAFKESPAERE 730

  Fly   646 Q-----VNAEGDSRNDKSTYSRQSSRVSRVSVTSVDSSTESILDNERQPAQ-ESRSQGKIGLGIY 704
            :     |.|.|:.:::    .::|...|....|.|.         |.|..| ||..:|.:....|
Human   731 EDAGIIVLAPGNEKDE----GKESETGSEFVDTKVP---------EHQLIQTESPQEGTVTWKTY 782

  Fly   705 GKYFSAGSGWLMVILVAFFCLGTQILASGGDYFLSYWVKNNDSSSS---------------TDI- 753
            ..|..|..|:|:.:...|..|.....|:..:::|..|:......:.               .||
Human   783 HTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGLWLDKGSRMTCGPQGNRTMCEVGAVLADIG 847

  Fly   754 -----YIFSGINAALVIFALLRTLLFFSMAMHSSTQLHNTMFQGVSRTALYFFHANPSGRILNRF 813
                 ::::.....:::|.:.:..:|....:.:|:.||:|:|..:.::.:.||...|:||::|||
Human   848 QHVYQWVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVFDKILKSPMSFFDTTPTGRLMNRF 912

  Fly   814 AMDLGQVDEILPAVMLDCIQIFLTISGIIGVLCITNPWYLINTITMFLAFHFLRTFYLSTSRDLK 878
            :.|:.::|..||....:.:|.|..:..|:.:|....|..|:...::.:.|..|...:....::||
Human   913 SKDMDELDVRLPFHAENFLQQFFMVVFILVILAAVFPAVLLVVASLAVGFFILLRIFHRGVQELK 977

  Fly   879 RLEAIARSPMYSHFSATLNGLSTIRAMEAQDLLTKEYDNYQDIHSSGYYTFLSTN---RAFGYYL 940
            ::|.::|||.::|.::::.||..|.|             |....|...|..|..|   |.|...:
Human   978 KVENVSRSPWFTHITSSMQGLGIIHA-------------YGKKESCITYHLLYFNCALRWFALRM 1029

  Fly   941 DL------FCVAYVISVTLMSYFNPPVDNPGQIGLVITQAMSMTGTVQWGMRQSAELENSMTSVE 999
            |:      |.||.:::::..|.      :....||.::..:.::|.:|..:|...|.:...||||
Human  1030 DVLMNILTFTVALLVTLSFSSI------STSSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSVE 1088

  Fly  1000 RVLEYRHLEAEGEFESPDDKKP------PMNWPQEGLISAEQLSLRYNPDPKADRVLKSLNFIIM 1058
            .:.||.....      |:...|      |.:||..|.|:.....:||..:  ...||.|||..|.
Human  1089 LLREYISTCV------PECTHPLKVGTCPKDWPSRGEITFRDYQMRYRDN--TPLVLDSLNLNIQ 1145

  Fly  1059 PREKIGIVGRTGAGKSSLINALFRL-SYNEGSLVIDNTDILGIGLHDLRSKISIIPQEPVLFSGT 1122
            ..:.:|||||||:|||||..||||| ....|::.||..||..:.|.|||:|:::|||:||||.||
Human  1146 SGQTVGIVGRTGSGKSSLGMALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGT 1210

  Fly  1123 LRCNLDPFEQYADEKLWEALEEVHLKDEVSELPNGLESVVAEGGSNYSVGQRQLVCLARAILREN 1187
            :|.||||||.:.||.||:.||...::|.:.:||..|::.|.|.|.|:|||:|||:|:|||:||.:
Human  1211 VRYNLDPFESHTDEMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNS 1275

  Fly  1188 RILVMDEATANVDPQTDALIQSTIRRKFRDCTVLTIAHRLNTIIDSDRVMVLDAGTLVEFGSPFE 1252
            :|:::|||||::|.:||.|:|:||:..|:.||||||||||||:::.|.|:|::.|.::||..| |
Human  1276 KIILLDEATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKP-E 1339

  Fly  1253 LLTQSWSKVF 1262
            :|.:.....|
Human  1340 VLAEKPDSAF 1349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	433/1367 (32%)
		ABC_membrane	92..362	CDD:294371	84/275 (31%)
		ABCC_MRP_domain1	412..611	CDD:213217	98/243 (40%)
		ABC_membrane	718..981	CDD:294371	60/292 (21%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	111/221 (50%)
ABCC12	NP_001380726.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	446..491		0/44 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151584
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.660