DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and ABCC3

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_003777.2	Gene:	ABCC3 / 8714	HGNCID:	54	Length:	1527	Species:	Homo sapiens

Alignment Length:	1359	Identity:	455/1359 - (33%)
Similarity:	716/1359 - (52%)	Gaps:	123/1359 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AKKLQTN--PRESAGIFSTLMFCFALPILFKGRKKTLEPTDLYNALKEHKAETLGDKFFATWQSE 65
            ||.:..|  |..|||..|.|.|.:...:...|.:..||..||::..:|.:::.:..:....|:.:
Human   199 AKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEAWRKQ 263

  Fly    66 VRS---------------------CGDSPK-KEPSIIRVILKVFGWQLFLSGIVVGVLELGTRAT 108
            .:.                     .|..|: ::||.::.:|..||....:|.....:.:|.:...
Human   264 EKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKLIQDLLSFIN 328

  Fly   109 LPLILGALIAEFTRNGNGDGLWA-QIYGLTLILSILFSVLM---FHPLMMGLMHLAMKMRVAVST 169
             |.:|..|| .|..|......|. .:.||..:.|::.|:::   :|.:.:    ..:|.|..:..
Human   329 -PQLLSILI-RFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIFV----TGVKFRTGIMG 387

  Fly   170 AIYRKALRLSRTALGDTTTGQVVNLISNDLGRFDRALIHFHFLWLGPLELLISSYFLYQQIGVAS 234
            .||||||.::.:....:|.|::|||:|.|..||.......:.||..||:::::.|||:|.:|.:.
Human   388 VIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSV 452

  Fly   235 LYGIVILLLFLPIQTFLSRLTSRLR----HQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRL 295
            |.|:..::|.:|:.   ..:..::|    .|..|: |.|:::|:||::||:|:|:|.||..|.:.
Human   453 LAGVAFMVLLIPLN---GAVAVKMRAFQVKQMKLK-DSRIKLMSEILNGIKVLKLYAWEPSFLKQ 513

  Fly   296 IERLRRSEMSSIRKVNYIRGTLL------SFEITLSRIAIFVSLLGFVLMGGELTAERAFSVTAF 354
            :|.:|:.|:..:|...|:..|..      .|.:||..:.::|    :|.....|.||:||...:.
Human   514 VEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYV----YVDPNNVLDAEKAFVSVSL 574

  Fly   355 YNILRRTVCKFFPSGMSQFAEMMVTLRRIKGFMMRSETEALYLKGGQTNKLFEGEPLVKLQSFQA 419
            :||||..: ...|..:|...:..|:|:||:.|:.:.|.:...::    .|.......:.:.|...
Human   575 FNILRLPL-NMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVE----RKTISPGYAITIHSGTF 634

  Fly   420 RWNHDHVEPVLENINISLSPPQLVAVIGPVGSGKSSLIQAILGELPGESGKLKVQGDISYASQEP 484
            .|..| :.|.|.:::|.:....||||:||||.|||||:.|:|||:....||:.::|.::|..|:.
Human   635 TWAQD-LPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQA 698

  Fly   485 WLFNASVRDNILFGLPMDKHRYRNVIRNCALERDFELL-HGDRTFVGERGASLSGGQRARISLAR 548
            |:.|.::::|:|||..::..||:..:..|||..|.|:| .||:|.:||:|.:||||||.|:||||
Human   699 WIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLAR 763

  Fly   549 AVYRQADTYLLDDPLSAVDTHVGRHLFEECM--RGFLRDKLVILVTHQLQFLEHADLIVIMDKGK 611
            |||..||.:||||||||||:||.:|:|:..:  .|.|..|..:||||.:.||...|.|:::..|:
Human   764 AVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQ 828

  Fly   612 ISAVGTYEEMLKSGQDFGKLLATEA--QEMGDSNQEQVNAEGD------------------SRND 656
            :|.:|.|..:|:....|...|...|  ::.|.........||.                  :.||
Human   829 VSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDND 893

  Fly   657 KSTYSRQSSRVSRVSVTSVDSS-------------------TESILDNERQPAQESRSQGKIGLG 702
            ..||..|...:.::|..|.|..                   ||:..|. ....:|..:.|.:.|.
Human   894 PVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADG-ALTQEEKAAIGTVELS 957

  Fly   703 IYGKYFSAGSGWLMVILVAFFCLGTQILASGGDYFLSYWV-------KNNDSSSSTDIYIFSGIN 760
            ::..|..| .|....:.:....:|....|.|.:.:||.|.       :.|::|....:|...||.
Human   958 VFWDYAKA-VGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGIL 1021

  Fly   761 AALVIFALLRTLLFFSMAMHSSTQLHNTMFQGVSRTALYFFHANPSGRILNRFAMDLGQVDEILP 825
            ...::  :|..:...:..:.::..||..:.....|:...||...|||||||.|:.|:..|||:|.
Human  1022 QGFLV--MLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLA 1084

  Fly   826 AVMLDCIQIFLTISGIIGVLCITNPWYLINTITMFLAFHFLRTFYLSTSRDLKRLEAIARSPMYS 890
            .|:|..:..|......:.|:..:.|.:.:..:.:.:.:..::.||.:|||.|||||:::|||:||
Human  1085 PVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYS 1149

  Fly   891 HFSATLNGLSTIRAMEAQDLLTKEYDNYQDIHSSGYYTFLSTNRAFGYYLDLFCVAYVISVTLMS 955
            |||.|:.|.|.|||...........|...|.:....|.::.:||.....::......|:...|.:
Human  1150 HFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFA 1214

  Fly   956 YFNPPVDNPGQIGLVITQAMSMTGTVQWGMRQSAELENSMTSVERVLEYRHLEAEGEFESP---D 1017
            .......|||.:||.::.::.:|..:.|.:|..::||:::.:||||.||    ::.|.|:|   :
Human  1215 VIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEY----SKTETEAPWVVE 1275

  Fly  1018 DKKPPMNWPQEGLISAEQLSLRYNPDPKADRVLKSLNFIIMPREKIGIVGRTGAGKSSLINALFR 1082
            ..:||..||..|.:.....|:||.|.  .|.||:.|:..:...||:||||||||||||:...|||
Human  1276 GSRPPEGWPPRGEVEFRNYSVRYRPG--LDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFR 1338

  Fly  1083 -LSYNEGSLVIDNTDILGIGLHDLRSKISIIPQEPVLFSGTLRCNLDPFEQYADEKLWEALEEVH 1146
             |...:|.:.||..::..||||||||:::||||:|:|||||||.|||||..|::|.:|.|||..|
Human  1339 ILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSH 1403

  Fly  1147 LKDEVSELPNGLESVVAEGGSNYSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQSTI 1211
            |...||..|.||:...:|||.|.|||||||||||||:||::||||:|||||.:|.:||.|||:||
Human  1404 LHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATI 1468

  Fly  1212 RRKFRDCTVLTIAHRLNTIIDSDRVMVLDAGTLVEFGSPFELLTQSWSKVFYGMVLQTG 1270
            |.:|..|||||||||||||:|..||:|||.|.:.||.||..|:..  ..:||||....|
Human  1469 RTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAA--RGIFYGMARDAG 1525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	448/1341 (33%)
		ABC_membrane	92..362	CDD:294371	80/283 (28%)
		ABCC_MRP_domain1	412..611	CDD:213217	89/201 (44%)
		ABC_membrane	718..981	CDD:294371	72/269 (27%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	128/221 (58%)
ABCC3	NP_003777.2	SunT	7..1526	CDD:331423	455/1359 (33%)
ABCC3	NP_003777.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	910..932		2/21 (10%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151511
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.660