DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and NFT1

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_013029.3	Gene:	NFT1 / 853978	SGDID:	S000001811	Length:	1218	Species:	Saccharomyces cerevisiae

Alignment Length:	1045	Identity:	269/1045 - (25%)
Similarity:	471/1045 - (45%)	Gaps:	166/1045 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KKLQTNPRESAGIFSTLMFCFALPILFKGRKKTLEPTDLYNALKEHKAETLGDKFFATWQSEVRS 68
            |||...|.    :|..|.|.....:::|..|..|...|:::....:|:..:...|      |:
Yeast   240 KKLPPAPT----VFGLLTFSRIDRLIWKAYKHCLGNADIWDLDINNKSIAILANF------EM-- 292

  Fly    69 CGDSPKKE---PSIIRVILKVFGWQLFLSGIVVGVLELGTRATLPLILGALIAEFTRNGNGDGLW 130
               |.||.   |:||.....||..||||: .|...|.......:|.||..:....:::.|    .
Yeast   293 ---SSKKGRLLPNIICYFKAVFISQLFLA-FVSSFLNFVPSLLMPRILSYVNDPKSKSWN----L 349

  Fly   131 AQIYGLTLILS-ILFSVLMFHPLMMGLMHLAMKMRVAVSTAIYRKALRLSRTALGDTTT------ 188
            ..:|..::::| |:.:......|.:|... .|::|..:.:.||.|.||  ||.|.|:||
Yeast   350 VSLYVSSMLVSKIIATTCRGQGLFLGEKG-TMQLRTVLISNIYSKTLR--RTILKDSTTSLQKNA 411

  Fly   189 -----------------------GQVVNLISNDLGRFDRALIHFHFLWLGPLELLISSYFLYQQI 230
                                   ..|.|::|.|..:...|:..|:.........:.:...||..:
Yeast   412 STSFEENPDSSEAEPRKKSSRKDNSVNNVMSIDAFKVSEAMNTFYLACEAVFMTVTALMILYSLL 476

  Fly   231 GVASLYGIVILLLFLPIQTFLSRLTSRLRHQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRL 295
            |.::..|...||..:|:..:.:......:....:.||:|...::|.::.|:|||:..||..|.:.
Yeast   477 GWSAFAGTFALLAMIPLNFWCATFYGNYQADQLILTDKRTSGISEALNSIRVIKLLAWENLFYQK 541

  Fly   296 IERLRRSEMSSIRK---VNYIRGTLLSFEITLSRIAIFVSLLGFVLMGGELTAERAFSVTAFYNI 357
            |..:|..|:..::|   :.::...:..|..||.....|...:.|  ....||...||:..:.:.|
Yeast   542 IINVRDGEIRLLKKKATIFFLNHLIWFFGPTLVSAITFSVFIKF--QNQTLTPTIAFTALSLFAI 604

  Fly   358 LRRTVCKFFPSGMSQFAEMMVTLRRIKGFMMRSETEAL-YLKGGQTNKLFEGEPLVKLQSFQARW 421
            | ||......|.:|...:..::|.||:.::..|||... .|:...|...||...:        .|
Yeast   605 L-RTPMDQIASTVSLLIQSFISLERIQDYLNESETRKYEILEQSNTKFGFEDASM--------EW 660

  Fly   422 NHDHVEPVLENINISLSPPQLVAVIGPVGSGKSSLIQAILGELPGESGKLKV------------- 473
            ........|:||:|......|.|:|||.|||||||:..:||||...|||:.|
Yeast   661 EAAETSFKLKNISIDFKLNSLNAIIGPTGSGKSSLLLGLLGELNLLSGKIYVPTVESRDDLEIGK 725

  Fly   474 ---QGDISYASQEPWLFNASVRDNILFGLPMDKHRYRNVIRNCALERDFE-LLHGDRTFVGERGA 534
               ...::|.||.|||.:.:::||::||...:|.::.:|:::|.|::|.: :..|.||.||:.|.
Yeast   726 DGMTNSMAYCSQTPWLISGTIKDNVVFGEIFNKQKFDDVMKSCCLDKDIKAMTAGIRTDVGDGGF 790

  Fly   535 SLSGGQRARISLARAVYRQADTYLLDDPLSAVDTHVGRHLFEECMRG-FLRDKLVILVTHQLQFL 598
            ||||||:.||:||||:|..:...:|||.|||||.....:::|||:.| .::.:..|:.:|.:..:
Yeast   791 SLSGGQQQRIALARAIYSSSRYLILDDCLSAVDPETALYIYEECLCGPMMKGRTCIITSHNISLV 855

  Fly   599 -EHADLIVIMDKGKISAVGTYEEMLKSGQDFGKLLATEAQEMGDSNQEQVNAEGDSRN------- 655
             :.||.:||:|:|::.:.|...:::||.:..               :|.:|  .||:|
Yeast   856 TKRADWLVILDRGEVKSQGKPSDLIKSNEFL---------------RESIN--NDSKNTTHNQID 903

  Fly   656 -DKSTYSRQSSRVSRVSVTSVDSSTESILDNERQPAQESRSQGKIGLGIY---GKYFSAGSGWLM 716
             .:||.|:::.........|.|.....:     :..:|::.:|.:....|   ..|| .|.|
Yeast   904 LKRSTTSKKTKNGDPEGGNSQDEVCAEV-----ENFEETKMEGSVKFSAYKWLADYF-GGLG--- 959

  Fly   717 VILVAFFCLGTQILASG----GDYFLSYWVKNNDS-SSSTDIY-IFSGIN-----AALVIFALLR 770
               |.|....:.||..|    ..::|.||:....| |.||.:| |..|.:     ...:|..|:.
Yeast   960 ---VVFVFTSSSILIHGITLSQGFWLRYWLDTGSSGSKSTWLYRIVEGHSNIYFLLTYIIIGLVS 1021

  Fly   771 TLLFFS---MAMHSSTQLHNTMFQGVSRTALY----FFHANPSGRILNRFAMDLGQVD-EILP-- 825
            :.|...   :|:.|.|.:...:|..:..:.||    |.:..|:|||:|||:.|:..:| :::|
Yeast  1022 SFLTSGKVWIAIISGTNVTKKIFAKLLSSILYAKLRFHNVTPTGRIMNRFSKDMDIIDQQLIPNF 1086

  Fly   826 -----AVMLDCIQIFLTISGIIGVLCITNPWYLINTITMFLAFHFLRTFYLSTSRDLKRLEAIAR 885
                 :|:: |:.|.|.|..:       .|.:|:..|.:...::.:.|.||..||:|||::.|..
Yeast  1087 EGLSYSVVV-CLWIILLIGYV-------TPQFLLFAIPLCALYYTVCTLYLRASRELKRIDNINI 1143

  Fly   886 SPMYSHFSATLNGLSTIRAM-EAQDLLTKEYDNYQDIHSSGYYTFLSTNRAFGYYLDLFCVAYVI 949
            ||::..|:..:.|::||||: :.:..:|:........::..:|..::| ....|.:|:.....:.
Yeast  1144 SPIHQLFAEAIKGVTTIRALADERRFITQSLVAIDRSNAPFFYLNMAT-EWITYRVDIIGTLVLF 1207

  Fly   950 SVTLM 954
            |.::|
Yeast  1208 SSSVM 1212

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	267/1043 (26%)
		ABC_membrane	92..362	CDD:294371	66/302 (22%)
		ABCC_MRP_domain1	412..611	CDD:213217	78/217 (36%)
		ABC_membrane	718..981	CDD:294371	67/264 (25%)
		ABCC_MRP_domain2	1029..1250	CDD:213211
NFT1	NP_013029.3	MRP_assoc_pro	252..>1218	CDD:188098	264/1029 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344653
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.830